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Protein

Inosose dehydratase

Gene

iolE

Organism
Serratia proteamaculans (strain 568)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the dehydration of inosose (2-keto-myo-inositol, 2KMI or 2,4,6/3,5-pentahydroxycyclohexanone) to 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi-inositol).UniRule annotation

Catalytic activityi

2,4,6/3,5-pentahydroxycyclohexanone = 3,5/4-trihydroxycyclohexa-1,2-dione + H2O.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • glutathioneUniRule annotation
  • Co2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
LigandCobalt, Manganese

Names & Taxonomyi

Protein namesi
Recommended name:
Inosose dehydrataseUniRule annotation (EC:4.2.1.44UniRule annotation)
Alternative name(s):
2-keto-myo-inositol dehydrataseUniRule annotation
Short name:
2KMI dehydrataseUniRule annotation
Gene namesi
Name:iolEUniRule annotation
Ordered Locus Names:Spro_4656
OrganismiSerratia proteamaculans (strain 568)
Taxonomic identifieri399741 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeSerratia
Proteomesi
  • UP000007074 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003523801 – 298Inosose dehydrataseAdd BLAST298

Interactioni

Protein-protein interaction databases

STRINGi399741.Spro_4656

Structurei

3D structure databases

ProteinModelPortaliA8GKV9
SMRiA8GKV9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IolE/MocC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJK Bacteria
COG1082 LUCA
HOGENOMiHOG000239720
KOiK03335
OMAiHDYSGWI
OrthoDBiPOG091H0BG2

Family and domain databases

HAMAPiMF_01672 IolE, 1 hit
InterProiView protein in InterPro
IPR023952 IolE
IPR030823 IolE/MocC
IPR036237 Xyl_isomerase-like_sf
IPR013022 Xyl_isomerase-like_TIM-brl
PfamiView protein in Pfam
PF01261 AP_endonuc_2, 1 hit
SUPFAMiSSF51658 SSF51658, 1 hit
TIGRFAMsiTIGR04379 myo_inos_iolE, 1 hit

Sequencei

Sequence statusi: Complete.

A8GKV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKDNVKLAI APIGWTNDDM PDLGKENTFQ QCVSEMALAG FTGSEVGSKY
60 70 80 90 100
PRDPAVLKPM LDIRGIQICN AWFSTFFADG LKEKTIDEFI NHMNFLHAMG
110 120 130 140 150
AKVIGCSEQS KSIQGTTKGV FEEKPYFSDE EWQRVADGYN ELADIAKGKG
160 170 180 190 200
MQVCLHHHMG TGIQTTAEID RYMSMVNDDV YLLFDTGHAY YSEGSQQAMM
210 220 230 240 250
AILEKYLPRI NHVHLKDVRD EVVAEVKANK LSFLDGVKKG TFTVPGDGVI
260 270 280 290
DFRPVFKLLD ERGYKGWMVV EAEQDPALAN PFEYAVKARR YIKETAGI
Length:298
Mass (Da):33,428
Last modified:November 13, 2007 - v1
Checksum:iAFD4C8310F237860
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000826 Genomic DNA Translation: ABV43749.1
RefSeqiWP_012147331.1, NC_009832.1

Genome annotation databases

EnsemblBacteriaiABV43749; ABV43749; Spro_4656
KEGGispe:Spro_4656

Similar proteinsi

Entry informationi

Entry nameiIOLE_SERP5
AccessioniPrimary (citable) accession number: A8GKV9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: November 13, 2007
Last modified: March 28, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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