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A8H5G3

- SPEA_SHEPA

UniProt

A8H5G3 - SPEA_SHEPA

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Protein
Biosynthetic arginine decarboxylase
Gene
speA, Spea_2480
Organism
Shewanella pealeana (strain ATCC 700345 / ANG-SQ1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the biosynthesis of agmatine from arginine By similarity.UniRule annotation

Catalytic activityi

L-arginine = agmatine + CO2.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation
Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. arginine decarboxylase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. arginine catabolic process Source: InterPro
  2. spermidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Polyamine biosynthesis, Spermidine biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding, Pyridoxal phosphate

Enzyme and pathway databases

BioCyciSPEA398579:GHG5-2607-MONOMER.
UniPathwayiUPA00186; UER00284.

Names & Taxonomyi

Protein namesi
Recommended name:
Biosynthetic arginine decarboxylase (EC:4.1.1.19)
Short name:
ADC
Gene namesi
Name:speA
Ordered Locus Names:Spea_2480
OrganismiShewanella pealeana (strain ATCC 700345 / ANG-SQ1)
Taxonomic identifieri398579 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000002608: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 637637Biosynthetic arginine decarboxylaseUniRule annotation
PRO_1000087408Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei101 – 1011N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Protein-protein interaction databases

STRINGi398579.Spea_2480.

Structurei

3D structure databases

ProteinModelPortaliA8H5G3.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni286 – 29611Substrate-binding Reviewed prediction
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1166.
HOGENOMiHOG000029191.
KOiK01585.
OMAiIDHYVDG.
OrthoDBiEOG676Z0R.

Family and domain databases

Gene3Di2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPiMF_01417. SpeA.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022644. De-COase2_N.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSiPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01273. speA. 1 hit.

Sequencei

Sequence statusi: Complete.

A8H5G3-1 [UniParc]FASTAAdd to Basket

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MSNWSIDDAR ASYNVNHWSQ GLYGISDDGE VTVSPDPSRP DCKIGLNEMA    50
KDMVKSGVAL PVLVRFPQIL HHRVNSVCQA FNQAINKYQY ENDYLLVYPI 100
KVNQQQTVVE EILASQVAKE VPQLGLEAGS KPELMAVLAM AQKASSVIIC 150
NGYKDKEYIR LALIGEKLGH KVYIVLEKMS ELKVVLEQAK ELGVTPRLGL 200
RVRLAFQGKG KWQASGGEKS KFGLSAAQVL QVINSLKQEN MLESLELLHF 250
HLGSQIANIR DIRQGVSEAG RFYCELMKLG ASVKCFDVGG GLAVDYDGTR 300
SQSSHSMNYG LTEYANNIVS VLTDMCKEYE QPMPRIISES GRYLTAHHAV 350
LLTDVIGTEA YKPEDIQPPA EDAPQLLHNM WQSWIEVSGK ADQRALIEIY 400
HDCQSDLTEV HSLFAVGQLG LAERAWAEQV NLRVCYELQG SMSAKYRFHR 450
PVIDELNEKL ADKFFVNFSL FQSLPDAWGI DQVFPVMPLS GLDKAPESRA 500
VMLDITCDSD GTVDQYVEGQ GIETTLPVPA WTQESPYLIG FFLVGAYQEI 550
LGDMHNLFGD TNSAVVRLDD DARTNVESVL AGDTVADVLR YVNLDAVSFM 600
RTYEELVNKH IAEDERANIL EELQLGLKGY TYLEDFS 637
Length:637
Mass (Da):71,054
Last modified:November 13, 2007 - v1
Checksum:i0A8031C33DEF8B37
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000851 Genomic DNA. Translation: ABV87800.1.
RefSeqiWP_012155709.1. NC_009901.1.
YP_001502335.1. NC_009901.1.

Genome annotation databases

EnsemblBacteriaiABV87800; ABV87800; Spea_2480.
GeneIDi5662873.
KEGGispl:Spea_2480.
PATRICi23534963. VBIShePea72822_2596.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000851 Genomic DNA. Translation: ABV87800.1 .
RefSeqi WP_012155709.1. NC_009901.1.
YP_001502335.1. NC_009901.1.

3D structure databases

ProteinModelPortali A8H5G3.
ModBasei Search...

Protein-protein interaction databases

STRINGi 398579.Spea_2480.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV87800 ; ABV87800 ; Spea_2480 .
GeneIDi 5662873.
KEGGi spl:Spea_2480.
PATRICi 23534963. VBIShePea72822_2596.

Phylogenomic databases

eggNOGi COG1166.
HOGENOMi HOG000029191.
KOi K01585.
OMAi IDHYVDG.
OrthoDBi EOG676Z0R.

Enzyme and pathway databases

UniPathwayi UPA00186 ; UER00284 .
BioCyci SPEA398579:GHG5-2607-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPi MF_01417. SpeA.
InterProi IPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022644. De-COase2_N.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view ]
PIRSFi PIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSi PR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMi SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR01273. speA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700345 / ANG-SQ1.

Entry informationi

Entry nameiSPEA_SHEPA
AccessioniPrimary (citable) accession number: A8H5G3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 13, 2007
Last modified: September 3, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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