A8GL77 (STHA_SERP5) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Soluble pyridine nucleotide transhydrogenase
Short name=STH
EC=1.6.1.1

Alternative name(s):
NAD(P)(+) transhydrogenase [B-specific]

Gene names

Name:	sthA
Synonyms:	udhA
Ordered Locus Names:	Spro_4774

Organism

Serratia proteamaculans (strain 568) [Complete proteome] [HAMAP]

Taxonomic identifier

399741 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Serratia

Protein attributes

Sequence length	465 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation By similarity. HAMAP MF_00247
Catalytic activity	NADPH + NAD+ = NADP+ + NADH. HAMAP MF_00247
Cofactor	Binds 1 FAD per subunit By similarity. HAMAP MF_00247
Subcellular location	Cytoplasm By similarity HAMAP MF_00247.
Sequence similarities	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	FAD Flavoprotein NAD NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NAD(P)+ transhydrogenase (B-specific) activity Inferred from electronic annotation. Source: EC flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 465	465	Soluble pyridine nucleotide transhydrogenase HAMAP MF_00247		PRO_1000059011
Regions
	Nucleotide binding	36 – 45	10	FAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	A8GL77 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: 333239320BC80F3F	FASTA	465	51,218
	10 20 30 40 50 60 MQQHYQFDAI VIGSGPGGEG AAMGLVKQGA RVAVIERYNN VGGGCTHWGT IPSKALRHAV 70 80 90 100 110 120 SRIIEFNQNP LYNNSRTLSA TFPDILRHAD NVINQQTRMR QGFYERNQCK LFAGDARFID 130 140 150 160 170 180 ANTVSVSYMD GTQDTIRADH IVIACGSRPY NPSSVDFNHP RIYNSDSILE LNHEPRHVII 190 200 210 220 230 240 YGAGVIGCEY ASIFRGLNVK VDLINTRDRL LAFLDQEMSD SLSYHFWNNG VVIRHNEEFE 250 260 270 280 290 300 KIEGTDDGVI VHLKSGKKVK ADCLLYANGR TGNTDSLGLE NVGLESDSRG LLKVNSMYQT 310 320 330 340 350 360 ALSHIYAVGD VIGYPSLASA AYDQGRIAAQ AIASGEASGH LIEDIPTGIY TIPEISSVGK 370 380 390 400 410 420 TEQELTAMKV PYEVGRAQFK HLARAQIAGM NVGSLKILFH RDTLQILGIH CFGERAAEII 430 440 450 460 HIGQAIMEQK GEGNTIEYFV NTTFNYPTMA EAYRVAALNG LNRLF

References

[1]

"Complete sequence of chromosome of Serratia proteamaculans 568." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E. , Taghavi S., Newman L., Vangronsveld J., van der Lelie D., Richardson P. Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 568.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000826 Genomic DNA. Translation: ABV43867.1.
RefSeq	YP_001480995.1. NC_009832.1.
3D structure databases
ProteinModelPortal	A8GL77.
ModBase	Search...
Protein-protein interaction databases
STRING	A8GL77.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5604663.
GenomeReviews	Gene locus Spro_4774 in contig CP000826_GR.
KEGG	spe:Spro_4774.
PATRIC	32422388. VBISerPro44537_4827.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1249.
HOGENOM	HBG515043.
OMA	GEGNTIE.
ProtClustDB	PRK05249.
Enzyme and pathway databases
BioCyc	SPRO399741:SPRO_4774-MONOMER.
Family and domain databases
HAMAP	MF_00247. SthA. [Tree]
InterPro	IPR016156. FAD/NAD-linked_Rdtase_dimer. IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR004099. Pyr_nucl-diS_OxRdtase_dimer. IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD. IPR001327. Pyr_OxRdtase_NAD-bd_dom. IPR022962. STH. [Graphical view]
Gene3D	G3DSA:3.30.390.30. Pyr_redox_dim. 1 hit.
KO	K00322.
Pfam	PF00070. Pyr_redox. 1 hit. PF07992. Pyr_redox_2. 1 hit. PF02852. Pyr_redox_dim. 1 hit. [Graphical view]
PRINTS	PR00368. FADPNR.
SUPFAM	SSF55424. FAD/NAD-linked_reductase_dimer. 1 hit.
ProtoNet	Search...

Entry information

Entry name

STHA_SERP5

Accession

Primary (citable) accession number: A8GL77

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	November 13, 2007
Last modified:	January 25, 2012
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program