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A8GMJ8

- DEF_RICAH

UniProt

A8GMJ8 - DEF_RICAH

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Protein

Peptide deformylase

Gene

def

Organism
Rickettsia akari (strain Hartford)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Binds 1 Fe2+ ion.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi99 – 991IronUniRule annotation
Metal bindingi141 – 1411IronUniRule annotation
Active sitei142 – 1421UniRule annotation
Metal bindingi145 – 1451IronUniRule annotation

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. peptide deformylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciRAKA293614:GI4A-292-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylaseUniRule annotation (EC:3.5.1.88UniRule annotation)
Short name:
PDFUniRule annotation
Alternative name(s):
Polypeptide deformylaseUniRule annotation
Gene namesi
Name:defUniRule annotation
Ordered Locus Names:A1C_01560
OrganismiRickettsia akari (strain Hartford)
Taxonomic identifieri293614 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000006830: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 175175Peptide deformylasePRO_1000023133Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi293614.A1C_01560.

Structurei

3D structure databases

ProteinModelPortaliA8GMJ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the polypeptide deformylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0242.
HOGENOMiHOG000243509.
KOiK01462.
OMAiQQANNST.
OrthoDBiEOG664CMF.

Family and domain databases

Gene3Di3.90.45.10. 1 hit.
HAMAPiMF_00163. Pep_deformylase.
InterProiIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
PANTHERiPTHR10458. PTHR10458. 1 hit.
PfamiPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFiPIRSF004749. Pep_def. 1 hit.
PRINTSiPR01576. PDEFORMYLASE.
SUPFAMiSSF56420. SSF56420. 1 hit.
TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

Sequencei

Sequence statusi: Complete.

A8GMJ8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSILPIVTAP DDRLKQKSQP VLEFTDQTRK FMDDMLKTMY HEDGAGLAAV
60 70 80 90 100
QVGVLKRILV IDIKDHDSVE RPKDFYPLFI VNPEMIEKSE ELIKSNEGCI
110 120 130 140 150
SVPGQRIEVA RPESIKIRYL DYHGKSQELK ANDWLARVIQ HEYDHLEGKL
160 170
MIDYLSNLKR DVVLRKLKKL KNNIV
Length:175
Mass (Da):20,301
Last modified:November 13, 2007 - v1
Checksum:i224CCDA89222973E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000847 Genomic DNA. Translation: ABV74623.1.
RefSeqiYP_001493131.1. NC_009881.1.

Genome annotation databases

EnsemblBacteriaiABV74623; ABV74623; A1C_01560.
GeneIDi5645577.
KEGGirak:A1C_01560.
PATRICi17875527. VBIRicAka50705_0319.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000847 Genomic DNA. Translation: ABV74623.1 .
RefSeqi YP_001493131.1. NC_009881.1.

3D structure databases

ProteinModelPortali A8GMJ8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 293614.A1C_01560.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV74623 ; ABV74623 ; A1C_01560 .
GeneIDi 5645577.
KEGGi rak:A1C_01560.
PATRICi 17875527. VBIRicAka50705_0319.

Phylogenomic databases

eggNOGi COG0242.
HOGENOMi HOG000243509.
KOi K01462.
OMAi QQANNST.
OrthoDBi EOG664CMF.

Enzyme and pathway databases

BioCyci RAKA293614:GI4A-292-MONOMER.

Family and domain databases

Gene3Di 3.90.45.10. 1 hit.
HAMAPi MF_00163. Pep_deformylase.
InterProi IPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view ]
PANTHERi PTHR10458. PTHR10458. 1 hit.
Pfami PF01327. Pep_deformylase. 1 hit.
[Graphical view ]
PIRSFi PIRSF004749. Pep_def. 1 hit.
PRINTSi PR01576. PDEFORMYLASE.
SUPFAMi SSF56420. SSF56420. 1 hit.
TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Rickettsia akari."
    Madan A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Dasch G., Eremeeva M.
    Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Hartford.

Entry informationi

Entry nameiDEF_RICAH
AccessioniPrimary (citable) accession number: A8GMJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 13, 2007
Last modified: October 1, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3