A8GVR9 (CLPX_RICB8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ATP-dependent Clp protease ATP-binding subunit ClpX

Gene names

Name:	clpX
Ordered Locus Names:	A1I_02875

Organism

Rickettsia bellii (strain OSU 85-389) [Complete proteome] [HAMAP]

Taxonomic identifier

391896 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › belli group › Rickettsia bellii

Protein attributes

Sequence length	427 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP By similarity. HAMAP-Rule MF_00175
Subunit structure	Heterodimer of ClpP and ClpX By similarity.
Sequence similarities	Belongs to the ClpX chaperone family.

Ontologies

Keywords
Domain	Zinc-finger
Ligand	ATP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Chaperone
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	protein folding Inferred from electronic annotation. Source: HAMAP
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 427	427	ATP-dependent Clp protease ATP-binding subunit ClpX HAMAP-Rule MF_00175		PRO_1000024643
Regions
	Zinc finger	12 – 37	26	C4-type HAMAP-Rule MF_00175
	Nucleotide binding	116 – 123	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	A8GVR9 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: 51A5B5AF4F79E5B9	FASTA	427	46,806
	10 20 30 40 50 60 MVVEANKKEL ICSFCSKKQH EVKKLIAGPA VFICDECINL CMDIMEEESK IALKQITSTI 70 80 90 100 110 120 PTPQKICSVL NDYVVGQEQA KKVLAVAVYN HYKRLEYVQS GNNDVELNKS NILLIGPTGS 130 140 150 160 170 180 GKTLLAQTLA KILDVPFTMA DATSLTEAGY VGEDVENILL RLLQAAEFNV AKAQKGIIYI 190 200 210 220 230 240 DEVDKIARKS ENPSITRDVS GEGVQQALLK IMEGTVASVP PQGGRKHPQQ DFVQLDTSNI 250 260 270 280 290 300 LFICGGAFMG IDSIITSRTN NSSIGFAANV NIDKEKINRE ILKSLEIEDL TKFGLIPEFI 310 320 330 340 350 360 GRLPIVTTLD DLDKEALVTI LTKPKNAIVK QFKKQFELDE AELIVEDSAL EAIAEKALAK 370 380 390 400 410 420 KTGARGLRSI IEHLLLDSMY KVAELKKQRV TITEDVVKGL IEPIITSIIT PTAKTSKKQA AVEDIPA

References

[1]	"Complete genome sequencing of Rickettsia bellii." Madan A., Lee H., Madan A., Yoon J.-G., Ryu G.-Y., Dasch G., Ereemeva M. Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: OSU 85-389.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000849 Genomic DNA. Translation: ABV78946.1.
RefSeq	YP_001495983.1. NC_009883.1.
3D structure databases
ProteinModelPortal	A8GVR9.
SMR	A8GVR9. Positions 8-48.
ModBase	Search...
Protein-protein interaction databases
STRING	391896.A1I_02875.
Proteomic databases
PRIDE	A8GVR9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABV78946; ABV78946; A1I_02875.
GeneID	5647076.
KEGG	rbo:A1I_02875.
PATRIC	17879048. VBIRicBel35792_0597.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1219.
HOGENOM	HOG000010093.
KO	K03544.
OMA	SDLELEH.
ProtClustDB	PRK05342.
Enzyme and pathway databases
BioCyc	RBEL391896:GH75-570-MONOMER.
Family and domain databases
HAMAP	MF_00175. ClpX.
InterPro	IPR003593. AAA+_ATPase. IPR013093. ATPase_AAA-2. IPR019489. Clp_ATPase_C. IPR004487. Clp_protease_ATP-bd_su_ClpX. IPR010603. Znf_CppX_C4. [Graphical view]
PANTHER	PTHR11262:SF4. PTHR11262:SF4. 1 hit.
Pfam	PF07724. AAA_2. 1 hit. PF10431. ClpB_D2-small. 1 hit. PF06689. zf-C4_ClpX. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. SM01086. ClpB_D2-small. 1 hit. SM00994. zf-C4_ClpX. 1 hit. [Graphical view]
TIGRFAMs	TIGR00382. clpX. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CLPX_RICB8

Accession

Primary (citable) accession number: A8GVR9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 13, 2007
Last modified:	May 1, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program