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A8H6K3

- LPXB_SHEPA

UniProt

A8H6K3 - LPXB_SHEPA

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Shewanella pealeana (strain ATCC 700345 / ANG-SQ1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciSPEA398579:GHG5-3015-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:Spea_2872
    OrganismiShewanella pealeana (strain ATCC 700345 / ANG-SQ1)
    Taxonomic identifieri398579 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000002608: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 383383Lipid-A-disaccharide synthasePRO_1000080285Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi398579.Spea_2872.

    Structurei

    3D structure databases

    ProteinModelPortaliA8H6K3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018003.
    KOiK00748.
    OMAiVSPITYR.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A8H6K3-1 [UniParc]FASTAAdd to Basket

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    MSSNNPRVFA MVAGEISGDI LGAGLIKALQ KQYPDAKFVG IGGPRMEALG    50
    FESIFSYEEL AVMGIVEVLS RLPRLLKVRA TLIDELVKTQ PDCFIGIDAP 100
    DFNIGLELKL KNRGIKTVHY VSPSVWAWRP KRIFKIAKAT DMVLSLLPFE 150
    KAFYDEYQVP CTFVGHTLAD DIELESDKAQ ARELLGLDKE AEYLAILPGS 200
    RGGELKMLAE PFVKAASLIK LRYPDIKFVT PLVNQKRRDQ FEQALREHAP 250
    DLEIHLIEGH SREVMAAADC ILLASGTATL EAMLVKRPMV VAYRVSPITY 300
    RIAKGMMLTK RYSLPNLLAD DDVVEELIQA DCTPEKIAAA VATQLDNDFT 350
    PMYDRFMQMH KGLRCDASAR AADAVIKLVE DNV 383
    Length:383
    Mass (Da):42,615
    Last modified:November 13, 2007 - v1
    Checksum:i9FB4E8D3CC1C0FAC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000851 Genomic DNA. Translation: ABV88190.1.
    RefSeqiYP_001502725.1. NC_009901.1.

    Genome annotation databases

    EnsemblBacteriaiABV88190; ABV88190; Spea_2872.
    GeneIDi5663263.
    KEGGispl:Spea_2872.
    PATRICi23535815. VBIShePea72822_3007.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000851 Genomic DNA. Translation: ABV88190.1 .
    RefSeqi YP_001502725.1. NC_009901.1.

    3D structure databases

    ProteinModelPortali A8H6K3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 398579.Spea_2872.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV88190 ; ABV88190 ; Spea_2872 .
    GeneIDi 5663263.
    KEGGi spl:Spea_2872.
    PATRICi 23535815. VBIShePea72822_3007.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018003.
    KOi K00748.
    OMAi VSPITYR.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci SPEA398579:GHG5-3015-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700345 / ANG-SQ1.

    Entry informationi

    Entry nameiLPXB_SHEPA
    AccessioniPrimary (citable) accession number: A8H6K3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3