A8GKW1 (IOLG_SERP5) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inositol 2-dehydrogenase
EC=1.1.1.18

Alternative name(s):
Myo-inositol 2-dehydrogenase
Short name=MI 2-dehydrogenase

Gene names

Name:	iolG
Ordered Locus Names:	Spro_4658

Organism

Serratia proteamaculans (strain 568) [Complete proteome] [HAMAP]

Taxonomic identifier

399741 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Serratia

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose) By similarity. HAMAP MF_01671
Catalytic activity	Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP MF_01671
Subunit structure	Homotetramer By similarity. HAMAP MF_01671
Sequence similarities	Belongs to the gfo/idh/mocA family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	inositol catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 337	337	Inositol 2-dehydrogenase HAMAP MF_01671		PRO_0000352596

Sequences

	Sequence		Length	Mass (Da)
	A8GKW1 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: 0C7E745529ED4C3F	FASTA	337	36,704
	10 20 30 40 50 60 MTLNIGVIGT GAIGRDHIRR CSKVLQGSRI VAVNDINRDN AAKVVSDLKL DAKVYDNGHD 70 80 90 100 110 120 LVKAADVQAV LVTSWGPSHE EFVLAAIAAG KPVFCEKPLA VTAQGCKNIV EAEAKHGKRL 130 140 150 160 170 180 VQVGFMRPYD QGYRALKQVL TSGQIGEPLM LHCAHRNPTV GEAYTTDMAI TDTLIHEIDV 190 200 210 220 230 240 LRWLLDDDYV SVQVVFPRKS AKAFPHLKDP QIVLFETAKG TRIDVEIFVN CQYGYDIQCE 250 260 270 280 290 300 VVGETGIAKL PEPSSVQMRS GAKLSTEILT DWKDRFIDAY DVELQGFIND VLAGKLTGPS 310 320 330 AWDGYAAAVT ADACVAAQLS GEIVPVTLPP RPAFYNK

References

[1]

"Complete sequence of chromosome of Serratia proteamaculans 568." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E. , Taghavi S., Newman L., Vangronsveld J., van der Lelie D., Richardson P. Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 568.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000826 Genomic DNA. Translation: ABV43751.1.
RefSeq	YP_001480879.1. NC_009832.1.
3D structure databases
ProteinModelPortal	A8GKW1.
ModBase	Search...
Protein-protein interaction databases
STRING	A8GKW1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5602910.
GenomeReviews	Gene locus Spro_4658 in contig CP000826_GR.
KEGG	spe:Spro_4658.
PATRIC	32422144. VBISerPro44537_4712.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0673.
HOGENOM	HBG612336.
OMA	HINRITN.
ProtClustDB	CLSK2785235.
Enzyme and pathway databases
BioCyc	SPRO399741:SPRO_4658-MONOMER.
Family and domain databases
HAMAP	MF_01671. IolG. [Tree]
InterPro	IPR023794. MI/DCI_dehydrogenase. IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. IPR004104. OxRdtase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00010.
PANTHER	PTHR22604:SF7. PTHR22604:SF7. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. PF02894. GFO_IDH_MocA_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLG_SERP5

Accession

Primary (citable) accession number: A8GKW1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 14, 2008
Last sequence update:	November 13, 2007
Last modified:	January 25, 2012
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program