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A8H4F0

- ACDH_SHEPA

UniProt

A8H4F0 - ACDH_SHEPA

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Protein

Acetaldehyde dehydrogenase

Gene
Spea_2117
Organism
Shewanella pealeana (strain ATCC 700345 / ANG-SQ1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei130 – 1301Acyl-thioester intermediate By similarity
Binding sitei272 – 2721NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 154NAD By similarity
Nucleotide bindingi161 – 1699NAD By similarity

GO - Molecular functioni

  1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
  2. NAD binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciSPEA398579:GHG5-2221-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase (EC:1.2.1.10)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]
Gene namesi
Ordered Locus Names:Spea_2117
OrganismiShewanella pealeana (strain ATCC 700345 / ANG-SQ1)
Taxonomic identifieri398579 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000002608: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307Acetaldehyde dehydrogenaseUniRule annotationPRO_0000387740Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi398579.Spea_2117.

Structurei

3D structure databases

ProteinModelPortaliA8H4F0.
SMRiA8H4F0. Positions 1-293.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK04073.
OMAiVEPPMIM.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

A8H4F0-1 [UniParc]FASTAAdd to Basket

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MTSKIKCALI GSGNIGTDLL YKLLRSDVLE PVWMVGIDPD SDGLAKAKAA    50
GLKVTADGID GLLPFVEADE IKIAFDATSA YVHAENSRKL NELGVVMIDL 100
TPAAIGPFCV PPVNLEQLDE NINNINMVTC GGQATIPMVA AVSQVQAVEY 150
GEIVATVSSR SVGPGTRQNI DEFTRTTAGA VEQIGGAEKG KAIIVINPAE 200
PPLLMRDTIH CLTKDQPDEQ AITASVHKMI EQVQQYVPGY TLKNGPVFDG 250
RKVTIFLEVE GLGDYLPKYA GNLDIMTAAA ARTAEMLASK MLNVKTHLNV 300
TKEAALA 307
Length:307
Mass (Da):32,661
Last modified:November 13, 2007 - v1
Checksum:iB33309C1B7897236
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000851 Genomic DNA. Translation: ABV87437.1.
RefSeqiWP_012155353.1. NC_009901.1.
YP_001501972.1. NC_009901.1.

Genome annotation databases

EnsemblBacteriaiABV87437; ABV87437; Spea_2117.
GeneIDi5662510.
KEGGispl:Spea_2117.
PATRICi23534146. VBIShePea72822_2211.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000851 Genomic DNA. Translation: ABV87437.1 .
RefSeqi WP_012155353.1. NC_009901.1.
YP_001501972.1. NC_009901.1.

3D structure databases

ProteinModelPortali A8H4F0.
SMRi A8H4F0. Positions 1-293.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 398579.Spea_2117.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV87437 ; ABV87437 ; Spea_2117 .
GeneIDi 5662510.
KEGGi spl:Spea_2117.
PATRICi 23534146. VBIShePea72822_2211.

Phylogenomic databases

eggNOGi COG4569.
HOGENOMi HOG000052149.
KOi K04073.
OMAi VEPPMIM.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci SPEA398579:GHG5-2221-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700345 / ANG-SQ1.

Entry informationi

Entry nameiACDH_SHEPA
AccessioniPrimary (citable) accession number: A8H4F0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: November 13, 2007
Last modified: September 3, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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