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A8GNE3

- SYL_RICAH

UniProt

A8GNE3 - SYL_RICAH

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Rickettsia akari (strain Hartford)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei605 – 6051ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRAKA293614:GI4A-594-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:A1C_03160
    OrganismiRickettsia akari (strain Hartford)
    Taxonomic identifieri293614 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000006830: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 870870Leucine--tRNA ligasePRO_1000009416Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi293614.A1C_03160.

    Structurei

    3D structure databases

    ProteinModelPortaliA8GNE3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi36 – 4611"HIGH" regionAdd
    BLAST
    Motifi602 – 6065"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHELEVYT.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR005728. Rickett_RPE.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 2 hits.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    TIGR01045. RPE1. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8GNE3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNQIEQKWQQ IWHDEKAFEV SNESSKPKYY VLAMLPYPSG KIHLGHVRNY    50
    SIGDVIARFM TMQGFNVLHP MGWDAFGLPA ENAAIKNNSH PKDWTYSNIE 100
    NMKKQLKSMG FSYAWSREIN SCDPQYYKHE QKFFLELYER NLAYQKESLV 150
    NWDPVDNTVL ANEQVVDGRG WRSGAVVEKR YLKQWFLKIT DYAEELLNEI 200
    QNLKEWPEAV RSMQEKWIGK SIGANFHFKI KDNEDTTIEV FSTKPETIFG 250
    AGFIGIAFNH PIIERLVSKT PEISNFIAKC ANITCSVELD KAEKEGVFTG 300
    LYVTHPFDSN IVLPVIITNF VLMDYGTGAV FGCPAHDERD HELAVKMNLT 350
    IKKVIETDID VQKTPYTEDG ILVNSNFLNG LTSNEAKQKV IEEFEKLEIG 400
    KCTINYRLKD WGISRQRFWG CPIPMIHCEA CGIVPVPYKD LPVTLPDDVS 450
    FDGHGNPLAH HPSWKHVNCP KCNKPAIRET DTFDTFFESS WYFTRYCNSN 500
    ATEMTDKKAC DYWLPVDKYI GGIEHAVMHL LYARFFTKVM NEQHYVSVRE 550
    PFKGLFTQGM VLHATYKDEH NNWLYPEEVV KKGNEFFRKE SNDRVVQGRI 600
    EKMSKSKKNL IDLETMQKQY GADAIRLFVL SDSPPEKDLE WFVSGIEGCS 650
    RFINKLEQMF EAIKFLYNEA NKEEFEGNTE RSTAAYTLVR EDASTGSMYK 700
    LPLEASYINK ELNRLVHFTI KHVAEDIKHF ALNRAIARMR ELANAISSEI 750
    SKDKIDVNTV RHGFNILVQL LNPFIPHITE EIWQKLGNKE RLYKSDFPAF 800
    DESMLELDTY IMAVQVNGKL RDTYKFKTAA SEDAIKQITV NLPKVQKFLA 850
    GKEPKKIILV PRKIVNIIVN 870
    Length:870
    Mass (Da):100,472
    Last modified:November 13, 2007 - v1
    Checksum:iBD373D1DAB2FC9D3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000847 Genomic DNA. Translation: ABV74918.1.
    RefSeqiYP_001493426.1. NC_009881.1.

    Genome annotation databases

    EnsemblBacteriaiABV74918; ABV74918; A1C_03160.
    GeneIDi5644803.
    KEGGirak:A1C_03160.
    PATRICi17876213. VBIRicAka50705_0654.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000847 Genomic DNA. Translation: ABV74918.1 .
    RefSeqi YP_001493426.1. NC_009881.1.

    3D structure databases

    ProteinModelPortali A8GNE3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 293614.A1C_03160.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV74918 ; ABV74918 ; A1C_03160 .
    GeneIDi 5644803.
    KEGGi rak:A1C_03160.
    PATRICi 17876213. VBIRicAka50705_0654.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HELEVYT.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci RAKA293614:GI4A-594-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR005728. Rickett_RPE.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 2 hits.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    TIGR01045. RPE1. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Rickettsia akari."
      Madan A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Dasch G., Eremeeva M.
      Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Hartford.

    Entry informationi

    Entry nameiSYL_RICAH
    AccessioniPrimary (citable) accession number: A8GNE3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3