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A8H5H1 (CDD_SHEPA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cytidine deaminase
EC=3.5.4.5
Alternative name(s):
Cytidine aminohydrolase
Short name=CDA
Gene names
Name:cdd
Ordered Locus Names:Spea_2488
OrganismShewanella pealeana (strain ATCC 700345 / ANG-SQ1) [Complete proteome] [HAMAP]
Taxonomic identifier398579 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length296 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis By similarity. HAMAP MF_01558

Catalytic activity

Cytidine + H2O = uridine + NH3. HAMAP MF_01558

Cofactor

Binds 1 zinc ion By similarity. HAMAP MF_01558

Subunit structure

Homodimer By similarity. HAMAP MF_01558

Sequence similarities

Belongs to the cytidine and deoxycytidylate deaminase family.

Ontologies

Keywords
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functioncytidine deaminase activity

Inferred from electronic annotation. Source: EC

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 296296Cytidine deaminase HAMAP MF_01558
PRO_1000087799

Regions

Region88 – 903Substrate binding By similarity

Sites

Active site1031Proton donor By similarity
Metal binding1011Zinc; catalytic By similarity
Metal binding1281Zinc; catalytic By similarity
Metal binding1311Zinc; catalytic By similarity

Sequences

Sequence LengthMass (Da)Tools
A8H5H1 [UniParc].

Last modified November 13, 2007. Version 1.
Checksum: 182E1404EEA9C6C1

FASTA29631,840
        10         20         30         40         50         60 
MQDRFLKSIA KLPEPLATAI VPLLDKDFAG HIDAQQLAEL QAASKMELNE LLLALLPIAA 

        70         80         90        100        110        120 
ALARPPISQF HVGAIAKGKS GDIYMGANIE LPGEALFHSV HAEQSAISHA WLSGESIIED 

       130        140        150        160        170        180 
IIVNASPCGH CRQFINELVD GGKVNIHLPD QATAPLSHYL PYAFGPSDLD VTEPLLSKQQ 

       190        200        210        220        230        240 
QTLTLDSNDP MIIEGLDHAG LSYAPYTKAY ASVVLETKDG ATYCGRYAEN AAFNPSMQPM 

       250        260        270        280        290 
QMALSTMARH NRDFSEINRA VLIESSKGVI SLVGAAMDAL HSVAAVELEH IVVEPE

« Hide

References

[1]"Complete sequence of Shewanella pealeana ATCC 700345."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Kim E., Zhao J.-S.Z., Manno D., Hawari J., Richardson P.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700345 / ANG-SQ1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000851 Genomic DNA. Translation: ABV87808.1.
RefSeqYP_001502343.1. NC_009901.1.

3D structure databases

ProteinModelPortalA8H5H1.
ModBaseSearch...

Protein-protein interaction databases

STRINGA8H5H1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5662881.
GenomeReviewsGene locus Spea_2488 in contig CP000851_GR.
KEGGspl:Spea_2488.
NMPDRfig|398579.3.peg.2146.
PATRIC23534981. VBIShePea72822_2605.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0295.
HOGENOMHBG591160.
OMANRSHAPY.
ProtClustDBPRK09027.

Enzyme and pathway databases

BioCycSPEA398579:SPEA_2488-MONOMER.

Family and domain databases

HAMAPMF_01558. Cyt_deam.
[Tree]
InterProIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR013171. Cyd/dCyd_deaminase_Zn-bd.
IPR006263. Cyt_deam_dimer.
IPR016193. Cytidine_deaminase-like.
IPR020797. Cytidine_deaminase_bacteria.
[Graphical view]
KOK01489.
PANTHERPTHR11644:SF12. PTHR11644:SF12. 1 hit.
PfamPF00383. dCMP_cyt_deam_1. 1 hit.
PF08211. dCMP_cyt_deam_2. 1 hit.
[Graphical view]
PIRSFPIRSF006334. Cdd_plus_pseudo. 1 hit.
SUPFAMSSF53927. Cytidine_deaminase-like. 2 hits.
PROSITEPS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCDD_SHEPA
AccessionPrimary (citable) accession number: A8H5H1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 13, 2007
Last modified: January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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