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A8GU85

- LPXB_RICB8

UniProt

A8GU85 - LPXB_RICB8

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Rickettsia bellii (strain OSU 85-389)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciRBEL391896:GH75-976-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:A1I_05190
    OrganismiRickettsia bellii (strain OSU 85-389)
    Taxonomic identifieri391896 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
    ProteomesiUP000001152: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 381381Lipid-A-disaccharide synthasePRO_1000049412Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi391896.A1I_05190.

    Structurei

    3D structure databases

    ProteinModelPortaliA8GU85.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018004.
    KOiK00748.
    OMAiIARMLVN.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A8GU85-1 [UniParc]FASTAAdd to Basket

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    MKKIYFIAGE ASGDFAGGRI IRNLKADKEL KIIGIGGRNM EEAGNFESLF    50
    PISEINLMGF FEVIPHIFRI KKLINKTVED IIDNKPDILI TIDSPGFTYR 100
    VAAKVRERLP ELKMIHIVAP SVWAYKEGRA AKYAKIYNCL FALLPFEPPY 150
    FTKVGLDCRY IGHPIMEQEF YSDKVALRQE LEIDEDTKVL CVTLGSRKGE 200
    ILRHLPIFIP AIEKVYDDHK KKLMVIFPLA NPDHERIIKP FLEKVRFNYI 250
    FSYERLKSYA VSDLALAKSG TNTLEIAASG TPMIVAYKVN IFSFIIIRLL 300
    IKIKYVTLIN IIGNREIIPE FIQFNCEANL ISDKLKELLL NPQEVDKQIT 350
    ESHKILQELG FKSNIYPSYL ATKIIRQEFL K 381
    Length:381
    Mass (Da):43,782
    Last modified:November 13, 2007 - v1
    Checksum:iD0638A415D4C40DE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000849 Genomic DNA. Translation: ABV79367.1.
    RefSeqiWP_011477480.1. NC_009883.1.
    YP_001496404.1. NC_009883.1.

    Genome annotation databases

    EnsemblBacteriaiABV79367; ABV79367; A1I_05190.
    GeneIDi5646464.
    KEGGirbo:A1I_05190.
    PATRICi17880045. VBIRicBel35792_1080.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000849 Genomic DNA. Translation: ABV79367.1 .
    RefSeqi WP_011477480.1. NC_009883.1.
    YP_001496404.1. NC_009883.1.

    3D structure databases

    ProteinModelPortali A8GU85.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 391896.A1I_05190.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV79367 ; ABV79367 ; A1I_05190 .
    GeneIDi 5646464.
    KEGGi rbo:A1I_05190.
    PATRICi 17880045. VBIRicBel35792_1080.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018004.
    KOi K00748.
    OMAi IARMLVN.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci RBEL391896:GH75-976-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequencing of Rickettsia bellii."
      Madan A., Lee H., Madan A., Yoon J.-G., Ryu G.-Y., Dasch G., Ereemeva M.
      Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: OSU 85-389.

    Entry informationi

    Entry nameiLPXB_RICB8
    AccessioniPrimary (citable) accession number: A8GU85
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3