A8GM78 (LEP_RICAH) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 38.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Signal peptidase I Short name=SPase I EC=3.4.21.89 Alternative name(s): Leader peptidase I | ||||
| Gene names |
| ||||
| Organism | Rickettsia akari (strain Hartford) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 293614 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group |
Protein attributes
| Sequence length | 266 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Catalytic activity | Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins. |
| Subcellular location | Cell inner membrane; Single-pass type II membrane protein Potential. |
| Sequence similarities | Belongs to the peptidase S26 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cell inner membrane Cell membrane Membrane |
| Domain | Transmembrane Transmembrane helix |
| Molecular function | Hydrolase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | proteolysis Inferred from electronic annotation. Source: InterPro |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | serine-type peptidase activity Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 266 | 266 | Signal peptidase I | PRO_0000316271 | |||||
Regions | |||||||||
| Topological domain | 1 – 20 | 20 | Cytoplasmic Potential | ||||||
| Transmembrane | 21 – 41 | 21 | Helical; Potential | ||||||
| Topological domain | 42 – 266 | 225 | Periplasmic Potential | ||||||
Sites | |||||||||
| Active site | 45 | 1 | By similarity | ||||||
| Active site | 108 | 1 | By similarity | ||||||
Sequences
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References
| [1] | "Complete genome sequence of Rickettsia akari." Madan A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Dasch G., Eremeeva M. Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Hartford. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000847 Genomic DNA. Translation: ABV74503.1. |
| RefSeq | YP_001493011.1. NC_009881.1. |
3D structure databases | |
| ProteinModelPortal | A8GM78. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | A8GM78. |
Protein family/group databases | |
| MEROPS | S26.001. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 5645095. |
| GenomeReviews | Gene locus A1C_00865 in contig CP000847_GR. |
| KEGG | rak:A1C_00865. |
| NMPDR | fig|293614.3.peg.161. |
| PATRIC | 17875239. VBIRicAka50705_0177. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG0681. |
| HOGENOM | HBG596607. |
| OMA | KPWIESV. |
| ProtClustDB | CLSK870751. |
Enzyme and pathway databases | |
| BioCyc | RAKA293614:A1C_00865-MONOMER. |
Family and domain databases | |
| InterPro | IPR000223. Pept_S26A_signal_pept_1. IPR019758. Pept_S26A_signal_pept_1_CS. IPR019757. Pept_S26A_signal_pept_1_Lys-AS. IPR019759. Peptidase_S24_S26. IPR015927. Peptidase_S24_S26A/B/C. IPR011056. Peptidase_S24_S26A/B/C_b-rbn. [Graphical view] |
| Gene3D | G3DSA:2.10.109.10. Pept_S24_S26_C. 2 hits. |
| KO | K03100. |
| Pfam | PF00717. Peptidase_S24. 1 hit. [Graphical view] |
| PRINTS | PR00727. LEADERPTASE. |
| SUPFAM | SSF51306. Pept_S24_S26_C. 1 hit. |
| TIGRFAMs | TIGR02227. Sigpep_I_bact. 1 hit. |
| PROSITE | PS00760. SPASE_I_2. 1 hit. PS00761. SPASE_I_3. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | LEP_RICAH | ||||||||
| Accession | Primary (citable) accession number: A8GM78 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| Peptidase families Classification of peptidase families and list of entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with