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Protein

Phosphoribosylaminoimidazole-succinocarboxamide synthase

Gene

purC

Organism
Rickettsia akari (strain Hartford)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC)
  2. no protein annotated in this organism
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRAKA293614:GI4A-308-MONOMER.
UniPathwayiUPA00074; UER00131.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthaseUniRule annotation (EC:6.3.2.6UniRule annotation)
Alternative name(s):
SAICAR synthetaseUniRule annotation
Gene namesi
Name:purCUniRule annotation
Ordered Locus Names:A1C_01630
OrganismiRickettsia akari (strain Hartford)
Taxonomic identifieri293614 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000006830 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 236236Phosphoribosylaminoimidazole-succinocarboxamide synthasePRO_1000018769Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi293614.A1C_01630.

Structurei

3D structure databases

ProteinModelPortaliA8GML2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SAICAR synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QPR. Bacteria.
COG0152. LUCA.
HOGENOMiHOG000082629.
KOiK01923.
OMAiFNAQKRG.
OrthoDBiEOG62C9HN.

Family and domain databases

Gene3Di3.30.470.20. 1 hit.
HAMAPiMF_00137. SAICAR_synth.
InterProiIPR013816. ATP_grasp_subdomain_2.
IPR028923. SAICAR_synt/ADE2_N.
[Graphical view]
PfamiPF01259. SAICAR_synt. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8GML2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTQIYKGSS KILYSAEEDF LLIMAFSDNG ILESGEIIEV SGKGVLNNNI
60 70 80 90 100
SSFLMDKLEM IGIENHFIEK INMREQLIQY VEVFPVQVII SSVACGRFVK
110 120 130 140 150
EFGMDEGYVF DKPIIDFKVR SREFKYPIVN EYQILNFSWL TLDEIKAVKE
160 170 180 190 200
QALRIYAFLS GLFMGVGIRL VECKLEFGRV LNGEESIIML TDEISPDNCR
210 220 230
LWHIHSNEKL GFELLENKPN KAFESYQLIA DRLKEK
Length:236
Mass (Da):27,261
Last modified:November 13, 2007 - v1
Checksum:iE570DCD7F2DF970C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000847 Genomic DNA. Translation: ABV74637.1.
RefSeqiWP_012149271.1. NC_009881.1.

Genome annotation databases

EnsemblBacteriaiABV74637; ABV74637; A1C_01630.
KEGGirak:A1C_01630.
PATRICi17875559. VBIRicAka50705_0333.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000847 Genomic DNA. Translation: ABV74637.1.
RefSeqiWP_012149271.1. NC_009881.1.

3D structure databases

ProteinModelPortaliA8GML2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi293614.A1C_01630.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABV74637; ABV74637; A1C_01630.
KEGGirak:A1C_01630.
PATRICi17875559. VBIRicAka50705_0333.

Phylogenomic databases

eggNOGiENOG4107QPR. Bacteria.
COG0152. LUCA.
HOGENOMiHOG000082629.
KOiK01923.
OMAiFNAQKRG.
OrthoDBiEOG62C9HN.

Enzyme and pathway databases

UniPathwayiUPA00074; UER00131.
BioCyciRAKA293614:GI4A-308-MONOMER.

Family and domain databases

Gene3Di3.30.470.20. 1 hit.
HAMAPiMF_00137. SAICAR_synth.
InterProiIPR013816. ATP_grasp_subdomain_2.
IPR028923. SAICAR_synt/ADE2_N.
[Graphical view]
PfamiPF01259. SAICAR_synt. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Rickettsia akari."
    Madan A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Dasch G., Eremeeva M.
    Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Hartford.

Entry informationi

Entry nameiPUR7_RICAH
AccessioniPrimary (citable) accession number: A8GML2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 13, 2007
Last modified: November 11, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.