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A8GUS4

- A8GUS4_RICB8

UniProt

A8GUS4 - A8GUS4_RICB8

Protein

Alanine racemase

Gene

alr

Organism
Rickettsia bellii (strain OSU 85-389)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei83 – 831Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei182 – 1821SubstrateUniRule annotation
    Active sitei305 – 3051Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei353 – 3531Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciRBEL391896:GH75-161-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Name:alrImported
    Ordered Locus Names:A1I_00855Imported
    OrganismiRickettsia bellii (strain OSU 85-389)Imported
    Taxonomic identifieri391896 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
    ProteomesiUP000001152: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei83 – 831N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi391896.A1I_00855.

    Structurei

    3D structure databases

    ProteinModelPortaliA8GUS4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0787.
    HOGENOMiHOG000031445.
    KOiK01775.
    OMAiRIGISIY.
    OrthoDBiEOG6PP9NJ.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR029066. PLP-binding_barrel.
    IPR005728. Rickett_RPE.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    TIGR01045. RPE1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A8GUS4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLCTLEINL SAIKANYRLL KNICENSVDF LHNVANKEEF AGNTSPRTAA    50
    YTLVREDASL GSTPKLPLGA SYAKNLLVGA AVKANSYGLG AIEISKTLLE 100
    ENCRYFFVAS SNEGISLRKA IGDEVNILIL NGVFEHDALE LIEYNLIPVL 150
    NNLNQIKIWQ KFSNLKNQLL PCYLHFNTGI NRLGLNHNEI EQLINNRDLL 200
    KGLNVEYIIS HLSASEDSDN PYNLEQLNKF KAYLEYFPNA KASLANSGGI 250
    FLGKDYHFNL VRPGAALYGL NPLGSNKPNP MQNPVTLKAP IIHLQNLTYG 300
    SRIGYNMTFT TKRDSLIATL PFGYADGFSR NFSNQGTVFI NSRNVPIIGR 350
    ISMDLVNIDV TDLPPSDIFL GQEVEIIGNN CTPDKIADII GTIGYEILTS 400
    LGNRYKRIYT 410
    Length:410
    Mass (Da):45,476
    Last modified:November 13, 2007 - v1
    Checksum:i91E898D4A3B5E1B6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000849 Genomic DNA. Translation: ABV78571.1.
    RefSeqiWP_011477989.1. NC_009883.1.
    YP_001495608.1. NC_009883.1.

    Genome annotation databases

    EnsemblBacteriaiABV78571; ABV78571; A1I_00855.
    GeneIDi5647236.
    KEGGirbo:A1I_00855.
    PATRICi17878185. VBIRicBel35792_0176.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000849 Genomic DNA. Translation: ABV78571.1 .
    RefSeqi WP_011477989.1. NC_009883.1.
    YP_001495608.1. NC_009883.1.

    3D structure databases

    ProteinModelPortali A8GUS4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 391896.A1I_00855.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV78571 ; ABV78571 ; A1I_00855 .
    GeneIDi 5647236.
    KEGGi rbo:A1I_00855.
    PATRICi 17878185. VBIRicBel35792_0176.

    Phylogenomic databases

    eggNOGi COG0787.
    HOGENOMi HOG000031445.
    KOi K01775.
    OMAi RIGISIY.
    OrthoDBi EOG6PP9NJ.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci RBEL391896:GH75-161-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR029066. PLP-binding_barrel.
    IPR005728. Rickett_RPE.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    TIGR01045. RPE1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequencing of Rickettsia bellii."
      Madan A., Lee H., Madan A., Yoon J.-G., Ryu G.-Y., Dasch G., Ereemeva M.
      Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: OSU 85-389Imported.

    Entry informationi

    Entry nameiA8GUS4_RICB8
    AccessioniPrimary (citable) accession number: A8GUS4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 13, 2007
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3