Reviewed, UniProtKB/Swiss-Prot A8GKW1 (IOLG_SERP5)

Names and origin

Protein names

Recommended name:
    Inositol 2-dehydrogenase
    EC=1.1.1.18
Alternative name(s):
    Myo-inositol 2-dehydrogenase
      Short name=MI 2-dehydrogenase

Gene names

Name:	iolG
Ordered Locus Names:	Spro_4658

Organism

Serratia proteamaculans (strain 568) [Complete proteome] [HAMAP]

Taxonomic identifier

399741 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Serratia

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose) By similarity.
Catalytic activity	Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP MF_01671
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the gfo/idh/mocA family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	inositol catabolic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro electron carrier activity Inferred from electronic annotation. Source: InterPro inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 337	337	Inositol 2-dehydrogenase HAMAP MF_01671		PRO_0000352596

Sequences

	Sequence		Length	Mass (Da)
	A8GKW1-1 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: 0C7E745529ED4C3F	FASTA	337	36,704
	10 20 30 40 50 60 MTLNIGVIGT GAIGRDHIRR CSKVLQGSRI VAVNDINRDN AAKVVSDLKL DAKVYDNGHD 70 80 90 100 110 120 LVKAADVQAV LVTSWGPSHE EFVLAAIAAG KPVFCEKPLA VTAQGCKNIV EAEAKHGKRL 130 140 150 160 170 180 VQVGFMRPYD QGYRALKQVL TSGQIGEPLM LHCAHRNPTV GEAYTTDMAI TDTLIHEIDV 190 200 210 220 230 240 LRWLLDDDYV SVQVVFPRKS AKAFPHLKDP QIVLFETAKG TRIDVEIFVN CQYGYDIQCE 250 260 270 280 290 300 VVGETGIAKL PEPSSVQMRS GAKLSTEILT DWKDRFIDAY DVELQGFIND VLAGKLTGPS 310 320 330 AWDGYAAAVT ADACVAAQLS GEIVPVTLPP RPAFYNK

References

[1]

"Complete sequence of chromosome of Serratia proteamaculans 568." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E. , Taghavi S., Newman L., Vangronsveld J., van der Lelie D., Richardson P. Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000826 Genomic DNA. Translation: ABV43751.1.
RefSeq	YP_001480879.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A8GKW1.
Genome annotation databases
GeneID	5602910.
GenomeReviews	Gene locus Spro_4658 in contig CP000826_GR.
KEGG	spe:Spro_4658.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	DWKDRFI.
Family and domain databases
HAMAP	MF_01671. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. IPR004104. OxRdtase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. PF02894. GFO_IDH_MocA_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLG_SERP5

Accession

Primary (citable) accession number: A8GKW1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 14, 2008
Last sequence update:	November 13, 2007
Last modified:	November 3, 2009
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)