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Protein

dCTP deaminase

Gene

dcd

Organism
Rickettsia akari (strain Hartford)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the deamination of dCTP to dUTP.UniRule annotation

Catalytic activityi

dCTP + H2O = dUTP + NH3.UniRule annotation

Pathwayi: dUMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes dUMP from dCTP (dUTP route).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. dCTP deaminase (dcd)
  2. Deoxyuridine 5'-triphosphate nucleotidohydrolase (dut)
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP (dUTP route), the pathway dUMP biosynthesis and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei137Proton donor/acceptorUniRule annotation1
Binding sitei156dCTPUniRule annotation1
Binding sitei170dCTPUniRule annotation1
Binding sitei179dCTPUniRule annotation1
Binding sitei180dCTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi111 – 116dCTP bindingUniRule annotation6
Nucleotide bindingi135 – 137dCTP bindingUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandNucleotide-binding

Enzyme and pathway databases

BioCyciRAKA293614:G1GA4-95-MONOMER
UniPathwayiUPA00610; UER00665

Names & Taxonomyi

Protein namesi
Recommended name:
dCTP deaminaseUniRule annotation (EC:3.5.4.13UniRule annotation)
Alternative name(s):
Deoxycytidine triphosphate deaminaseUniRule annotation
Gene namesi
Name:dcdUniRule annotation
Ordered Locus Names:A1C_00540
OrganismiRickettsia akari (strain Hartford)
Taxonomic identifieri293614 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000006830 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000097991 – 188dCTP deaminaseAdd BLAST188

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi293614.A1C_00540

Structurei

3D structure databases

ProteinModelPortaliA8GM16
SMRiA8GM16
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dCTP deaminase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DHP Bacteria
COG0717 LUCA
HOGENOMiHOG000228600
KOiK01494
OMAiGQLCLFR
OrthoDBiPOG091H02A6

Family and domain databases

CDDicd07557 trimeric_dUTPase, 1 hit
Gene3Di2.70.40.10, 1 hit
HAMAPiMF_00146 dCTP_deaminase, 1 hit
InterProiView protein in InterPro
IPR011962 dCTP_deaminase
IPR029054 dUTPase-like
IPR036157 dUTPase-like_sf
IPR033704 dUTPase_trimeric
PfamiView protein in Pfam
PF00692 dUTPase, 1 hit
SUPFAMiSSF51283 SSF51283, 1 hit
TIGRFAMsiTIGR02274 dCTP_deam, 1 hit

Sequencei

Sequence statusi: Complete.

A8GM16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIMSDKWIK EAVINQSMIS PFAEKQVRVH NKEKIISYGL SSYGYDARVS
60 70 80 90 100
NEFKIFTNIN STTVDPKNFS EYNLVDREVD VCIIPPNSFA LGRTIEYFKI
110 120 130 140 150
PRDVLVICVG KSTYARCGII VNVTPLEPEW EGHVTLEFSN TTPLPAKIYA
160 170 180
NEGACQFLFL KSDQICDTSY ADRQGKYMKQ VGVTLPLT
Length:188
Mass (Da):21,249
Last modified:November 13, 2007 - v1
Checksum:iE0DC820FD3B5F7EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000847 Genomic DNA Translation: ABV74441.1
RefSeqiWP_012013311.1, NC_009881.1

Genome annotation databases

EnsemblBacteriaiABV74441; ABV74441; A1C_00540
KEGGirak:A1C_00540

Similar proteinsi

Entry informationi

Entry nameiDCD_RICAH
AccessioniPrimary (citable) accession number: A8GM16
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 13, 2007
Last modified: April 25, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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