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A8GTB0 (KTHY_RICRS) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidylate kinase

EC=2.7.4.9
Alternative name(s):
dTMP kinase
Gene names
Name:tmk
Ordered Locus Names:A1G_05815
OrganismRickettsia rickettsii (strain Sheila Smith) [Complete proteome] [HAMAP]
Taxonomic identifier392021 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length203 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis By similarity. HAMAP-Rule MF_00165

Catalytic activity

ATP + dTMP = ADP + dTDP. HAMAP-Rule MF_00165

Sequence similarities

Belongs to the thymidylate kinase family.

Ontologies

Keywords
   Biological processNucleotide biosynthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processdTDP biosynthetic process

Inferred from electronic annotation. Source: InterPro

dTTP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

thymidylate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 203203Thymidylate kinase HAMAP-Rule MF_00165
PRO_1000023271

Regions

Nucleotide binding14 – 218ATP Potential

Sequences

Sequence LengthMass (Da)Tools
A8GTB0 [UniParc].

Last modified November 13, 2007. Version 1.
Checksum: 2EE2A90360817B81

FASTA20323,477
        10         20         30         40         50         60 
MNNLKQGKFI TFEGGEGIGK STQSQMLYEY LQSQNTPVIL TREVGGTIVA EKMREILVHE 

        70         80         90        100        110        120 
ELLPMSELFQ AMAARYDHMA RKIIPALQEG HIVICDRFID STVCYQGLEL ENGIDLVYNL 

       130        140        150        160        170        180 
HKTLMPSLMP DITFFIDVEP DTAIKRVNSR NMNNKFDIRG IDFYKKIYYC FKELSNRFPE 

       190        200 
RIKTIKASDL SPLEVHELIK KHL 

« Hide

References

[1]"Complete genome sequence of Rickettsia rickettsii."
Madan A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Dasch G., Eremeeva M.
Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Sheila Smith.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000848 Genomic DNA. Translation: ABV76635.1.
RefSeqYP_001495143.1. NC_009882.1.

3D structure databases

ProteinModelPortalA8GTB0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING392021.A1G_05815.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABV76635; ABV76635; A1G_05815.
GeneID5647424.
KEGGrri:A1G_05815.
PATRIC17905157. VBIRicRic5337_1222.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0125.
HOGENOMHOG000229078.
KOK00943.
OMAMEAILFA.
OrthoDBEOG64JFSH.
ProtClustDBPRK00698.

Enzyme and pathway databases

BioCycRRIC392021:GIY1-1067-MONOMER.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
HAMAPMF_00165. Thymidylate_kinase.
InterProIPR027417. P-loop_NTPase.
IPR018095. Thymidylate_kin_CS.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00041. DTMP_kinase. 1 hit.
PROSITEPS01331. THYMIDYLATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKTHY_RICRS
AccessionPrimary (citable) accession number: A8GTB0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 13, 2007
Last modified: April 16, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families