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A8H7C2

- SYL_SHEPA

UniProt

A8H7C2 - SYL_SHEPA

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Shewanella pealeana (strain ATCC 700345 / ANG-SQ1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 2 (20 May 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei621 – 6211ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSPEA398579:GHG5-3301-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Spea_3143
    OrganismiShewanella pealeana (strain ATCC 700345 / ANG-SQ1)
    Taxonomic identifieri398579 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000002608: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 859859Leucine--tRNA ligasePRO_0000334819Add
    BLAST

    Proteomic databases

    PRIDEiA8H7C2.

    Interactioni

    Protein-protein interaction databases

    STRINGi398579.Spea_3143.

    Structurei

    3D structure databases

    ProteinModelPortaliA8H7C2.
    SMRiA8H7C2. Positions 228-412.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi618 – 6225"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8H7C2-1 [UniParc]FASTAAdd to Basket

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    MQEQYTPSEI EAKVQQHWQD TKTFEVTEDE NKEKFYCLSM FPYPSGRLHM    50
    GHVRNYTIGD VVSRYQRLQG KNVLQPIGWD SFGLPAENAA IKNNTAPAPW 100
    TYENIDYMKN QLKMLGFGYD WSREIATCTP EYYRWEQWFF TKLYEKGLVY 150
    KKTSSVNWCP NDETVLANEQ VIDGCCWRCD TTVEQKEIPQ WFIKITEYAE 200
    ELLNDIDTLE EWPEQVKTMQ RNWIGRSEGI EMTFQVAGSD QSFDIYTTRP 250
    DTVMGVTYVA IAAGHPLAEQ AAINNPALVE FIEECKNADT TEAAMAAMEK 300
    KGVATGLNAI HPITGKEVPI WVGNFVLMNY GTGAVMSVPA HDQRDYEFAK 350
    KYGLNIEAVI KPVDGEVDIS EEAYTEKGVL FNSAEFDGLD FQAAFDAIDA 400
    KLTAEGKGKR QVNFRLRDWG VSRQRYWGAP IPMVTLADGT VMPTPEDQLP 450
    VILPEDVVMD GIQSPIKSDK EWAKTTINGQ EAFRETDTFD TFMESSWYYA 500
    RYCSPHADEM LDPAKANYWL PVDQYIGGIE HACMHLLYFR FFHKLLRDTG 550
    LVNSNEPAKR LLTQGMVLAD AYYYNNEKGA RVWVAPSDVT VQETDDKGRT 600
    VKAVDSEGHE LVYTGMSKMS KSKNNGIDPQ EMVDKYGADT VRLFMMFAAP 650
    PELTLEWQES SVEGAHRFIK RLWKTAHDHI ANGTTAELDV KSLNAAQKEL 700
    RRELHKTIAK VGDDIERRQM FNTAIASIME LMNRLQKAPS ETDQDKALMQ 750
    EALNAVIRLL YPIIPHTCFV LWNELGNQGA IEEVLWPEVD ESALVEDSKL 800
    IIVQVNGKLR AKITVAADAS KEEVEAAGMA EEGVVKHTED KTVRKVIYVP 850
    GKLLNIVAN 859
    Length:859
    Mass (Da):97,391
    Last modified:May 20, 2008 - v2
    Checksum:iBE2D4C6317A1466E
    GO

    Sequence cautioni

    The sequence ABV88459.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000851 Genomic DNA. Translation: ABV88459.1. Different initiation.
    RefSeqiYP_001502994.1. NC_009901.1.

    Genome annotation databases

    EnsemblBacteriaiABV88459; ABV88459; Spea_3143.
    GeneIDi5663532.
    KEGGispl:Spea_3143.
    PATRICi23536403. VBIShePea72822_3286.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000851 Genomic DNA. Translation: ABV88459.1 . Different initiation.
    RefSeqi YP_001502994.1. NC_009901.1.

    3D structure databases

    ProteinModelPortali A8H7C2.
    SMRi A8H7C2. Positions 228-412.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 398579.Spea_3143.

    Proteomic databases

    PRIDEi A8H7C2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV88459 ; ABV88459 ; Spea_3143 .
    GeneIDi 5663532.
    KEGGi spl:Spea_3143.
    PATRICi 23536403. VBIShePea72822_3286.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci SPEA398579:GHG5-3301-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700345 / ANG-SQ1.

    Entry informationi

    Entry nameiSYL_SHEPA
    AccessioniPrimary (citable) accession number: A8H7C2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 49 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3