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A8GRV2

- MDH_RICRS

UniProt

A8GRV2 - MDH_RICRS

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Protein
Malate dehydrogenase
Gene
mdh, A1G_02950
Organism
Rickettsia rickettsii (strain Sheila Smith)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei35 – 351NAD By similarity
Binding sitei84 – 841Substrate By similarity
Binding sitei90 – 901Substrate By similarity
Binding sitei97 – 971NAD By similarity
Binding sitei122 – 1221Substrate By similarity
Binding sitei153 – 1531Substrate By similarity
Active sitei177 – 1771Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 166NAD By similarity
Nucleotide bindingi120 – 1223NAD By similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciRRIC392021:GIY1-542-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
Ordered Locus Names:A1G_02950
OrganismiRickettsia rickettsii (strain Sheila Smith)
Taxonomic identifieri392021 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000006832: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Malate dehydrogenaseUniRule annotation
PRO_1000026491Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi392021.A1G_02950.

Structurei

3D structure databases

ProteinModelPortaliA8GRV2.
SMRiA8GRV2. Positions 1-314.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000213794.
KOiK00024.
OMAiYAPSAFV.
OrthoDBiEOG6091FG.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

A8GRV2-1 [UniParc]FASTAAdd to Basket

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MKQHPKISLI GSGNIGGTLA HLISLRELGN IVLFDVTEGV PQGKALDLMQ    50
AVTIAGSDIK IKGTNDYKDI KGSDAIIITA GLPRKPGMSR DDLISINTGI 100
MKTVAANVKK YAPDAFVIVI TNPLDVMVYV MLKESGLPHN KVIGMAGVLD 150
SSRFNLFLAE EFKVSVSNVN SMVLGGHGDA MVPLARYSTI SGVPIPDLIK 200
MGLSSNENIE KIIDRTRNGG GEIVALLKTG SAYYAPAASA IEMLESYLKD 250
KRQILTCAAY LQGEYGVHDL YVGVPIMIGK EGVLKVIELQ LTTEEKALFD 300
KSVEGVKKLI ETIK 314
Length:314
Mass (Da):33,714
Last modified:November 13, 2007 - v1
Checksum:i6421EB23A0783113
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000848 Genomic DNA. Translation: ABV76127.1.
RefSeqiYP_001494635.1. NC_009882.1.

Genome annotation databases

EnsemblBacteriaiABV76127; ABV76127; A1G_02950.
GeneIDi5648234.
KEGGirri:A1G_02950.
PATRICi17903911. VBIRicRic5337_0619.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000848 Genomic DNA. Translation: ABV76127.1 .
RefSeqi YP_001494635.1. NC_009882.1.

3D structure databases

ProteinModelPortali A8GRV2.
SMRi A8GRV2. Positions 1-314.
ModBasei Search...

Protein-protein interaction databases

STRINGi 392021.A1G_02950.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV76127 ; ABV76127 ; A1G_02950 .
GeneIDi 5648234.
KEGGi rri:A1G_02950.
PATRICi 17903911. VBIRicRic5337_0619.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000213794.
KOi K00024.
OMAi YAPSAFV.
OrthoDBi EOG6091FG.

Enzyme and pathway databases

BioCyci RRIC392021:GIY1-542-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_00487. Malate_dehydrog_3.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Rickettsia rickettsii."
    Madan A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Dasch G., Eremeeva M.
    Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sheila Smith.

Entry informationi

Entry nameiMDH_RICRS
AccessioniPrimary (citable) accession number: A8GRV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 13, 2007
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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