UniProtKB - A8GN11 (SYE1_RICAH)
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Protein
Glutamate--tRNA ligase 1
Gene
gltX1
Organism
Rickettsia akari (strain Hartford)
Status
Functioni
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation
Catalytic activityi
ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 243 | ATPUniRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- glutamate-tRNA ligase activity Source: UniProtKB-EC
- tRNA binding Source: InterPro
GO - Biological processi
- glutamyl-tRNA aminoacylation Source: InterPro
Keywordsi
Molecular function | Aminoacyl-tRNA synthetase, Ligase |
Biological process | Protein biosynthesis |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | RAKA293614:G1GA4-433-MONOMER. |
Names & Taxonomyi
Protein namesi | Recommended name: Glutamate--tRNA ligase 1UniRule annotation (EC:6.1.1.17UniRule annotation)Alternative name(s): Glutamyl-tRNA synthetase 1UniRule annotation Short name: GluRS 1UniRule annotation |
Gene namesi | Name:gltX1UniRule annotation Ordered Locus Names:A1C_02435 |
Organismi | Rickettsia akari (strain Hartford) |
Taxonomic identifieri | 293614 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000367752 | 1 – 447 | Glutamate--tRNA ligase 1Add BLAST | 447 |
Interactioni
Subunit structurei
Monomer.UniRule annotation
Protein-protein interaction databases
STRINGi | 293614.A1C_02435. |
Structurei
3D structure databases
ProteinModelPortali | A8GN11. |
SMRi | A8GN11. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 10 – 20 | "HIGH" regionUniRule annotationAdd BLAST | 11 | |
Motifi | 240 – 244 | "KMSKS" regionUniRule annotation | 5 |
Sequence similaritiesi
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation
Phylogenomic databases
eggNOGi | ENOG4105C20. Bacteria. COG0008. LUCA. |
HOGENOMi | HOG000252721. |
KOi | K01885. |
OMAi | LYPCYET. |
OrthoDBi | POG091H021W. |
Family and domain databases
Gene3Di | 1.10.10.350. 1 hit. 3.40.50.620. 1 hit. |
HAMAPi | MF_00022. Glu_tRNA_synth_type1. 1 hit. |
InterProi | View protein in InterPro IPR008925. aa-tRNA-synth_I_codon-bd. IPR020751. aa-tRNA-synth_I_codon-bd_sub2. IPR001412. aa-tRNA-synth_I_CS. IPR004527. Glu-tRNA-ligase_bac/mito. IPR000924. Glu/Gln-tRNA-synth. IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom. IPR014729. Rossmann-like_a/b/a_fold. |
Pfami | View protein in Pfam PF00749. tRNA-synt_1c. 1 hit. |
PRINTSi | PR00987. TRNASYNTHGLU. |
SUPFAMi | SSF48163. SSF48163. 1 hit. |
TIGRFAMsi | TIGR00464. gltX_bact. 1 hit. |
PROSITEi | View protein in PROSITE PS00178. AA_TRNA_LIGASE_I. 1 hit. |
i Sequence
Sequence statusi: Complete.
A8GN11-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTKVITRFAP SPTGMLHVGN IRVALLNWLY AKKHNGQFIL RFDDTDLERS
60 70 80 90 100
KQEYKDAIKD DLKFLNLHWD QTFNQLSRLS RYDEIKNLLL DKKRLYACYE
110 120 130 140 150
TPDELELKRK FQLSKGLPPM YDRASLNLTE EQTEKYIEQG RNPHYRFLVN
160 170 180 190 200
HEPISWHDMI KGEIQYDGKA LSDPIVIRAD GSMTYMLCSV IDDIDYDITH
210 220 230 240 250
IIRGEDHVSN TAIQIQMFEA LNNTPTTFGH LSLIINKDEK ISKRVGGFEI
260 270 280 290 300
TTLRKEIGIE AMAIASFFSL LGSSAQILPY KSMEKLINQF EISSFSKSPT
310 320 330 340 350
IYQPKDLERL NHKLLISLDF DEVKDHLKEI DAEYIDENFW LSIRPNLQKL
360 370 380 390 400
RDVKDWWEIC HHTPNVESLN LDQEYLKQAA ELLPQGAITK DSWSIWTKEI
410 420 430 440
TNITGRKGKE LFLPLRLALT GRESGPEIAD VLPLISREEI VKRLTSA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000847 Genomic DNA. Translation: ABV74786.1. |
RefSeqi | WP_012149420.1. NC_009881.1. |
Genome annotation databases
EnsemblBacteriai | ABV74786; ABV74786; A1C_02435. |
KEGGi | rak:A1C_02435. |
Similar proteinsi
Entry informationi
Entry namei | SYE1_RICAH | |
Accessioni | A8GN11Primary (citable) accession number: A8GN11 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 24, 2009 |
Last sequence update: | November 13, 2007 | |
Last modified: | February 28, 2018 | |
This is version 64 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |