A8GTB0 (KTHY_RICRS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymidylate kinase
EC=2.7.4.9

Alternative name(s):
dTMP kinase

Gene names

Name:	tmk
Ordered Locus Names:	A1G_05815

Organism

Rickettsia rickettsii (strain Sheila Smith) [Complete proteome] [HAMAP]

Taxonomic identifier

392021 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group › Rickettsia rickettsii

Protein attributes

Sequence length	203 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis By similarity. HAMAP-Rule MF_00165
Catalytic activity	ATP + dTMP = ADP + dTDP. HAMAP-Rule MF_00165
Sequence similarities	Belongs to the thymidylate kinase family.

Ontologies

Keywords
Biological process	Nucleotide biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dTDP biosynthetic process Inferred from electronic annotation. Source: InterPro dTTP biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP thymidylate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 203	203	Thymidylate kinase HAMAP-Rule MF_00165		PRO_1000023271
Regions
	Nucleotide binding	14 – 21	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	A8GTB0 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: 2EE2A90360817B81	FASTA	203	23,477
	10 20 30 40 50 60 MNNLKQGKFI TFEGGEGIGK STQSQMLYEY LQSQNTPVIL TREVGGTIVA EKMREILVHE 70 80 90 100 110 120 ELLPMSELFQ AMAARYDHMA RKIIPALQEG HIVICDRFID STVCYQGLEL ENGIDLVYNL 130 140 150 160 170 180 HKTLMPSLMP DITFFIDVEP DTAIKRVNSR NMNNKFDIRG IDFYKKIYYC FKELSNRFPE 190 200 RIKTIKASDL SPLEVHELIK KHL

References

[1]	"Complete genome sequence of Rickettsia rickettsii." Madan A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Dasch G., Eremeeva M. Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Sheila Smith.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000848 Genomic DNA. Translation: ABV76635.1.
RefSeq	YP_001495143.1. NC_009882.1.
3D structure databases
ProteinModelPortal	A8GTB0.
ModBase	Search...
Protein-protein interaction databases
STRING	392021.A1G_05815.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABV76635; ABV76635; A1G_05815.
GeneID	5647424.
KEGG	rri:A1G_05815.
PATRIC	17905157. VBIRicRic5337_1222.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0125.
HOGENOM	HOG000229078.
KO	K00943.
OMA	IDLNRFA.
ProtClustDB	PRK00698.
Enzyme and pathway databases
BioCyc	RRIC392021:GIY1-1067-MONOMER.
Family and domain databases
HAMAP	MF_00165. Thymidylate_kinase.
InterPro	IPR027417. P-loop_NTPase. IPR018095. Thymidylate_kin_CS. IPR018094. Thymidylate_kinase. [Graphical view]
PANTHER	PTHR10344. PTHR10344. 1 hit.
SUPFAM	SSF52540. SSF52540. 1 hit.
TIGRFAMs	TIGR00041. DTMP_kinase. 1 hit.
PROSITE	PS01331. THYMIDYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KTHY_RICRS

Accession

Primary (citable) accession number: A8GTB0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 13, 2007
Last modified:	May 29, 2013
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program