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Protein

Alanine racemase

Gene

alr

Organism
Rickettsia bellii (strain OSU 85-389)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei83 – 831Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei182 – 1821SubstrateUniRule annotation
Active sitei305 – 3051Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei353 – 3531Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciRBEL391896:GH75-161-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:A1I_00855Imported
OrganismiRickettsia bellii (strain OSU 85-389)Imported
Taxonomic identifieri391896 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
ProteomesiUP000001152 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei83 – 831N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi391896.A1I_00855.

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031445.
KOiK01775.
OMAiWKGGAAI.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
IPR005728. Rickett_RPE.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
TIGR01045. RPE1. 1 hit.

Sequencei

Sequence statusi: Complete.

A8GUS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLCTLEINL SAIKANYRLL KNICENSVDF LHNVANKEEF AGNTSPRTAA
60 70 80 90 100
YTLVREDASL GSTPKLPLGA SYAKNLLVGA AVKANSYGLG AIEISKTLLE
110 120 130 140 150
ENCRYFFVAS SNEGISLRKA IGDEVNILIL NGVFEHDALE LIEYNLIPVL
160 170 180 190 200
NNLNQIKIWQ KFSNLKNQLL PCYLHFNTGI NRLGLNHNEI EQLINNRDLL
210 220 230 240 250
KGLNVEYIIS HLSASEDSDN PYNLEQLNKF KAYLEYFPNA KASLANSGGI
260 270 280 290 300
FLGKDYHFNL VRPGAALYGL NPLGSNKPNP MQNPVTLKAP IIHLQNLTYG
310 320 330 340 350
SRIGYNMTFT TKRDSLIATL PFGYADGFSR NFSNQGTVFI NSRNVPIIGR
360 370 380 390 400
ISMDLVNIDV TDLPPSDIFL GQEVEIIGNN CTPDKIADII GTIGYEILTS
410
LGNRYKRIYT
Length:410
Mass (Da):45,476
Last modified:November 13, 2007 - v1
Checksum:i91E898D4A3B5E1B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000849 Genomic DNA. Translation: ABV78571.1.
RefSeqiWP_011477989.1. NC_009883.1.
YP_001495608.1. NC_009883.1.

Genome annotation databases

EnsemblBacteriaiABV78571; ABV78571; A1I_00855.
KEGGirbo:A1I_00855.
PATRICi17878185. VBIRicBel35792_0176.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000849 Genomic DNA. Translation: ABV78571.1.
RefSeqiWP_011477989.1. NC_009883.1.
YP_001495608.1. NC_009883.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi391896.A1I_00855.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABV78571; ABV78571; A1I_00855.
KEGGirbo:A1I_00855.
PATRICi17878185. VBIRicBel35792_0176.

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031445.
KOiK01775.
OMAiWKGGAAI.
OrthoDBiEOG6PP9NJ.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciRBEL391896:GH75-161-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
IPR005728. Rickett_RPE.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
TIGR01045. RPE1. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequencing of Rickettsia bellii."
    Madan A., Lee H., Madan A., Yoon J.-G., Ryu G.-Y., Dasch G., Ereemeva M.
    Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OSU 85-389Imported.

Entry informationi

Entry nameiA8GUS4_RICB8
AccessioniPrimary (citable) accession number: A8GUS4
Entry historyi
Integrated into UniProtKB/TrEMBL: November 13, 2007
Last sequence update: November 13, 2007
Last modified: April 1, 2015
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.