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A8GVR9

- CLPX_RICB8

UniProt

A8GVR9 - CLPX_RICB8

Protein

ATP-dependent Clp protease ATP-binding subunit ClpX

Gene

clpX

Organism
Rickettsia bellii (strain OSU 85-389)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri12 – 3726C4-typeUniRule annotationAdd
    BLAST
    Nucleotide bindingi117 – 1248ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. nucleoside-triphosphatase activity Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. protein folding Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Chaperone

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciRBEL391896:GH75-544-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-dependent Clp protease ATP-binding subunit ClpXUniRule annotation
    Gene namesi
    Name:clpXUniRule annotation
    Ordered Locus Names:A1I_02875
    OrganismiRickettsia bellii (strain OSU 85-389)
    Taxonomic identifieri391896 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
    ProteomesiUP000001152: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 427427ATP-dependent Clp protease ATP-binding subunit ClpXPRO_1000024643Add
    BLAST

    Proteomic databases

    PRIDEiA8GVR9.

    Interactioni

    Subunit structurei

    Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.UniRule annotation

    Protein-protein interaction databases

    STRINGi391896.A1I_02875.

    Structurei

    3D structure databases

    ProteinModelPortaliA8GVR9.
    SMRiA8GVR9. Positions 8-48.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ClpX chaperone family.UniRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri12 – 3726C4-typeUniRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG1219.
    HOGENOMiHOG000010093.
    KOiK03544.
    OMAiKLFSMEG.
    OrthoDBiEOG625JZK.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_00175. ClpX.
    InterProiIPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR019489. Clp_ATPase_C.
    IPR004487. Clp_protease_ATP-bd_su_ClpX.
    IPR027417. P-loop_NTPase.
    IPR010603. Znf_CppX_C4.
    [Graphical view]
    PfamiPF07724. AAA_2. 1 hit.
    PF10431. ClpB_D2-small. 1 hit.
    PF06689. zf-C4_ClpX. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    SM01086. ClpB_D2-small. 1 hit.
    SM00994. zf-C4_ClpX. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00382. clpX. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A8GVR9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVVEANKKEL ICSFCSKKQH EVKKLIAGPA VFICDECINL CMDIMEEESK    50
    IALKQITSTI PTPQKICSVL NDYVVGQEQA KKVLAVAVYN HYKRLEYVQS 100
    GNNDVELNKS NILLIGPTGS GKTLLAQTLA KILDVPFTMA DATSLTEAGY 150
    VGEDVENILL RLLQAAEFNV AKAQKGIIYI DEVDKIARKS ENPSITRDVS 200
    GEGVQQALLK IMEGTVASVP PQGGRKHPQQ DFVQLDTSNI LFICGGAFMG 250
    IDSIITSRTN NSSIGFAANV NIDKEKINRE ILKSLEIEDL TKFGLIPEFI 300
    GRLPIVTTLD DLDKEALVTI LTKPKNAIVK QFKKQFELDE AELIVEDSAL 350
    EAIAEKALAK KTGARGLRSI IEHLLLDSMY KVAELKKQRV TITEDVVKGL 400
    IEPIITSIIT PTAKTSKKQA AVEDIPA 427
    Length:427
    Mass (Da):46,806
    Last modified:November 13, 2007 - v1
    Checksum:i51A5B5AF4F79E5B9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000849 Genomic DNA. Translation: ABV78946.1.
    RefSeqiYP_001495983.1. NC_009883.1.

    Genome annotation databases

    EnsemblBacteriaiABV78946; ABV78946; A1I_02875.
    GeneIDi5647076.
    KEGGirbo:A1I_02875.
    PATRICi17879048. VBIRicBel35792_0597.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000849 Genomic DNA. Translation: ABV78946.1 .
    RefSeqi YP_001495983.1. NC_009883.1.

    3D structure databases

    ProteinModelPortali A8GVR9.
    SMRi A8GVR9. Positions 8-48.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 391896.A1I_02875.

    Proteomic databases

    PRIDEi A8GVR9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV78946 ; ABV78946 ; A1I_02875 .
    GeneIDi 5647076.
    KEGGi rbo:A1I_02875.
    PATRICi 17879048. VBIRicBel35792_0597.

    Phylogenomic databases

    eggNOGi COG1219.
    HOGENOMi HOG000010093.
    KOi K03544.
    OMAi KLFSMEG.
    OrthoDBi EOG625JZK.

    Enzyme and pathway databases

    BioCyci RBEL391896:GH75-544-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_00175. ClpX.
    InterProi IPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR019489. Clp_ATPase_C.
    IPR004487. Clp_protease_ATP-bd_su_ClpX.
    IPR027417. P-loop_NTPase.
    IPR010603. Znf_CppX_C4.
    [Graphical view ]
    Pfami PF07724. AAA_2. 1 hit.
    PF10431. ClpB_D2-small. 1 hit.
    PF06689. zf-C4_ClpX. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    SM01086. ClpB_D2-small. 1 hit.
    SM00994. zf-C4_ClpX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00382. clpX. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequencing of Rickettsia bellii."
      Madan A., Lee H., Madan A., Yoon J.-G., Ryu G.-Y., Dasch G., Ereemeva M.
      Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: OSU 85-389.

    Entry informationi

    Entry nameiCLPX_RICB8
    AccessioniPrimary (citable) accession number: A8GVR9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3