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A8GN02

- LPXB_RICAH

UniProt

A8GN02 - LPXB_RICAH

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Rickettsia akari (strain Hartford)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciRAKA293614:GI4A-450-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:A1C_02380
    OrganismiRickettsia akari (strain Hartford)
    Taxonomic identifieri293614 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000006830: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 391391Lipid-A-disaccharide synthasePRO_1000049411Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi293614.A1C_02380.

    Structurei

    3D structure databases

    ProteinModelPortaliA8GN02.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018004.
    KOiK00748.
    OMAiIARMLVN.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A8GN02-1 [UniParc]FASTAAdd to Basket

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    MTKVYFIAGE TSGDFIGGRI IQNLKSNKGV EFTGIGGKCM EEAGNFKSLF    50
    PITCINLMGF VEILPHIFNL KKLIDKTVQD IINSQADLLI TIDSPGFTYR 100
    VAKQLRKLLP KLKMIHIVAP SVWAYKDGRA VKYAKIYDCL FALLPFEPPY 150
    FTKVGLDCRY IGHPIMEQEF YSDKIALREE FKIDKNERVL CVTLGSRQGE 200
    IRKHLPVFIS SIEEIFKSCN NLKVIFTLAN PAHEAIIKPF LEDVQFHYLF 250
    SSARLKAYAV ADAALAKSGT NTLEIVASGT PMVVAYQVNL ISFFIIRLLI 300
    KIKYVTLINI IAGSEIIPEF IQFNCRASLI SNTLQELLFN SKKAYKQVIE 350
    SQKILQTLGL KSNRSPSYIA AEIIKQEFLE SKIKLLKENS T 391
    Length:391
    Mass (Da):44,141
    Last modified:November 13, 2007 - v1
    Checksum:iF0F4F9007ECECBC1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000847 Genomic DNA. Translation: ABV74777.1.
    RefSeqiYP_001493285.1. NC_009881.1.

    Genome annotation databases

    EnsemblBacteriaiABV74777; ABV74777; A1C_02380.
    GeneIDi5645791.
    KEGGirak:A1C_02380.
    PATRICi17875874. VBIRicAka50705_0488.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000847 Genomic DNA. Translation: ABV74777.1 .
    RefSeqi YP_001493285.1. NC_009881.1.

    3D structure databases

    ProteinModelPortali A8GN02.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 293614.A1C_02380.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV74777 ; ABV74777 ; A1C_02380 .
    GeneIDi 5645791.
    KEGGi rak:A1C_02380.
    PATRICi 17875874. VBIRicAka50705_0488.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018004.
    KOi K00748.
    OMAi IARMLVN.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci RAKA293614:GI4A-450-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Rickettsia akari."
      Madan A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Dasch G., Eremeeva M.
      Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Hartford.

    Entry informationi

    Entry nameiLPXB_RICAH
    AccessioniPrimary (citable) accession number: A8GN02
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3