Reviewed, UniProtKB/Swiss-Prot A8GL77 (STHA_SERP5)

Names and origin

Protein names

Recommended name:
    Soluble pyridine nucleotide transhydrogenase
      Short name=STH
    EC=1.6.1.1
Alternative name(s):
    NAD(P)(+) transhydrogenase [B-specific]

Gene names

Name:	sthA
Synonyms:	udhA
Ordered Locus Names:	Spro_4774

Organism

Serratia proteamaculans (strain 568) [Complete proteome] [HAMAP]

Taxonomic identifier

399741 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Serratia

Protein attributes

Sequence length	465 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation By similarity.
Catalytic activity	NADPH + NAD+ = NADP+ + NADH. HAMAP MF_00247
Cofactor	Binds 1 FAD per subunit By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	FAD Flavoprotein NAD NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	NADP metabolic process Inferred from electronic annotation. Source: HAMAP cell redox homeostasis Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro NAD(P)+ transhydrogenase (B-specific) activity Inferred from electronic annotation. Source: HAMAP electron carrier activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 465	465	Soluble pyridine nucleotide transhydrogenase HAMAP MF_00247		PRO_1000059011
Regions
	Nucleotide binding	36 – 45	10	FAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	A8GL77-1 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: 333239320BC80F3F	FASTA	465	51,218
	10 20 30 40 50 60 MQQHYQFDAI VIGSGPGGEG AAMGLVKQGA RVAVIERYNN VGGGCTHWGT IPSKALRHAV 70 80 90 100 110 120 SRIIEFNQNP LYNNSRTLSA TFPDILRHAD NVINQQTRMR QGFYERNQCK LFAGDARFID 130 140 150 160 170 180 ANTVSVSYMD GTQDTIRADH IVIACGSRPY NPSSVDFNHP RIYNSDSILE LNHEPRHVII 190 200 210 220 230 240 YGAGVIGCEY ASIFRGLNVK VDLINTRDRL LAFLDQEMSD SLSYHFWNNG VVIRHNEEFE 250 260 270 280 290 300 KIEGTDDGVI VHLKSGKKVK ADCLLYANGR TGNTDSLGLE NVGLESDSRG LLKVNSMYQT 310 320 330 340 350 360 ALSHIYAVGD VIGYPSLASA AYDQGRIAAQ AIASGEASGH LIEDIPTGIY TIPEISSVGK 370 380 390 400 410 420 TEQELTAMKV PYEVGRAQFK HLARAQIAGM NVGSLKILFH RDTLQILGIH CFGERAAEII 430 440 450 460 HIGQAIMEQK GEGNTIEYFV NTTFNYPTMA EAYRVAALNG LNRLF

References

[1]

"Complete sequence of chromosome of Serratia proteamaculans 568." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E. , Taghavi S., Newman L., Vangronsveld J., van der Lelie D., Richardson P. Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000826 Genomic DNA. Translation: ABV43867.1.
RefSeq	YP_001480995.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A8GL77.
Genome annotation databases
GeneID	5604663.
GenomeReviews	Gene locus Spro_4774 in contig CP000826_GR.
KEGG	spe:Spro_4774.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	GEGNTIE.
Family and domain databases
HAMAP	MF_00247. [Tree]
InterPro	IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR000815. Hg_reductase. IPR004099. Pyr_nucl-diS_OxRdtase_dimer. IPR001327. Pyr_OxRdtase_NAD_bd. [Graphical view]
Gene3D	G3DSA:3.30.390.30. Pyr_redox_dim. 1 hit.
Pfam	PF00070. Pyr_redox. 1 hit. PF07992. Pyr_redox_2. 1 hit. PF02852. Pyr_redox_dim. 1 hit. [Graphical view]
PRINTS	PR00368. FADPNR. PR00945. HGRDTASE.
ProDom	PD000139. FAD_pyr_redox. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

STHA_SERP5

Accession

Primary (citable) accession number: A8GL77

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	November 13, 2007
Last modified:	November 3, 2009
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)