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A8H5H1

- CDD_SHEPA

UniProt

A8H5H1 - CDD_SHEPA

Protein

Cytidine deaminase

Gene

cdd

Organism
Shewanella pealeana (strain ATCC 700345 / ANG-SQ1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.UniRule annotation

    Catalytic activityi

    Cytidine + H2O = uridine + NH3.UniRule annotation
    2'deoxycytidine + H2O = 2'-deoxyuridine + NH3.UniRule annotation

    Cofactori

    Binds 1 zinc ion.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi101 – 1011Zinc; catalyticUniRule annotation
    Active sitei103 – 1031Proton donorUniRule annotation
    Metal bindingi128 – 1281Zinc; catalyticUniRule annotation
    Metal bindingi131 – 1311Zinc; catalyticUniRule annotation

    GO - Molecular functioni

    1. cytidine deaminase activity Source: UniProtKB-HAMAP
    2. zinc ion binding Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciSPEA398579:GHG5-2615-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytidine deaminaseUniRule annotation (EC:3.5.4.5UniRule annotation)
    Alternative name(s):
    Cytidine aminohydrolaseUniRule annotation
    Short name:
    CDAUniRule annotation
    Gene namesi
    Name:cddUniRule annotation
    Ordered Locus Names:Spea_2488
    OrganismiShewanella pealeana (strain ATCC 700345 / ANG-SQ1)
    Taxonomic identifieri398579 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000002608: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 296296Cytidine deaminasePRO_1000087799Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi398579.Spea_2488.

    Structurei

    3D structure databases

    ProteinModelPortaliA8H5H1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini50 – 13889CMP/dCMP deaminase zinc-bindingAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni88 – 903Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the cytidine and deoxycytidylate deaminase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0295.
    HOGENOMiHOG000218617.
    KOiK01489.
    OMAiNRSHAPY.
    OrthoDBiEOG6XDH25.

    Family and domain databases

    HAMAPiMF_01558. Cyt_deam.
    InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
    IPR002125. CMP_dCMP_Zn-bd.
    IPR013171. Cyd/dCyd_deaminase_Zn-bd.
    IPR006263. Cyt_deam_dimer.
    IPR016193. Cytidine_deaminase-like.
    IPR020797. Cytidine_deaminase_bacteria.
    [Graphical view]
    PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
    PF08211. dCMP_cyt_deam_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006334. Cdd_plus_pseudo. 1 hit.
    SUPFAMiSSF53927. SSF53927. 2 hits.
    PROSITEiPS00903. CYT_DCMP_DEAMINASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8H5H1-1 [UniParc]FASTAAdd to Basket

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    MQDRFLKSIA KLPEPLATAI VPLLDKDFAG HIDAQQLAEL QAASKMELNE    50
    LLLALLPIAA ALARPPISQF HVGAIAKGKS GDIYMGANIE LPGEALFHSV 100
    HAEQSAISHA WLSGESIIED IIVNASPCGH CRQFINELVD GGKVNIHLPD 150
    QATAPLSHYL PYAFGPSDLD VTEPLLSKQQ QTLTLDSNDP MIIEGLDHAG 200
    LSYAPYTKAY ASVVLETKDG ATYCGRYAEN AAFNPSMQPM QMALSTMARH 250
    NRDFSEINRA VLIESSKGVI SLVGAAMDAL HSVAAVELEH IVVEPE 296
    Length:296
    Mass (Da):31,840
    Last modified:November 13, 2007 - v1
    Checksum:i182E1404EEA9C6C1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000851 Genomic DNA. Translation: ABV87808.1.
    RefSeqiWP_012155717.1. NC_009901.1.
    YP_001502343.1. NC_009901.1.

    Genome annotation databases

    EnsemblBacteriaiABV87808; ABV87808; Spea_2488.
    GeneIDi5662881.
    KEGGispl:Spea_2488.
    PATRICi23534981. VBIShePea72822_2605.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000851 Genomic DNA. Translation: ABV87808.1 .
    RefSeqi WP_012155717.1. NC_009901.1.
    YP_001502343.1. NC_009901.1.

    3D structure databases

    ProteinModelPortali A8H5H1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 398579.Spea_2488.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV87808 ; ABV87808 ; Spea_2488 .
    GeneIDi 5662881.
    KEGGi spl:Spea_2488.
    PATRICi 23534981. VBIShePea72822_2605.

    Phylogenomic databases

    eggNOGi COG0295.
    HOGENOMi HOG000218617.
    KOi K01489.
    OMAi NRSHAPY.
    OrthoDBi EOG6XDH25.

    Enzyme and pathway databases

    BioCyci SPEA398579:GHG5-2615-MONOMER.

    Family and domain databases

    HAMAPi MF_01558. Cyt_deam.
    InterProi IPR016192. APOBEC/CMP_deaminase_Zn-bd.
    IPR002125. CMP_dCMP_Zn-bd.
    IPR013171. Cyd/dCyd_deaminase_Zn-bd.
    IPR006263. Cyt_deam_dimer.
    IPR016193. Cytidine_deaminase-like.
    IPR020797. Cytidine_deaminase_bacteria.
    [Graphical view ]
    Pfami PF00383. dCMP_cyt_deam_1. 1 hit.
    PF08211. dCMP_cyt_deam_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006334. Cdd_plus_pseudo. 1 hit.
    SUPFAMi SSF53927. SSF53927. 2 hits.
    PROSITEi PS00903. CYT_DCMP_DEAMINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700345 / ANG-SQ1.

    Entry informationi

    Entry nameiCDD_SHEPA
    AccessioniPrimary (citable) accession number: A8H5H1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3