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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Rickettsia akari (strain Hartford)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei605ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRAKA293614:G1GA4-566-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:A1C_03160
OrganismiRickettsia akari (strain Hartford)
Taxonomic identifieri293614 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000006830 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000094161 – 870Leucine--tRNA ligaseAdd BLAST870

Proteomic databases

PRIDEiA8GNE3

Interactioni

Protein-protein interaction databases

STRINGi293614.A1C_03160

Structurei

3D structure databases

ProteinModelPortaliA8GNE3
SMRiA8GNE3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi36 – 46"HIGH" regionAdd BLAST11
Motifi602 – 606"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR005728 Rickett_RPE
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 3 hits
PF13603 tRNA-synt_1_2, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 2 hits
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
TIGR01045 RPE1, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A8GNE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQIEQKWQQ IWHDEKAFEV SNESSKPKYY VLAMLPYPSG KIHLGHVRNY
60 70 80 90 100
SIGDVIARFM TMQGFNVLHP MGWDAFGLPA ENAAIKNNSH PKDWTYSNIE
110 120 130 140 150
NMKKQLKSMG FSYAWSREIN SCDPQYYKHE QKFFLELYER NLAYQKESLV
160 170 180 190 200
NWDPVDNTVL ANEQVVDGRG WRSGAVVEKR YLKQWFLKIT DYAEELLNEI
210 220 230 240 250
QNLKEWPEAV RSMQEKWIGK SIGANFHFKI KDNEDTTIEV FSTKPETIFG
260 270 280 290 300
AGFIGIAFNH PIIERLVSKT PEISNFIAKC ANITCSVELD KAEKEGVFTG
310 320 330 340 350
LYVTHPFDSN IVLPVIITNF VLMDYGTGAV FGCPAHDERD HELAVKMNLT
360 370 380 390 400
IKKVIETDID VQKTPYTEDG ILVNSNFLNG LTSNEAKQKV IEEFEKLEIG
410 420 430 440 450
KCTINYRLKD WGISRQRFWG CPIPMIHCEA CGIVPVPYKD LPVTLPDDVS
460 470 480 490 500
FDGHGNPLAH HPSWKHVNCP KCNKPAIRET DTFDTFFESS WYFTRYCNSN
510 520 530 540 550
ATEMTDKKAC DYWLPVDKYI GGIEHAVMHL LYARFFTKVM NEQHYVSVRE
560 570 580 590 600
PFKGLFTQGM VLHATYKDEH NNWLYPEEVV KKGNEFFRKE SNDRVVQGRI
610 620 630 640 650
EKMSKSKKNL IDLETMQKQY GADAIRLFVL SDSPPEKDLE WFVSGIEGCS
660 670 680 690 700
RFINKLEQMF EAIKFLYNEA NKEEFEGNTE RSTAAYTLVR EDASTGSMYK
710 720 730 740 750
LPLEASYINK ELNRLVHFTI KHVAEDIKHF ALNRAIARMR ELANAISSEI
760 770 780 790 800
SKDKIDVNTV RHGFNILVQL LNPFIPHITE EIWQKLGNKE RLYKSDFPAF
810 820 830 840 850
DESMLELDTY IMAVQVNGKL RDTYKFKTAA SEDAIKQITV NLPKVQKFLA
860 870
GKEPKKIILV PRKIVNIIVN
Length:870
Mass (Da):100,472
Last modified:November 13, 2007 - v1
Checksum:iBD373D1DAB2FC9D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000847 Genomic DNA Translation: ABV74918.1
RefSeqiWP_012149551.1, NC_009881.1

Genome annotation databases

EnsemblBacteriaiABV74918; ABV74918; A1C_03160
KEGGirak:A1C_03160

Similar proteinsi

Entry informationi

Entry nameiSYL_RICAH
AccessioniPrimary (citable) accession number: A8GNE3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 13, 2007
Last modified: May 23, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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