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Protein

Exodeoxyribonuclease 7 large subunit

Gene

xseA

Organism
Rickettsia bellii (strain OSU 85-389)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.UniRule annotation

Catalytic activityi

Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
Exodeoxyribonuclease 7 large subunitUniRule annotation (EC:3.1.11.6UniRule annotation)
Alternative name(s):
Exodeoxyribonuclease VII large subunitUniRule annotation
Short name:
Exonuclease VII large subunitUniRule annotation
Gene namesi
Name:xseAUniRule annotation
Ordered Locus Names:A1I_06785
OrganismiRickettsia bellii (strain OSU 85-389)
Taxonomic identifieri391896 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000487811 – 442Exodeoxyribonuclease 7 large subunitAdd BLAST442

Interactioni

Subunit structurei

Heterooligomer composed of large and small subunits.UniRule annotation

Protein-protein interaction databases

STRINGi391896.A1I_06785.

Structurei

3D structure databases

ProteinModelPortaliA8GXS3.
SMRiA8GXS3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the XseA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DVS. Bacteria.
COG1570. LUCA.
HOGENOMiHOG000229266.
KOiK03601.
OMAiDKIHRYL.
OrthoDBiPOG091H02EK.

Family and domain databases

CDDicd04489. ExoVII_LU_OBF. 1 hit.
HAMAPiMF_00378. Exonuc_7_L. 1 hit.
InterProiIPR003753. Exonuc_VII_L.
IPR020579. Exonuc_VII_lsu_C.
IPR025824. OB-fold_nuc-bd_dom.
[Graphical view]
PfamiPF02601. Exonuc_VII_L. 1 hit.
PF13742. tRNA_anti_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00237. xseA. 1 hit.

Sequencei

Sequence statusi: Complete.

A8GXS3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDNFTSSQT TKEFSVSEIS NKIKELLENN FGYIKVKGEI SGLKIASSGH
60 70 80 90 100
AYFNLKENTA ILACTCWRPI LAKIKFPLND GMEVVISGKL SSYAGNSRYQ
110 120 130 140 150
LSVENLQPAG LGAMVQILNE RKARLEKEGL FNKIRKPIPF LPNKIGVITS
160 170 180 190 200
ITGAVIQDII HRIRERFPTH VIIWPVSVQG ENSGNEIAEA IDGFNKLEEA
210 220 230 240 250
NKPDVIIVAR GGGSIEDLWS FNDEVLVRAT YNSKIPIISA VGHEVDYTLI
260 270 280 290 300
DLAADKRAPT PTAAAEFAVP VRSILNSTLQ SYEKVLVTNT KQLVKNHEQA
310 320 330 340 350
ITNYDKINRY LAHYINHKQQ LLDETGFNLL DSLPCLISLK ETKLKSFSKE
360 370 380 390 400
RIHPHKIITY KTLELTHKAA YIIKSANNTL KNFEYKLELN SLLLLSLDYH
410 420 430 440
NVLKRGFAIV KGESGNFVSS KTTTEKVLNI QFFDGNIKAV RD
Length:442
Mass (Da):49,474
Last modified:November 13, 2007 - v1
Checksum:i0B31507C46A20525
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000849 Genomic DNA. Translation: ABV79673.1.
RefSeqiWP_011476902.1. NC_009883.1.

Genome annotation databases

EnsemblBacteriaiABV79673; ABV79673; A1I_06785.
KEGGirbo:A1I_06785.
PATRICi17880734. VBIRicBel35792_1416.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000849 Genomic DNA. Translation: ABV79673.1.
RefSeqiWP_011476902.1. NC_009883.1.

3D structure databases

ProteinModelPortaliA8GXS3.
SMRiA8GXS3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi391896.A1I_06785.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABV79673; ABV79673; A1I_06785.
KEGGirbo:A1I_06785.
PATRICi17880734. VBIRicBel35792_1416.

Phylogenomic databases

eggNOGiENOG4105DVS. Bacteria.
COG1570. LUCA.
HOGENOMiHOG000229266.
KOiK03601.
OMAiDKIHRYL.
OrthoDBiPOG091H02EK.

Family and domain databases

CDDicd04489. ExoVII_LU_OBF. 1 hit.
HAMAPiMF_00378. Exonuc_7_L. 1 hit.
InterProiIPR003753. Exonuc_VII_L.
IPR020579. Exonuc_VII_lsu_C.
IPR025824. OB-fold_nuc-bd_dom.
[Graphical view]
PfamiPF02601. Exonuc_VII_L. 1 hit.
PF13742. tRNA_anti_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00237. xseA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiEX7L_RICB8
AccessioniPrimary (citable) accession number: A8GXS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 13, 2007
Last modified: November 2, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.