ID   A8H2Q3_SHEPA            Unreviewed;       949 AA.
AC   A8H2Q3;
DT   13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2007, sequence version 1.
DT   24-JAN-2024, entry version 78.
DE   RecName: Full=exo-alpha-sialidase {ECO:0000256|ARBA:ARBA00012733};
DE            EC=3.2.1.18 {ECO:0000256|ARBA:ARBA00012733};
GN   OrderedLocusNames=Spea_1515 {ECO:0000313|EMBL:ABV86840.1};
OS   Shewanella pealeana (strain ATCC 700345 / ANG-SQ1).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=398579 {ECO:0000313|EMBL:ABV86840.1, ECO:0000313|Proteomes:UP000002608};
RN   [1] {ECO:0000313|EMBL:ABV86840.1, ECO:0000313|Proteomes:UP000002608}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700345 / ANG-SQ1 {ECO:0000313|Proteomes:UP000002608};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Detter J.C.,
RA   Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E.,
RA   Zhao J.-S.Z., Manno D., Hawari J., Richardson P.;
RT   "Complete sequence of Shewanella pealeana ATCC 700345.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 33 family.
CC       {ECO:0000256|ARBA:ARBA00009348}.
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DR   EMBL; CP000851; ABV86840.1; -; Genomic_DNA.
DR   RefSeq; WP_012154764.1; NC_009901.1.
DR   AlphaFoldDB; A8H2Q3; -.
DR   STRING; 398579.Spea_1515; -.
DR   CAZy; CBM40; Carbohydrate-Binding Module Family 40.
DR   CAZy; GH33; Glycoside Hydrolase Family 33.
DR   KEGG; spl:Spea_1515; -.
DR   eggNOG; COG4409; Bacteria.
DR   HOGENOM; CLU_310115_0_0_6; -.
DR   OrthoDB; 7294637at2; -.
DR   Proteomes; UP000002608; Chromosome.
DR   GO; GO:0052794; F:exo-alpha-(2->3)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052795; F:exo-alpha-(2->6)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052796; F:exo-alpha-(2->8)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0033691; F:sialic acid binding; IEA:InterPro.
DR   GO; GO:0008152; P:metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   Gene3D; 2.60.120.200; -; 3.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   InterPro; IPR015344; VCNA_lectin-like_dom.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   Pfam; PF13385; Laminin_G_3; 1.
DR   Pfam; PF09264; Sial-lect-inser; 2.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 3.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000313|EMBL:ABV86840.1};
KW   Hydrolase {ECO:0000313|EMBL:ABV86840.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002608};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           27..949
FT                   /note="exo-alpha-sialidase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002722289"
FT   DOMAIN          59..217
FT                   /note="Vibrio cholerae neuraminidase lectin-like"
FT                   /evidence="ECO:0000259|Pfam:PF09264"
FT   DOMAIN          437..583
FT                   /note="Vibrio cholerae neuraminidase lectin-like"
FT                   /evidence="ECO:0000259|Pfam:PF09264"
FT   DOMAIN          639..925
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13088"
SQ   SEQUENCE   949 AA;  101903 MW;  A7120BF1161DB235 CRC64;
     MLRTITLTAL FITLCSMGFS SGYAQANTLV ANFDAMNETS PTIQGWSDFL SGQATGSVAQ
     DLNAASWKST GSSGRAQWNM VPTTELNNEA SLKGWRMSWT SRVESGGYIT DYYANGALRF
     LPILSISASG DLVVNLVGGG EHTLVSGTGA DSYHQYVVEY DPLTQLASFS FDGVIIDPAW
     VGEASNQNMI AWGNGSSNIN GVAYYRAVTF ETLSETVPEE AKIIAAWDSS GVTFDGESQF
     ISINTELASV QQLARGSIFT KFKATGTTAT LFSASNSAVG SSEFAILING DGTLRVHARE
     NGSFVNDSKT VTTFNNNQEH KALIMVDANG TQIYVDGRLA FSGNATSFLS AIAGLDSMNI
     GRNHDSNGGQ WYFSGTIDET RIYDNVLTAE QAEDLTRLST VVATFDSNLN TDPLLAGWTN
     DSVDSGAGSL VNEQGQAAWQ ARGINGRAEW EIQPSVQVNR DATTLGWKMT TTSRIVSGSA
     ISDYYANGNK RFLALLSING NGDLVAALEG GSSHTLVPMT GADKYHTYEV TYDVETSLAT
     FYFDGIAIET WAGSATSQNV IVWGNGSSGT NGVANYRYVN FETFGSGPAI FESIVFQGGQ
     EGDDGMSHYR IPSMVQSADG SILAFIEGRP SGGDPGQVGQ INISLKRSID NGRSWLPVQI
     IHQDPAFDYS DPRPFVDKST NTVYVFYVQW PDLCAQNGNC VAPDDANYLY YRKSIDNGLT
     WSAAVDVTSQ VKDPTWRSIN PGPGQGIQLQ WQTLAQGEHN GRMIFPAIVR AGNSLFYVAT
     VFSDDNGLTW HKGEFTPVSG PTEADMVELN DGTLLLSARN DGGAAGTRYH FLSHDGGITW
     TQTSHDLAVS KVDIGLTRFS AIRAGDAEDL IIATAPIGTT SGPNRNNLGI WVSTDEGANF
     GTPHQLVYGM SAYSDVVRLN DGSIGVIYEA TGSTLLKFLN FELSSLERQ
//