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A8H5E7 (PUR7_SHEPA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
EC=6.3.2.6
Alternative name(s):
SAICAR synthetase
Gene names
Name:purC
Ordered Locus Names:Spea_2464
OrganismShewanella pealeana (strain ATCC 700345 / ANG-SQ1) [Complete proteome] [HAMAP]
Taxonomic identifier398579 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length367 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. HAMAP MF_00137

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. HAMAP MF_00137

Sequence similarities

Belongs to the SAICAR synthetase family.

Ontologies

Keywords
   Biological processPurine biosynthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpurine nucleotide biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoribosylaminoimidazolesuccinocarboxamide synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 367367Phosphoribosylaminoimidazole-succinocarboxamide synthase HAMAP MF_00137
PRO_1000117850

Sequences

Sequence LengthMass (Da)Tools
A8H5E7 [UniParc].

Last modified November 13, 2007. Version 1.
Checksum: 1A7FC139875BF024

FASTA36741,365
        10         20         30         40         50         60 
MNLADKVLVV NDNLPIRTDK PVHSGKVRSV YWLTEEDSAR LIKDKGYDVP ADAPLAIMVI 

        70         80         90        100        110        120 
SDRISAFDCV WQGENGLNGV PGKGTALNAI SNHWFKLFKD KGLADSHILD IPHPLVWIVQ 

       130        140        150        160        170        180 
KARPVMIEAI ARQYITGSMW RSYTKGEREF CGITIPEGLE KDQKLPELLI TPSTKGVLTG 

       190        200        210        220        230        240 
LEGVPEADDV NVSRSDIERH VKGFNFSNES DIDLYEKLLK EGFDVISDAL AEHDQIFVDT 

       250        260        270        280        290        300 
KFEFGYVNDA AGNEKLIYMD EVGTPDSSRI WDGSSHRDGK IIEQSKEGFR QWLLNHFPDP 

       310        320        330        340        350        360 
DILLNKNRMV ERFALASDNK LPESVMMDIS NTYVGIAEKI IGKKLHISDN PKQEIIDILR 


DEYQLIV

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References

[1]"Complete sequence of Shewanella pealeana ATCC 700345."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Kim E., Zhao J.-S.Z., Manno D., Hawari J., Richardson P.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700345 / ANG-SQ1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000851 Genomic DNA. Translation: ABV87784.1.
RefSeqYP_001502319.1. NC_009901.1.

3D structure databases

ProteinModelPortalA8H5E7.
ModBaseSearch...

Protein-protein interaction databases

STRINGA8H5E7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5662857.
GenomeReviewsGene locus Spea_2464 in contig CP000851_GR.
KEGGspl:Spea_2464.
NMPDRfig|398579.3.peg.2124.
PATRIC23534930. VBIShePea72822_2580.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0152.
HOGENOMHBG555040.
OMASSRIWDG.
ProtClustDBPRK13960.

Enzyme and pathway databases

BioCycSPEA398579:SPEA_2464-MONOMER.

Family and domain databases

HAMAPMF_00137. SAICAR_synth.
[Tree]
InterProIPR013816. ATP_grasp_subdomain_2.
IPR014106. PurC_vibrio.
IPR001636. SAICAR_synth.
[Graphical view]
Gene3DG3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
KOK01923.
PANTHERPTHR11609. SAICAR_synt. 1 hit.
PfamPF01259. SAICAR_synt. 1 hit.
[Graphical view]
TIGRFAMsTIGR02735. PurC_vibrio. 1 hit.
PROSITEPS01057. SAICAR_SYNTHETASE_1. False negative.
PS01058. SAICAR_SYNTHETASE_2. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePUR7_SHEPA
AccessionPrimary (citable) accession number: A8H5E7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 13, 2007
Last modified: January 25, 2012
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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