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A8GNE3

- SYL_RICAH

UniProt

A8GNE3 - SYL_RICAH

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Protein
Leucine--tRNA ligase
Gene
leuS, A1C_03160
Organism
Rickettsia akari (strain Hartford)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei605 – 6051ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRAKA293614:GI4A-594-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:A1C_03160
OrganismiRickettsia akari (strain Hartford)
Taxonomic identifieri293614 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000006830: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 870870Leucine--tRNA ligaseUniRule annotation
PRO_1000009416Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi293614.A1C_03160.

Structurei

3D structure databases

ProteinModelPortaliA8GNE3.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi36 – 4611"HIGH" regionUniRule annotation
Add
BLAST
Motifi602 – 6065"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHELEVYT.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR005728. Rickett_RPE.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 2 hits.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
TIGR01045. RPE1. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8GNE3-1 [UniParc]FASTAAdd to Basket

« Hide

MNQIEQKWQQ IWHDEKAFEV SNESSKPKYY VLAMLPYPSG KIHLGHVRNY    50
SIGDVIARFM TMQGFNVLHP MGWDAFGLPA ENAAIKNNSH PKDWTYSNIE 100
NMKKQLKSMG FSYAWSREIN SCDPQYYKHE QKFFLELYER NLAYQKESLV 150
NWDPVDNTVL ANEQVVDGRG WRSGAVVEKR YLKQWFLKIT DYAEELLNEI 200
QNLKEWPEAV RSMQEKWIGK SIGANFHFKI KDNEDTTIEV FSTKPETIFG 250
AGFIGIAFNH PIIERLVSKT PEISNFIAKC ANITCSVELD KAEKEGVFTG 300
LYVTHPFDSN IVLPVIITNF VLMDYGTGAV FGCPAHDERD HELAVKMNLT 350
IKKVIETDID VQKTPYTEDG ILVNSNFLNG LTSNEAKQKV IEEFEKLEIG 400
KCTINYRLKD WGISRQRFWG CPIPMIHCEA CGIVPVPYKD LPVTLPDDVS 450
FDGHGNPLAH HPSWKHVNCP KCNKPAIRET DTFDTFFESS WYFTRYCNSN 500
ATEMTDKKAC DYWLPVDKYI GGIEHAVMHL LYARFFTKVM NEQHYVSVRE 550
PFKGLFTQGM VLHATYKDEH NNWLYPEEVV KKGNEFFRKE SNDRVVQGRI 600
EKMSKSKKNL IDLETMQKQY GADAIRLFVL SDSPPEKDLE WFVSGIEGCS 650
RFINKLEQMF EAIKFLYNEA NKEEFEGNTE RSTAAYTLVR EDASTGSMYK 700
LPLEASYINK ELNRLVHFTI KHVAEDIKHF ALNRAIARMR ELANAISSEI 750
SKDKIDVNTV RHGFNILVQL LNPFIPHITE EIWQKLGNKE RLYKSDFPAF 800
DESMLELDTY IMAVQVNGKL RDTYKFKTAA SEDAIKQITV NLPKVQKFLA 850
GKEPKKIILV PRKIVNIIVN 870
Length:870
Mass (Da):100,472
Last modified:November 13, 2007 - v1
Checksum:iBD373D1DAB2FC9D3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000847 Genomic DNA. Translation: ABV74918.1.
RefSeqiYP_001493426.1. NC_009881.1.

Genome annotation databases

EnsemblBacteriaiABV74918; ABV74918; A1C_03160.
GeneIDi5644803.
KEGGirak:A1C_03160.
PATRICi17876213. VBIRicAka50705_0654.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000847 Genomic DNA. Translation: ABV74918.1 .
RefSeqi YP_001493426.1. NC_009881.1.

3D structure databases

ProteinModelPortali A8GNE3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 293614.A1C_03160.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV74918 ; ABV74918 ; A1C_03160 .
GeneIDi 5644803.
KEGGi rak:A1C_03160.
PATRICi 17876213. VBIRicAka50705_0654.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HELEVYT.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci RAKA293614:GI4A-594-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR005728. Rickett_RPE.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 2 hits.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
TIGR01045. RPE1. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Rickettsia akari."
    Madan A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Dasch G., Eremeeva M.
    Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Hartford.

Entry informationi

Entry nameiSYL_RICAH
AccessioniPrimary (citable) accession number: A8GNE3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 13, 2007
Last modified: May 14, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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