Reviewed, UniProtKB/Swiss-Prot A8GQB7 (HEM6_RICAH)

Names and origin

Protein names

Recommended name:
    Coproporphyrinogen III oxidase, aerobic
      Short name=Coproporphyrinogenase
      Short name=Coprogen oxidase
    EC=1.3.3.3

Gene names

Name:	hemF
Ordered Locus Names:	A1C_06860

Organism

Rickettsia akari (strain Hartford) [Complete proteome] [HAMAP]

Taxonomic identifier

293614 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group

Protein attributes

Sequence length	279 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Coproporphyrinogen-III + O(2) + 2 H(+) = protoporphyrinogen-IX + 2 CO(2) + 2 H(2)O.
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen III (O2 route): step 1/1.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the aerobic coproporphyrinogen III oxidase family.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW porphyrin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	coproporphyrinogen oxidase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 279	279	Coproporphyrinogen III oxidase, aerobic		PRO_1000019492

Sequences

	Sequence		Length	Mass (Da)
	A8GQB7-1 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: B2D0E1E54E8A1B1D	FASTA	279	32,097
	10 20 30 40 50 60 MKIENKEITS NWFTNLRDLL CKEFEKIEEE YAQTKCLKPA KFVRTSWQRN GGGGGIMSLM 70 80 90 100 110 120 KGEVFEKVGV NISTVFGEFS PEFRSEIPGA ELDGKFSATG ISLVAHLKSP LIPAMHFNTR 130 140 150 160 170 180 YIETSKSWFG GGGDLTPFYP EENETEKFHA AFKEACDKYD SGYYPKFKKQ CDEYFYLKHR 190 200 210 220 230 240 KEPRGVGGIF YDYLNSGNFE QDFSFTQDVG MALLSVYPEI VRSKLFLPWT AEQKEYQLIR 250 260 270 RGRYVEFNLL YDRGTKFGLM TDGNVEAILM SLPPEVKFN

References

[1]	"Complete genome sequence of Rickettsia akari." Madan A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Dasch G., Eremeeva M. Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000847 Genomic DNA. Translation: ABV75592.1.
RefSeq	YP_001494100.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5645040.
GenomeReviews	Gene locus A1C_06860 in contig CP000847_GR.
KEGG	rak:A1C_06860.
NMPDR	fig|293614.3.peg.1297.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00333. [Tree]
InterPro	IPR001260. Coprogen_oxidas. [Graphical view]
Gene3D	G3DSA:3.40.1500.10. Coprogen_oxidas. 1 hit.
PANTHER	PTHR10755. Coprogen_oxidas. 1 hit.
Pfam	PF01218. Coprogen_oxidas. 1 hit. [Graphical view]
PIRSF	PIRSF000166. Coproporphyri_ox. 1 hit.
PRINTS	PR00073. COPRGNOXDASE.
PROSITE	PS01021. COPROGEN_OXIDASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HEM6_RICAH

Accession

Primary (citable) accession number: A8GQB7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 13, 2007
Last modified:	November 4, 2008
This is version 10 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)