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A8GTB0

- KTHY_RICRS

UniProt

A8GTB0 - KTHY_RICRS

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Protein

Thymidylate kinase

Gene

tmk

Organism
Rickettsia rickettsii (strain Sheila Smith)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.UniRule annotation

Catalytic activityi

ATP + dTMP = ADP + dTDP.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi14 – 218ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidylate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dTDP biosynthetic process Source: InterPro
  2. dTTP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRRIC392021:GIY1-1067-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate kinaseUniRule annotation (EC:2.7.4.9UniRule annotation)
Alternative name(s):
dTMP kinaseUniRule annotation
Gene namesi
Name:tmkUniRule annotation
Ordered Locus Names:A1G_05815
OrganismiRickettsia rickettsii (strain Sheila Smith)
Taxonomic identifieri392021 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000006832: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 203203Thymidylate kinasePRO_1000023271Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi392021.A1G_05815.

Structurei

3D structure databases

ProteinModelPortaliA8GTB0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0125.
HOGENOMiHOG000229078.
KOiK00943.
OMAiKSSHIDA.
OrthoDBiEOG64JFSH.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00165. Thymidylate_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR018095. Thymidylate_kin_CS.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.
PROSITEiPS01331. THYMIDYLATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8GTB0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNNLKQGKFI TFEGGEGIGK STQSQMLYEY LQSQNTPVIL TREVGGTIVA
60 70 80 90 100
EKMREILVHE ELLPMSELFQ AMAARYDHMA RKIIPALQEG HIVICDRFID
110 120 130 140 150
STVCYQGLEL ENGIDLVYNL HKTLMPSLMP DITFFIDVEP DTAIKRVNSR
160 170 180 190 200
NMNNKFDIRG IDFYKKIYYC FKELSNRFPE RIKTIKASDL SPLEVHELIK

KHL
Length:203
Mass (Da):23,477
Last modified:November 13, 2007 - v1
Checksum:i2EE2A90360817B81
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000848 Genomic DNA. Translation: ABV76635.1.
RefSeqiYP_001495143.1. NC_009882.1.

Genome annotation databases

EnsemblBacteriaiABV76635; ABV76635; A1G_05815.
GeneIDi5647424.
KEGGirri:A1G_05815.
PATRICi17905157. VBIRicRic5337_1222.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000848 Genomic DNA. Translation: ABV76635.1 .
RefSeqi YP_001495143.1. NC_009882.1.

3D structure databases

ProteinModelPortali A8GTB0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 392021.A1G_05815.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV76635 ; ABV76635 ; A1G_05815 .
GeneIDi 5647424.
KEGGi rri:A1G_05815.
PATRICi 17905157. VBIRicRic5337_1222.

Phylogenomic databases

eggNOGi COG0125.
HOGENOMi HOG000229078.
KOi K00943.
OMAi KSSHIDA.
OrthoDBi EOG64JFSH.

Enzyme and pathway databases

BioCyci RRIC392021:GIY1-1067-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00165. Thymidylate_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR018095. Thymidylate_kin_CS.
IPR018094. Thymidylate_kinase.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00041. DTMP_kinase. 1 hit.
PROSITEi PS01331. THYMIDYLATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Rickettsia rickettsii."
    Madan A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Dasch G., Eremeeva M.
    Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sheila Smith.

Entry informationi

Entry nameiKTHY_RICRS
AccessioniPrimary (citable) accession number: A8GTB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 13, 2007
Last modified: October 1, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3