A8GUZ2 (A8GUZ2_RICB8) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
UDP-3-O-acylglucosamine N-acyltransferase HAMAP MF_00523
EC=2.3.1.- HAMAP MF_00523

Gene names

Name:	lpxD HAMAP MF_00523 EMBL ABV78659.1
Ordered Locus Names:	A1I_01335

Organism

Rickettsia bellii (strain OSU 85-389) [Complete proteome] [HAMAP] EMBL ABV78659.1

Taxonomic identifier

391896 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia

Protein attributes

Sequence length	327 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP MF_00523
Catalytic activity	(3R)-3-hydroxyacyl-[acyl-carrier-protein] + UDP-3-O-acyl-alpha-D-glucosamine = UDP-2,3-diacyl-alpha-D-glucosamine + [acyl-carrier-protein]. HAMAP MF_00523 UDP-3-O-(3-hydroxytetradecanoyl)glucosamine + (R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] = UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + [acyl-carrier-protein]. SAAS SAAS020573
Pathway	Bacterial outer membrane biogenesis; LPS lipid A biosynthesis. HAMAP MF_00523 Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 3/6. SAAS SAAS020573
Subunit structure	Homotrimer By similarity. HAMAP MF_00523
Sequence similarities	Belongs to the transferase hexapeptide repeat family. LpxD subfamily. HAMAP MF_00523

Ontologies

Keywords
Biological process	Lipid A biosynthesis HAMAP MF_00523 SAAS SAAS020573 Lipid synthesis
Domain	Repeat HAMAP MF_00523 SAAS SAAS020573
Molecular function	Acyltransferase HAMAP MF_00523 SAAS SAAS020573 EMBL ABV78659.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	transferase activity, transferring acyl groups other than amino-acyl groups Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A8GUZ2 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: D9CCDB45BAC3EB5E	FASTA	327	34,808
	10 20 30 40 50 60 MAIADFLQDF IEAPKIHEDV AIHDIKILQE ASSNDISFLS NIKYSRFLKN TKAAACIVPK 70 80 90 100 110 120 DFTGEVNPNT VLLRAENSYF AYGKLIDFFY APVKSYPAKI MKSAYVAESA TIGKNCYVGH 130 140 150 160 170 180 NAVIEDNVVI GDDSIIEAGS FIGTGVVIGR NARIESNVSI NYSVIGDDVV ILSGAKIGQD 190 200 210 220 230 240 GFGFSTEKGM HHKIFHTGIV KIGNNVEIGA NTTIDRGSLQ DTIIEDLCRI DNLVQIGHSV 250 260 270 280 290 300 KIGKGSIIVA QAGIAGSSVI GKYCALGGQV GVAGHLYIGD GAQVAAQGGV AQNIEAGKIV 310 320 GGSPAVPIMD WHRQSIIMKQ LINKRSK

References

[1]	"Complete genome sequencing of Rickettsia bellii." Madan A., Lee H., Madan A., Yoon J.-G., Ryu G.-Y., Dasch G., Ereemeva M. Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: OSU 85-389 EMBL ABV78659.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000849 Genomic DNA. Translation: ABV78659.1.
RefSeq	YP_001495696.1. NC_009883.1.
3D structure databases
ProteinModelPortal	A8GUZ2.
ModBase	Search...
Protein-protein interaction databases
STRING	A8GUZ2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5647149.
GenomeReviews	Gene locus A1I_01335 in contig CP000849_GR.
KEGG	rbo:A1I_01335.
PATRIC	17878394. VBIRicBel35792_0279.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1044.
HOGENOM	HBG469615.
OMA	SYPAKIM.
ProtClustDB	PRK00892.
Enzyme and pathway databases
BioCyc	RBEL391896:A1I_01335-MONOMER.
Family and domain databases
HAMAP	MF_00523. LpxD. [Tree]
InterPro	IPR001451. Hexapep_transf. IPR011004. Trimer_LpxA-like. IPR007691. UDP-3-O_GlcNAc_AcTrfase. IPR020573. UDP_GlcNAc_AcTrfase_non-rep. [Graphical view]
KO	K02536.
Pfam	PF00132. Hexapep. 4 hits. PF04613. LpxD. 1 hit. [Graphical view]
SUPFAM	SSF51161. Trimer_LpxA_like. 1 hit.
TIGRFAMs	TIGR01853. Lipid_A_lpxD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A8GUZ2_RICB8

Accession

Primary (citable) accession number: A8GUZ2

Entry history

Integrated into UniProtKB/TrEMBL:	November 13, 2007
Last sequence update:	November 13, 2007
Last modified:	January 25, 2012
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)