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A8H0U0

- MDH_SHEPA

UniProt

A8H0U0 - MDH_SHEPA

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Protein

Malate dehydrogenase

Gene
mdh, Spea_0850
Organism
Shewanella pealeana (strain ATCC 700345 / ANG-SQ1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei34 – 341NAD By similarity
Binding sitei81 – 811Substrate By similarity
Binding sitei87 – 871Substrate By similarity
Binding sitei94 – 941NAD By similarity
Binding sitei119 – 1191Substrate By similarity
Binding sitei153 – 1531Substrate By similarity
Active sitei177 – 1771Proton acceptor By similarity
Binding sitei227 – 2271NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 137NAD By similarity
Nucleotide bindingi117 – 1193NAD By similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciSPEA398579:GHG5-890-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
Ordered Locus Names:Spea_0850
OrganismiShewanella pealeana (strain ATCC 700345 / ANG-SQ1)
Taxonomic identifieri398579 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000002608: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Malate dehydrogenaseUniRule annotationPRO_1000087540Add
BLAST

Proteomic databases

PRIDEiA8H0U0.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi398579.Spea_0850.

Structurei

3D structure databases

ProteinModelPortaliA8H0U0.
SMRiA8H0U0. Positions 1-310.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000213792.
KOiK00024.
OMAiVEVKGFA.
OrthoDBiEOG6091FG.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_01516. Malate_dehydrog_1.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR023958. Malate_DH_type1_bac.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8H0U0-1 [UniParc]FASTAAdd to Basket

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MKVAVLGAAG GIGQALALLL KTQLPAGSKL SLYDIAPVTP GVAVDLSHIP    50
TAVEVKGFAG EDPTAALEGA DVVLISAGVA RKPGMDRSDL FNINAGIVRN 100
LVEKCAATCP KALIGIITNP VNTTVAIAAE VLKNAGVYDK NRLFGVTTLD 150
VIRSETFVAE AKGLNVADVK VPVIGGHSGV TILPLLSQVE GVSFTDAEVA 200
ALTTRIQNAG TEVVEAKAGG GSATLSMGQA ACRFGLSLVR GLQGEANVVE 250
CAYVDGGSEH AEFFAQPVVL GKNGVEEVLA YGEVSAFEAN ARDAMLDTLQ 300
ADIQLGIDFV K 311
Length:311
Mass (Da):31,824
Last modified:November 13, 2007 - v1
Checksum:i2DD462CAF1CF4748
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000851 Genomic DNA. Translation: ABV86177.1.
RefSeqiWP_012154111.1. NC_009901.1.
YP_001500712.1. NC_009901.1.

Genome annotation databases

EnsemblBacteriaiABV86177; ABV86177; Spea_0850.
GeneIDi5661249.
KEGGispl:Spea_0850.
PATRICi23531363. VBIShePea72822_0885.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000851 Genomic DNA. Translation: ABV86177.1 .
RefSeqi WP_012154111.1. NC_009901.1.
YP_001500712.1. NC_009901.1.

3D structure databases

ProteinModelPortali A8H0U0.
SMRi A8H0U0. Positions 1-310.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 398579.Spea_0850.

Proteomic databases

PRIDEi A8H0U0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV86177 ; ABV86177 ; Spea_0850 .
GeneIDi 5661249.
KEGGi spl:Spea_0850.
PATRICi 23531363. VBIShePea72822_0885.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000213792.
KOi K00024.
OMAi VEVKGFA.
OrthoDBi EOG6091FG.

Enzyme and pathway databases

BioCyci SPEA398579:GHG5-890-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_01516. Malate_dehydrog_1.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR023958. Malate_DH_type1_bac.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEi PS00068. MDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700345 / ANG-SQ1.

Entry informationi

Entry nameiMDH_SHEPA
AccessioniPrimary (citable) accession number: A8H0U0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 13, 2007
Last modified: September 3, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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