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A8GVR9 (CLPX_RICB8) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ATP-dependent Clp protease ATP-binding subunit ClpX
Gene names
Name:clpX
Ordered Locus Names:A1I_02875
OrganismRickettsia bellii (strain OSU 85-389) [Complete proteome] [HAMAP]
Taxonomic identifier391896 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group

Protein attributes

Sequence length427 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP By similarity. HAMAP-Rule MF_00175

Subunit structure

Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes By similarity.

Sequence similarities

Belongs to the ClpX chaperone family.

Ontologies

Keywords
   DomainZinc-finger
   LigandATP-binding
Metal-binding
Nucleotide-binding
Zinc
   Molecular functionChaperone
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processprotein folding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

nucleoside-triphosphatase activity

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 427427ATP-dependent Clp protease ATP-binding subunit ClpX HAMAP-Rule MF_00175
PRO_1000024643

Regions

Zinc finger12 – 3726C4-type HAMAP-Rule MF_00175
Nucleotide binding117 – 1248ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A8GVR9 [UniParc].

Last modified November 13, 2007. Version 1.
Checksum: 51A5B5AF4F79E5B9

FASTA42746,806
        10         20         30         40         50         60 
MVVEANKKEL ICSFCSKKQH EVKKLIAGPA VFICDECINL CMDIMEEESK IALKQITSTI 

        70         80         90        100        110        120 
PTPQKICSVL NDYVVGQEQA KKVLAVAVYN HYKRLEYVQS GNNDVELNKS NILLIGPTGS 

       130        140        150        160        170        180 
GKTLLAQTLA KILDVPFTMA DATSLTEAGY VGEDVENILL RLLQAAEFNV AKAQKGIIYI 

       190        200        210        220        230        240 
DEVDKIARKS ENPSITRDVS GEGVQQALLK IMEGTVASVP PQGGRKHPQQ DFVQLDTSNI 

       250        260        270        280        290        300 
LFICGGAFMG IDSIITSRTN NSSIGFAANV NIDKEKINRE ILKSLEIEDL TKFGLIPEFI 

       310        320        330        340        350        360 
GRLPIVTTLD DLDKEALVTI LTKPKNAIVK QFKKQFELDE AELIVEDSAL EAIAEKALAK 

       370        380        390        400        410        420 
KTGARGLRSI IEHLLLDSMY KVAELKKQRV TITEDVVKGL IEPIITSIIT PTAKTSKKQA 


AVEDIPA 

« Hide

References

[1]"Complete genome sequencing of Rickettsia bellii."
Madan A., Lee H., Madan A., Yoon J.-G., Ryu G.-Y., Dasch G., Ereemeva M.
Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: OSU 85-389.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000849 Genomic DNA. Translation: ABV78946.1.
RefSeqYP_001495983.1. NC_009883.1.

3D structure databases

ProteinModelPortalA8GVR9.
SMRA8GVR9. Positions 8-48.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING391896.A1I_02875.

Proteomic databases

PRIDEA8GVR9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABV78946; ABV78946; A1I_02875.
GeneID5647076.
KEGGrbo:A1I_02875.
PATRIC17879048. VBIRicBel35792_0597.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1219.
HOGENOMHOG000010093.
KOK03544.
OMAKLFSMEG.
OrthoDBEOG625JZK.

Enzyme and pathway databases

BioCycRBEL391896:GH75-544-MONOMER.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_00175. ClpX.
InterProIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR019489. Clp_ATPase_C.
IPR004487. Clp_protease_ATP-bd_su_ClpX.
IPR027417. P-loop_NTPase.
IPR010603. Znf_CppX_C4.
[Graphical view]
PfamPF07724. AAA_2. 1 hit.
PF10431. ClpB_D2-small. 1 hit.
PF06689. zf-C4_ClpX. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
SM01086. ClpB_D2-small. 1 hit.
SM00994. zf-C4_ClpX. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00382. clpX. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCLPX_RICB8
AccessionPrimary (citable) accession number: A8GVR9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 13, 2007
Last modified: June 11, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families