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A8GUT7 (NADK_RICB8) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NAD kinase

EC=2.7.1.23
Alternative name(s):
ATP-dependent NAD kinase
Gene names
Name:nadK
Ordered Locus Names:A1I_01030
OrganismRickettsia bellii (strain OSU 85-389) [Complete proteome] [HAMAP]
Taxonomic identifier391896 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group

Protein attributes

Sequence length255 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity. HAMAP-Rule MF_00361

Catalytic activity

ATP + NAD+ = ADP + NADP+. HAMAP-Rule MF_00361

Cofactor

Divalent metal ions By similarity. HAMAP-Rule MF_00361

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00361.

Sequence similarities

Belongs to the NAD kinase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
NAD
NADP
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processNAD metabolic process

Inferred from electronic annotation. Source: InterPro

NADP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

NAD+ kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 255255NAD kinase HAMAP-Rule MF_00361
PRO_1000005439

Regions

Nucleotide binding44 – 452NAD By similarity
Nucleotide binding114 – 1152NAD By similarity
Nucleotide binding155 – 1606NAD By similarity

Sites

Active site441Proton acceptor By similarity
Binding site491NAD By similarity
Binding site1441NAD By similarity
Binding site1521NAD; via carbonyl oxygen By similarity
Binding site2161NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
A8GUT7 [UniParc].

Last modified November 13, 2007. Version 1.
Checksum: C609BC1260C882FA

FASTA25528,225
        10         20         30         40         50         60 
MNMNKIALVY NENSKSSSSI EEIKKLYTYC DVEDADVIMV AGGDGELLHN IHRYMHLNIP 

        70         80         90        100        110        120 
FYGVNLGSLG FLMNPLDIKN ILQNIQESTA STLNPLLMQA EDVDGQIHKA LAINEVSIFR 

       130        140        150        160        170        180 
KTNQAAKFRI EVNGVERMSE LVADGALVAT PAGSSAYNLS AGGHILPLES NMLCLTPICS 

       190        200        210        220        230        240 
FRPRRWHGAL LPSSASIKFE ILNTNKRPVN ATADFQEFSN IKSVTIKSTN DKSIKLLFNK 

       250 
NHTLEDRIIK EQFGG 

« Hide

References

[1]"Complete genome sequencing of Rickettsia bellii."
Madan A., Lee H., Madan A., Yoon J.-G., Ryu G.-Y., Dasch G., Ereemeva M.
Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: OSU 85-389.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000849 Genomic DNA. Translation: ABV78604.1.
RefSeqYP_001495641.1. NC_009883.1.

3D structure databases

ProteinModelPortalA8GUT7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING391896.A1I_01030.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABV78604; ABV78604; A1I_01030.
GeneID5646622.
KEGGrbo:A1I_01030.
PATRIC17878260. VBIRicBel35792_0213.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0061.
HOGENOMHOG000139847.
KOK00858.
OMAHESTVSI.
OrthoDBEOG6PZXDR.

Enzyme and pathway databases

BioCycRBEL391896:GH75-194-MONOMER.

Family and domain databases

Gene3D2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPMF_00361. NAD_kinase.
InterProIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERPTHR20275. PTHR20275. 1 hit.
PfamPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMSSF111331. SSF111331. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADK_RICB8
AccessionPrimary (citable) accession number: A8GUT7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 13, 2007
Last modified: July 9, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families