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Protein

HTH-type transcriptional regulator MalT

Gene

malT

Organism
Serratia proteamaculans (strain 568)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides. Binds and recognizes a DNA motif (called the malT box): 5'-GGA[TG]GA-3'.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi39 – 468ATPUniRule annotation
DNA bindingi856 – 87520H-T-H motifUniRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Carbohydrate metabolism, Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPRO399741:GI55-4730-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator MalTUniRule annotation
Alternative name(s):
ATP-dependent transcriptional activator MalTUniRule annotation
Gene namesi
Name:malTUniRule annotation
Ordered Locus Names:Spro_4637
OrganismiSerratia proteamaculans (strain 568)
Taxonomic identifieri399741 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSerratia
Proteomesi
  • UP000007074 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 904904HTH-type transcriptional regulator MalTPRO_1000085778Add
BLAST

Interactioni

Subunit structurei

Monomer in solution but oligomerizes to an active state in the presence of the positive effectors ATP and maltotriose.UniRule annotation

Protein-protein interaction databases

STRINGi399741.Spro_4637.

Structurei

3D structure databases

ProteinModelPortaliA8GKU0.
SMRiA8GKU0. Positions 449-806.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini832 – 89766HTH luxR-typeUniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH luxR-type DNA-binding domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG41061ZR. Bacteria.
COG2909. LUCA.
HOGENOMiHOG000218261.
KOiK03556.
OMAiSDWVSNA.
OrthoDBiEOG69GZGV.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.25.40.10. 1 hit.
HAMAPiMF_01247. HTH_type_MalT.
InterProiIPR027417. P-loop_NTPase.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR011990. TPR-like_helical_dom.
IPR023768. Tscrpt_reg_HTH_MalT.
IPR000792. Tscrpt_reg_LuxR_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00196. GerE. 1 hit.
[Graphical view]
PRINTSiPR00038. HTHLUXR.
SMARTiSM00421. HTH_LUXR. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF48452. SSF48452. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00622. HTH_LUXR_1. 1 hit.
PS50043. HTH_LUXR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8GKU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLIPSKLSRP VRLQNTVIRD RLLAKLASTA NYRLTLVNCP AGYGKTTLVA
60 70 80 90 100
QWAAGKSDLG WYSLDESDNQ PERFASYLIA ALQLASGGHC VKSEALSQKH
110 120 130 140 150
QYASLSALFA QLFIELSDWH QPLYLVIDDY HLITNDVIHE AMRFFLRHQP
160 170 180 190 200
ENLTLILLSR TLPPLGIANL RVRDQLLEMG TQQLAFTHQE AKQFFDCRLV
210 220 230 240 250
SPMESQDSSR LCDEVEGWAT ALQLIALSAR QSNSSAQQSA KRLAGLNASH
260 270 280 290 300
LSDYLVDEVL DHVDAEARAF LLRCSVLRSM NDALIVRLTG EDNGQQRLEE
310 320 330 340 350
LERQGLFIHR MDDSGEWFCF HPLFATFLRQ RCQWELALEL PGLHRAAAEG
360 370 380 390 400
WLALGYPAEA IHHALAASDV SMLRDILLQH AWSLFHHSEL ALLEECLNAL
410 420 430 440 450
PYERLIQNPK LALLQAWLAQ SQHRYSEVNT LLERAEQAMR DQKIEVDRTL
460 470 480 490 500
EAEFDALRAQ VAINAGKPEE AERLATEALK FLPLSSYYSR IVATSVTGEV
510 520 530 540 550
HHCKGELARA LPMMQQTEQM ARRHQAYHYA LWALLQQSEI LIAQGFLQAA
560 570 580 590 600
FETQDKAFEL VREQHLEQLP MHEFLLRIRS QILWSWSRLD EAEDAAREGL
610 620 630 640 650
KILANYQPQQ QLQCIAMLAK CSLARGDLDN ANAHMQRCEV LLHGTQYHRD
660 670 680 690 700
WLTNADKPRV IHWQMTGDTT AAAQWLRQTE KPGMADNHFM QGQWRNIARV
710 720 730 740 750
QIMLGQYEEA EVVLDELNEN ARRLRLVSDL NRNLLLSNQL YWQMERKSDA
760 770 780 790 800
QKVLMEALSL ASRTGFISHF VIEGEAMAQQ LRQLIQLNTL PELENHRAQR
810 820 830 840 850
ILRDINQHHR HKFAHFDENF VDKLLTHPQV PELIRTSPLT QREWQVLGLI
860 870 880 890 900
YSGYSNDQIA GELAVAATTI KTHIRNLYQK LGVAHRQEAV QQAQQLLKMM

GYGA
Length:904
Mass (Da):103,392
Last modified:November 13, 2007 - v1
Checksum:i1E0AC421AE3BB3EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000826 Genomic DNA. Translation: ABV43730.1.
RefSeqiWP_012147312.1. NC_009832.1.

Genome annotation databases

EnsemblBacteriaiABV43730; ABV43730; Spro_4637.
KEGGispe:Spro_4637.
PATRICi32422102. VBISerPro44537_4691.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000826 Genomic DNA. Translation: ABV43730.1.
RefSeqiWP_012147312.1. NC_009832.1.

3D structure databases

ProteinModelPortaliA8GKU0.
SMRiA8GKU0. Positions 449-806.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi399741.Spro_4637.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABV43730; ABV43730; Spro_4637.
KEGGispe:Spro_4637.
PATRICi32422102. VBISerPro44537_4691.

Phylogenomic databases

eggNOGiENOG41061ZR. Bacteria.
COG2909. LUCA.
HOGENOMiHOG000218261.
KOiK03556.
OMAiSDWVSNA.
OrthoDBiEOG69GZGV.

Enzyme and pathway databases

BioCyciSPRO399741:GI55-4730-MONOMER.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.25.40.10. 1 hit.
HAMAPiMF_01247. HTH_type_MalT.
InterProiIPR027417. P-loop_NTPase.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR011990. TPR-like_helical_dom.
IPR023768. Tscrpt_reg_HTH_MalT.
IPR000792. Tscrpt_reg_LuxR_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00196. GerE. 1 hit.
[Graphical view]
PRINTSiPR00038. HTHLUXR.
SMARTiSM00421. HTH_LUXR. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF48452. SSF48452. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00622. HTH_LUXR_1. 1 hit.
PS50043. HTH_LUXR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 568.

Entry informationi

Entry nameiMALT_SERP5
AccessioniPrimary (citable) accession number: A8GKU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 13, 2007
Last modified: December 9, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.