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A8H1B4

- TYSY_SHEPA

UniProt

A8H1B4 - TYSY_SHEPA

Protein

Thymidylate synthase

Gene

thyA

Organism
Shewanella pealeana (strain ATCC 700345 / ANG-SQ1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (13 Nov 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Provides the sole de novo source of dTMP for DNA biosynthesis.UniRule annotation

    Catalytic activityi

    5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei160 – 1601UniRule annotation

    GO - Molecular functioni

    1. thymidylate synthase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dTMP biosynthetic process Source: UniProtKB-HAMAP
    2. dTTP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Nucleotide biosynthesis

    Enzyme and pathway databases

    BioCyciSPEA398579:GHG5-1065-MONOMER.
    UniPathwayiUPA00575.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidylate synthaseUniRule annotation (EC:2.1.1.45UniRule annotation)
    Short name:
    TSUniRule annotation
    Short name:
    TSaseUniRule annotation
    Gene namesi
    Name:thyAUniRule annotation
    Ordered Locus Names:Spea_1024
    OrganismiShewanella pealeana (strain ATCC 700345 / ANG-SQ1)
    Taxonomic identifieri398579 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000002608: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 283283Thymidylate synthasePRO_1000073885Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi398579.Spea_1024.

    Structurei

    3D structure databases

    ProteinModelPortaliA8H1B4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0207.
    HOGENOMiHOG000257900.
    KOiK00560.
    OMAiDVHLYSN.
    OrthoDBiEOG6K6V53.

    Family and domain databases

    Gene3Di3.30.572.10. 1 hit.
    HAMAPiMF_00008. Thymidy_synth_bact.
    InterProiIPR023451. Thymidate_synth/dCMP_Mease.
    IPR000398. Thymidylate_synthase.
    [Graphical view]
    PfamiPF00303. Thymidylat_synt. 1 hit.
    [Graphical view]
    PRINTSiPR00108. THYMDSNTHASE.
    SUPFAMiSSF55831. SSF55831. 1 hit.
    TIGRFAMsiTIGR03284. thym_sym. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A8H1B4-1 [UniParc]FASTAAdd to Basket

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    MKQYLDLCQR LIDEGTWVEN SRTGKRCLTV INADLVYHVD KNEFPLITTR    50
    KSFYKAAIAE LLGYIRGYDN AADFRAIGCN TWNANANDNQ AWLDNPHRKG 100
    IDDMGRVYGV QGRAWSKPDG GCIDQLRKIV DDLSKGIDDR GEILSFYNPG 150
    EFHMGCLRPC MHTHNFSLVG DTLHLTSFQR SCDVPLGLNF NQVQVFTLLA 200
    LMAQITGHKP GTAFHKIVNA HIYEDQLELM QEVQLKREPF TSPKLVINPN 250
    IKSLEDLETW VSIDDFEVTG YEHHEAISYP FSV 283
    Length:283
    Mass (Da):32,211
    Last modified:November 13, 2007 - v1
    Checksum:i0F3F09D941B5F6F7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000851 Genomic DNA. Translation: ABV86351.1.
    RefSeqiWP_012154282.1. NC_009901.1.
    YP_001500886.1. NC_009901.1.

    Genome annotation databases

    EnsemblBacteriaiABV86351; ABV86351; Spea_1024.
    GeneIDi5661423.
    KEGGispl:Spea_1024.
    PATRICi23531729. VBIShePea72822_1067.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000851 Genomic DNA. Translation: ABV86351.1 .
    RefSeqi WP_012154282.1. NC_009901.1.
    YP_001500886.1. NC_009901.1.

    3D structure databases

    ProteinModelPortali A8H1B4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 398579.Spea_1024.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV86351 ; ABV86351 ; Spea_1024 .
    GeneIDi 5661423.
    KEGGi spl:Spea_1024.
    PATRICi 23531729. VBIShePea72822_1067.

    Phylogenomic databases

    eggNOGi COG0207.
    HOGENOMi HOG000257900.
    KOi K00560.
    OMAi DVHLYSN.
    OrthoDBi EOG6K6V53.

    Enzyme and pathway databases

    UniPathwayi UPA00575 .
    BioCyci SPEA398579:GHG5-1065-MONOMER.

    Family and domain databases

    Gene3Di 3.30.572.10. 1 hit.
    HAMAPi MF_00008. Thymidy_synth_bact.
    InterProi IPR023451. Thymidate_synth/dCMP_Mease.
    IPR000398. Thymidylate_synthase.
    [Graphical view ]
    Pfami PF00303. Thymidylat_synt. 1 hit.
    [Graphical view ]
    PRINTSi PR00108. THYMDSNTHASE.
    SUPFAMi SSF55831. SSF55831. 1 hit.
    TIGRFAMsi TIGR03284. thym_sym. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700345 / ANG-SQ1.

    Entry informationi

    Entry nameiTYSY_SHEPA
    AccessioniPrimary (citable) accession number: A8H1B4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3