A8GN89 (GCH1_RICAH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GTP cyclohydrolase 1
EC=3.5.4.16

Alternative name(s):
GTP cyclohydrolase I
Short name=GTP-CH-I

Gene names

Name:	folE
Ordered Locus Names:	A1C_02870

Organism

Rickettsia akari (strain Hartford) [Complete proteome] [HAMAP]

Taxonomic identifier

293614 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group › Rickettsia akari

Protein attributes

Sequence length	190 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_00223
Pathway	Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_00223
Subunit structure	Toroid-shaped homodecamer, composed of two pentamers of five dimers By similarity.
Sequence similarities	Belongs to the GTP cyclohydrolase I family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Ligand	GTP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	7,8-dihydroneopterin 3'-triphosphate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP tetrahydrofolate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTP cyclohydrolase I activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 190	190	GTP cyclohydrolase 1 HAMAP-Rule MF_00223		PRO_1000043723
Sites
	Metal binding	80	1	Zinc By similarity
	Metal binding	83	1	Zinc By similarity
	Metal binding	151	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	A8GN89 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: 9034C865493FBCBB	FASTA	190	21,754
	10 20 30 40 50 60 MSKPTREEAT EAVRTLLKFI GEDPTREGLL KTPDRVINSY TEIFSGYGKD VEEILNTKFY 70 80 90 100 110 120 DTCNFQDFIS LEGIKFTSFC EHHMLPFNGT VHIAYIPDNC IVGISKLARI VNIFAKRLQI 130 140 150 160 170 180 QEKMTVQIAE SVQENLKPLG VAVKIAALHS CMSMRGVMQD HSIMNTMHYT GIFAEQQKYR 190 HEFLNLTTKR

References

[1]	"Complete genome sequence of Rickettsia akari." Madan A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Dasch G., Eremeeva M. Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Hartford.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000847 Genomic DNA. Translation: ABV74864.1.
RefSeq	YP_001493372.1. NC_009881.1.
3D structure databases
ProteinModelPortal	A8GN89.
ModBase	Search...
Protein-protein interaction databases
STRING	293614.A1C_02870.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABV74864; ABV74864; A1C_02870.
GeneID	5645827.
KEGG	rak:A1C_02870.
PATRIC	17876087. VBIRicAka50705_0591.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0302.
HOGENOM	HOG000221222.
KO	K01495.
OMA	LLWVGEN.
ProtClustDB	PRK09347.
Enzyme and pathway databases
BioCyc	RAKA293614:GI4A-562-MONOMER.
UniPathway	UPA00848; UER00151.
Family and domain databases
HAMAP	MF_00223. FolE.
InterPro	IPR001474. GTP_CycHdrlase_I. IPR020602. GTP_CycHdrlase_I/CN_OxRdtase. IPR018234. GTP_CycHdrlase_I_CS. [Graphical view]
PANTHER	PTHR11109. PTHR11109. 1 hit.
Pfam	PF01227. GTP_cyclohydroI. 1 hit. [Graphical view]
TIGRFAMs	TIGR00063. folE. 1 hit.
PROSITE	PS00859. GTP_CYCLOHYDROL_1_1. 1 hit. PS00860. GTP_CYCLOHYDROL_1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCH1_RICAH

Accession

Primary (citable) accession number: A8GN89

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 13, 2007
Last modified:	May 1, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program