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A8H5G3 (SPEA_SHEPA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Biosynthetic arginine decarboxylase

Short name=ADC
EC=4.1.1.19
Gene names
Name:speA
Ordered Locus Names:Spea_2480
OrganismShewanella pealeana (strain ATCC 700345 / ANG-SQ1) [Complete proteome] [HAMAP]
Taxonomic identifier398579 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Protein attributes

Sequence length637 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the biosynthesis of agmatine from arginine By similarity. HAMAP-Rule MF_01417

Catalytic activity

L-arginine = agmatine + CO2. HAMAP-Rule MF_01417

Cofactor

Magnesium By similarity. HAMAP-Rule MF_01417

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01417

Pathway

Amine and polyamine biosynthesis; agmatine biosynthesis; agmatine from L-arginine: step 1/1. HAMAP-Rule MF_01417

Sequence similarities

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 637637Biosynthetic arginine decarboxylase HAMAP-Rule MF_01417
PRO_1000087408

Regions

Region286 – 29611Substrate-binding Potential

Amino acid modifications

Modified residue1011N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
A8H5G3 [UniParc].

Last modified November 13, 2007. Version 1.
Checksum: 0A8031C33DEF8B37

FASTA63771,054
        10         20         30         40         50         60 
MSNWSIDDAR ASYNVNHWSQ GLYGISDDGE VTVSPDPSRP DCKIGLNEMA KDMVKSGVAL 

        70         80         90        100        110        120 
PVLVRFPQIL HHRVNSVCQA FNQAINKYQY ENDYLLVYPI KVNQQQTVVE EILASQVAKE 

       130        140        150        160        170        180 
VPQLGLEAGS KPELMAVLAM AQKASSVIIC NGYKDKEYIR LALIGEKLGH KVYIVLEKMS 

       190        200        210        220        230        240 
ELKVVLEQAK ELGVTPRLGL RVRLAFQGKG KWQASGGEKS KFGLSAAQVL QVINSLKQEN 

       250        260        270        280        290        300 
MLESLELLHF HLGSQIANIR DIRQGVSEAG RFYCELMKLG ASVKCFDVGG GLAVDYDGTR 

       310        320        330        340        350        360 
SQSSHSMNYG LTEYANNIVS VLTDMCKEYE QPMPRIISES GRYLTAHHAV LLTDVIGTEA 

       370        380        390        400        410        420 
YKPEDIQPPA EDAPQLLHNM WQSWIEVSGK ADQRALIEIY HDCQSDLTEV HSLFAVGQLG 

       430        440        450        460        470        480 
LAERAWAEQV NLRVCYELQG SMSAKYRFHR PVIDELNEKL ADKFFVNFSL FQSLPDAWGI 

       490        500        510        520        530        540 
DQVFPVMPLS GLDKAPESRA VMLDITCDSD GTVDQYVEGQ GIETTLPVPA WTQESPYLIG 

       550        560        570        580        590        600 
FFLVGAYQEI LGDMHNLFGD TNSAVVRLDD DARTNVESVL AGDTVADVLR YVNLDAVSFM 

       610        620        630 
RTYEELVNKH IAEDERANIL EELQLGLKGY TYLEDFS 

« Hide

References

[1]"Complete sequence of Shewanella pealeana ATCC 700345."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Kim E., Zhao J.-S.Z., Manno D., Hawari J., Richardson P.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700345 / ANG-SQ1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000851 Genomic DNA. Translation: ABV87800.1.
RefSeqYP_001502335.1. NC_009901.1.

3D structure databases

ProteinModelPortalA8H5G3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING398579.Spea_2480.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABV87800; ABV87800; Spea_2480.
GeneID5662873.
KEGGspl:Spea_2480.
PATRIC23534963. VBIShePea72822_2596.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1166.
HOGENOMHOG000029191.
KOK01585.
OMAMIHFHIG.
OrthoDBEOG676Z0R.
ProtClustDBPRK05354.

Enzyme and pathway databases

BioCycSPEA398579:GHG5-2607-MONOMER.
UniPathwayUPA00186; UER00284.

Family and domain databases

Gene3D2.40.37.10. 2 hits.
HAMAPMF_01417. SpeA.
InterProIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022644. De-COase2_N.
IPR000183. Orn/DAP/Arg_de-COase.
[Graphical view]
PfamPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
TIGRFAMsTIGR01273. speA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSPEA_SHEPA
AccessionPrimary (citable) accession number: A8H5G3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 13, 2007
Last modified: February 19, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways