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A8GUI1 (SYR_RICB8) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:A1I_00355
OrganismRickettsia bellii (strain OSU 85-389) [Complete proteome] [HAMAP]
Taxonomic identifier391896 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group

Protein attributes

Sequence length576 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 576576Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_1000018105

Regions

Motif126 – 13611"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
A8GUI1 [UniParc].

Last modified November 13, 2007. Version 1.
Checksum: 71CBAE5650F250B6

FASTA57665,078
        10         20         30         40         50         60 
MNIFNKLKHD IITASTQLYN NSEIANHASI ETPKDSFNGD LSSNIAMIIA AKKNVPPREV 

        70         80         90        100        110        120 
ALKFKEILNE LPYIASIEIA GPGFINFTIK ADSWHTAIKD ILQNESKFFE IDVDKNKNIN 

       130        140        150        160        170        180 
IEYVSANPTG PMHIGHARGA VYGDVLANIL KKVGYPVTKE YYVNDAGSQI NDLVSTVILR 

       190        200        210        220        230        240 
YREALGEKIT ITEGLYPGEY LIPVGQALAK EYGDKLLNMD ELERFKIVKN FAIQKMLDLN 

       250        260        270        280        290        300 
KEDLKELGVK HDVFFSEQTL HDNGKIEKTV KLLTDMGLIY EGSVPAPKGK VHAEWENRTQ 

       310        320        330        340        350        360 
ELFKSTKYGD DQDRPIRKAD GSWTYFASDL AYAKDKIDRG ANHLIYVLGA DHSGYVKRIE 

       370        380        390        400        410        420 
ATVKALGKEQ VKVDVKICQL VNFVENGVPV KMSKRLGTFA SVQDVNHEVG KDIIRFMMLT 

       430        440        450        460        470        480 
RENNKTLDFD LIKVKEQSKE NPIFYVQYAH VRTLSILSKA METIPQSYNS FEAGTYDLSL 

       490        500        510        520        530        540 
LSSEEEIEII KLLASWTKTL ETAAKYFEPH RVAFYLINLA SKFHALWNFG KENNDYRFII 

       550        560        570 
ENNVELTTAR LALAKAIQKI IASGLEVIGV EPMTRM 

« Hide

References

[1]"Complete genome sequencing of Rickettsia bellii."
Madan A., Lee H., Madan A., Yoon J.-G., Ryu G.-Y., Dasch G., Ereemeva M.
Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: OSU 85-389.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000849 Genomic DNA. Translation: ABV78477.1.
RefSeqYP_001495514.1. NC_009883.1.

3D structure databases

ProteinModelPortalA8GUI1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING391896.A1I_00355.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABV78477; ABV78477; A1I_00355.
GeneID5646745.
KEGGrbo:A1I_00355.
PATRIC17877981. VBIRicBel35792_0075.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0018.
HOGENOMHOG000247214.
KOK01887.
OMARFIMLTR.
OrthoDBEOG6JB13C.
ProtClustDBPRK01611.

Enzyme and pathway databases

BioCycRBEL391896:GH75-66-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_RICB8
AccessionPrimary (citable) accession number: A8GUI1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 13, 2007
Last modified: April 16, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries