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Protein

Chorismate pyruvate-lyase

Gene

ubiC

Organism
Serratia proteamaculans (strain 568)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.UniRule annotation

Catalytic activityi

Chorismate = 4-hydroxybenzoate + pyruvate.UniRule annotation

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36Substrate; via amide nitrogenUniRule annotation1
Binding sitei78SubstrateUniRule annotation1
Binding sitei116Substrate; via amide nitrogenUniRule annotation1
Binding sitei157SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processUbiquinone biosynthesis
LigandPyruvate

Enzyme and pathway databases

UniPathwayiUPA00232

Names & Taxonomyi

Protein namesi
Recommended name:
Chorismate pyruvate-lyaseUniRule annotation (EC:4.1.3.40UniRule annotation)
Short name:
CLUniRule annotation
Short name:
CPLUniRule annotation
Gene namesi
Name:ubiCUniRule annotation
Ordered Locus Names:Spro_4464
OrganismiSerratia proteamaculans (strain 568)
Taxonomic identifieri399741 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeSerratia
Proteomesi
  • UP000007074 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000697471 – 174Chorismate pyruvate-lyaseAdd BLAST174

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi399741.Spro_4464

Structurei

3D structure databases

ProteinModelPortaliA8GKB8
SMRiA8GKB8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UbiC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105VEI Bacteria
COG3161 LUCA
HOGENOMiHOG000137785
KOiK03181
OMAiELWGRRS
OrthoDBiPOG091H047C

Family and domain databases

Gene3Di3.40.1410.10, 1 hit
HAMAPiMF_01632 UbiC, 1 hit
InterProiView protein in InterPro
IPR007440 Chorismate--pyruvate_lyase
IPR028978 Chorismate_lyase_/UTRA_dom_sf
PANTHERiPTHR38683 PTHR38683, 1 hit
PfamiView protein in Pfam
PF04345 Chor_lyase, 1 hit
SUPFAMiSSF64288 SSF64288, 1 hit

Sequencei

Sequence statusi: Complete.

A8GKB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGNRDSILP PLEWLSAQHP PAPAAVSDWL MEPGSMTRRF ERHCGRVHVE
60 70 80 90 100
PQRECFVTRD QLGEEAEHLP DSPRYWLREV VLLGDNQPWL LGRTVIPLET
110 120 130 140 150
LTGPDLALVD LGTLPLGRYL FSSDELTRDY IHIGRQDALW ARRSRLRLAG
160 170
KPLLLTELFL PASPLYATGS SVPE
Length:174
Mass (Da):19,656
Last modified:November 13, 2007 - v1
Checksum:iF0D1FEDF0260CE8D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000826 Genomic DNA Translation: ABV43558.1
RefSeqiWP_012147158.1, NC_009832.1

Genome annotation databases

EnsemblBacteriaiABV43558; ABV43558; Spro_4464
KEGGispe:Spro_4464

Similar proteinsi

Entry informationi

Entry nameiUBIC_SERP5
AccessioniPrimary (citable) accession number: A8GKB8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: March 28, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health