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A8GUS4

- A8GUS4_RICB8

UniProt

A8GUS4 - A8GUS4_RICB8

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Protein

Alanine racemase

Gene
alr, A1I_00855
Organism
Rickettsia bellii (strain OSU 85-389)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei83 – 831Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei182 – 1821Substrate By similarityUniRule annotation
Active sitei305 – 3051Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei353 – 3531Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotationsImported

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciRBEL391896:GH75-161-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:A1I_00855Imported
OrganismiRickettsia bellii (strain OSU 85-389)Imported
Taxonomic identifieri391896 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
ProteomesiUP000001152: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei83 – 831N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi391896.A1I_00855.

Structurei

3D structure databases

ProteinModelPortaliA8GUS4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031445.
KOiK01775.
OMAiRIGISIY.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
IPR005728. Rickett_RPE.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
TIGR01045. RPE1. 1 hit.

Sequencei

Sequence statusi: Complete.

A8GUS4-1 [UniParc]FASTAAdd to Basket

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MSLCTLEINL SAIKANYRLL KNICENSVDF LHNVANKEEF AGNTSPRTAA    50
YTLVREDASL GSTPKLPLGA SYAKNLLVGA AVKANSYGLG AIEISKTLLE 100
ENCRYFFVAS SNEGISLRKA IGDEVNILIL NGVFEHDALE LIEYNLIPVL 150
NNLNQIKIWQ KFSNLKNQLL PCYLHFNTGI NRLGLNHNEI EQLINNRDLL 200
KGLNVEYIIS HLSASEDSDN PYNLEQLNKF KAYLEYFPNA KASLANSGGI 250
FLGKDYHFNL VRPGAALYGL NPLGSNKPNP MQNPVTLKAP IIHLQNLTYG 300
SRIGYNMTFT TKRDSLIATL PFGYADGFSR NFSNQGTVFI NSRNVPIIGR 350
ISMDLVNIDV TDLPPSDIFL GQEVEIIGNN CTPDKIADII GTIGYEILTS 400
LGNRYKRIYT 410
Length:410
Mass (Da):45,476
Last modified:November 13, 2007 - v1
Checksum:i91E898D4A3B5E1B6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000849 Genomic DNA. Translation: ABV78571.1.
RefSeqiWP_011477989.1. NC_009883.1.
YP_001495608.1. NC_009883.1.

Genome annotation databases

EnsemblBacteriaiABV78571; ABV78571; A1I_00855.
GeneIDi5647236.
KEGGirbo:A1I_00855.
PATRICi17878185. VBIRicBel35792_0176.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000849 Genomic DNA. Translation: ABV78571.1 .
RefSeqi WP_011477989.1. NC_009883.1.
YP_001495608.1. NC_009883.1.

3D structure databases

ProteinModelPortali A8GUS4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 391896.A1I_00855.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV78571 ; ABV78571 ; A1I_00855 .
GeneIDi 5647236.
KEGGi rbo:A1I_00855.
PATRICi 17878185. VBIRicBel35792_0176.

Phylogenomic databases

eggNOGi COG0787.
HOGENOMi HOG000031445.
KOi K01775.
OMAi RIGISIY.
OrthoDBi EOG6PP9NJ.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci RBEL391896:GH75-161-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
IPR005728. Rickett_RPE.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
TIGR01045. RPE1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequencing of Rickettsia bellii."
    Madan A., Lee H., Madan A., Yoon J.-G., Ryu G.-Y., Dasch G., Ereemeva M.
    Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OSU 85-389Imported.

Entry informationi

Entry nameiA8GUS4_RICB8
AccessioniPrimary (citable) accession number: A8GUS4
Entry historyi
Integrated into UniProtKB/TrEMBL: November 13, 2007
Last sequence update: November 13, 2007
Last modified: September 3, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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