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A8H6K3

- LPXB_SHEPA

UniProt

A8H6K3 - LPXB_SHEPA

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Protein

Lipid-A-disaccharide synthase

Gene
lpxB, Spea_2872
Organism
Shewanella pealeana (strain ATCC 700345 / ANG-SQ1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciSPEA398579:GHG5-3015-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:Spea_2872
OrganismiShewanella pealeana (strain ATCC 700345 / ANG-SQ1)
Taxonomic identifieri398579 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000002608: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 383383Lipid-A-disaccharide synthaseUniRule annotationPRO_1000080285Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi398579.Spea_2872.

Structurei

3D structure databases

ProteinModelPortaliA8H6K3.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

A8H6K3-1 [UniParc]FASTAAdd to Basket

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MSSNNPRVFA MVAGEISGDI LGAGLIKALQ KQYPDAKFVG IGGPRMEALG    50
FESIFSYEEL AVMGIVEVLS RLPRLLKVRA TLIDELVKTQ PDCFIGIDAP 100
DFNIGLELKL KNRGIKTVHY VSPSVWAWRP KRIFKIAKAT DMVLSLLPFE 150
KAFYDEYQVP CTFVGHTLAD DIELESDKAQ ARELLGLDKE AEYLAILPGS 200
RGGELKMLAE PFVKAASLIK LRYPDIKFVT PLVNQKRRDQ FEQALREHAP 250
DLEIHLIEGH SREVMAAADC ILLASGTATL EAMLVKRPMV VAYRVSPITY 300
RIAKGMMLTK RYSLPNLLAD DDVVEELIQA DCTPEKIAAA VATQLDNDFT 350
PMYDRFMQMH KGLRCDASAR AADAVIKLVE DNV 383
Length:383
Mass (Da):42,615
Last modified:November 13, 2007 - v1
Checksum:i9FB4E8D3CC1C0FAC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000851 Genomic DNA. Translation: ABV88190.1.
RefSeqiYP_001502725.1. NC_009901.1.

Genome annotation databases

EnsemblBacteriaiABV88190; ABV88190; Spea_2872.
GeneIDi5663263.
KEGGispl:Spea_2872.
PATRICi23535815. VBIShePea72822_3007.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000851 Genomic DNA. Translation: ABV88190.1 .
RefSeqi YP_001502725.1. NC_009901.1.

3D structure databases

ProteinModelPortali A8H6K3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 398579.Spea_2872.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV88190 ; ABV88190 ; Spea_2872 .
GeneIDi 5663263.
KEGGi spl:Spea_2872.
PATRICi 23535815. VBIShePea72822_3007.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci SPEA398579:GHG5-3015-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700345 / ANG-SQ1.

Entry informationi

Entry nameiLPXB_SHEPA
AccessioniPrimary (citable) accession number: A8H6K3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 13, 2007
Last modified: May 14, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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