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A8GXR7 (DER_RICB8) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
GTPase Der
Alternative name(s):
GTP-binding protein EngA
Gene names
Name:der
Synonyms:engA
Ordered Locus Names:A1I_06755
OrganismRickettsia bellii (strain OSU 85-389) [Complete proteome] [HAMAP]
Taxonomic identifier391896 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group

Protein attributes

Sequence length452 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

GTPase that plays an essential role in the late steps of ribosome biogenesis By similarity. HAMAP-Rule MF_00195

Subunit structure

Associates with the 50S ribosomal subunit By similarity.

Sequence similarities

Belongs to the Era/MnmE GTP-binding protein family. Der subfamily.

Contains 2 G (guanine nucleotide-binding) domains.

Contains 1 KH-like domain.

Ontologies

Keywords
   Biological processRibosome biogenesis
   DomainRepeat
   LigandGTP-binding
Nucleotide-binding
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processribosome biogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 452452GTPase Der HAMAP-Rule MF_00195
PRO_1000011724

Regions

Domain20 – 125106G 1
Domain196 – 304109G 2
Domain362 – 44887KH-like
Nucleotide binding15 – 228GTP 1 Potential
Nucleotide binding62 – 665GTP 1 Potential
Nucleotide binding124 – 1274GTP 1 Potential
Nucleotide binding191 – 1988GTP 2 Potential
Nucleotide binding238 – 2425GTP 2 Potential
Nucleotide binding303 – 3064GTP 2 Potential

Sequences

Sequence LengthMass (Da)Tools
A8GXR7 [UniParc].

Last modified November 13, 2007. Version 1.
Checksum: 0C982DEBDA80DE35

FASTA45251,145
        10         20         30         40         50         60 
MTKKIIAKKI IALVGRPNVG KSTLFNRLSM RKKAIVHDLP GVTRDRKYTD GRIGSFEFSL 

        70         80         90        100        110        120 
IDTPGFEENP DSFGKRLMEQ TTKAINEADL ICFMVDSRSG ILPDDKLLSD FVRKYNKPAV 

       130        140        150        160        170        180 
LVINKCEKAF DFDKEYYKLG FDSMVAISAE HGTGMIDLYD EIIAKLPEED SAEAEIHDPI 

       190        200        210        220        230        240 
KGDCLQIVVS GRPNAGKSTF INALINDERL LTGPEAGITR ESIEIDWQYK GNHIKLIDTA 

       250        260        270        280        290        300 
GLRKKATITE SLEKLSASDA INSIKFANTV ILMIDALSPL KQQDLNIASH VANEGRSIVI 

       310        320        330        340        350        360 
VVNKWDLIKE SEKEAFKEEF YYQINTTLPQ VKGVPALFIS AKNKQNIADV LDSCIKIYKT 

       370        380        390        400        410        420 
WNKKITTSKL NEWLNFTTEA HPLPLQKGGK RVRVKYMTQT KTRPPTFKLF SNNPEKITDS 

       430        440        450 
YTRYLVNNMR EAFDMPGVPI RFNYIKTKNP YV 

« Hide

References

[1]"Complete genome sequencing of Rickettsia bellii."
Madan A., Lee H., Madan A., Yoon J.-G., Ryu G.-Y., Dasch G., Ereemeva M.
Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: OSU 85-389.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000849 Genomic DNA. Translation: ABV79667.1.
RefSeqYP_001496704.1. NC_009883.1.

3D structure databases

ProteinModelPortalA8GXR7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING391896.A1I_06755.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABV79667; ABV79667; A1I_06755.
GeneID5646513.
KEGGrbo:A1I_06755.
PATRIC17880720. VBIRicBel35792_1409.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1160.
HOGENOMHOG000242862.
KOK03977.
OMAFSNNPEK.
OrthoDBEOG6DC6K1.
ProtClustDBPRK00093.

Enzyme and pathway databases

BioCycRBEL391896:GH75-1284-MONOMER.

Family and domain databases

Gene3D3.30.300.20. 1 hit.
3.40.50.300. 2 hits.
HAMAPMF_00195. GTPase_Der.
InterProIPR016484. GTP-bd_EngA.
IPR006073. GTP_binding_domain.
IPR015946. KH_dom-like_a/b.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
[Graphical view]
PfamPF01926. MMR_HSR1. 2 hits.
[Graphical view]
PIRSFPIRSF006485. GTP-binding_EngA. 1 hit.
PRINTSPR00326. GTP1OBG.
SUPFAMSSF52540. SSF52540. 2 hits.
TIGRFAMsTIGR03594. GTPase_EngA. 1 hit.
TIGR00231. small_GTP. 2 hits.
ProtoNetSearch...

Entry information

Entry nameDER_RICB8
AccessionPrimary (citable) accession number: A8GXR7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 13, 2007
Last modified: April 16, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families