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Protein

Glycerol-3-phosphate acyltransferase

Gene

plsB

Organism
Serratia proteamaculans (strain 568)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate.UniRule annotation

Pathwayi: CDP-diacylglycerol biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glycerol-3-phosphate acyltransferase (plsB)
  2. no protein annotated in this organism
  3. Phosphatidate cytidylyltransferase (Spro_3784)
This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciSPRO399741:GI55-4549-MONOMER.
UniPathwayiUPA00557; UER00612.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate acyltransferaseUniRule annotation (EC:2.3.1.15UniRule annotation)
Short name:
GPATUniRule annotation
Gene namesi
Name:plsBUniRule annotation
Ordered Locus Names:Spro_4462
OrganismiSerratia proteamaculans (strain 568)
Taxonomic identifieri399741 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSerratia
Proteomesi
  • UP000007074 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 821821Glycerol-3-phosphate acyltransferasePRO_1000060778Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi399741.Spro_4462.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi304 – 3096HXXXXD motif

Domaini

The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.UniRule annotation

Sequence similaritiesi

Belongs to the GPAT/DAPAT family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E55. Bacteria.
COG2937. LUCA.
HOGENOMiHOG000218231.
KOiK00631.
OMAiEVIYVPC.
OrthoDBiPOG091H06BX.

Family and domain databases

HAMAPiMF_00393. Glyc3P_acyltrans. 1 hit.
InterProiIPR022284. GPAT/DHAPAT.
IPR028354. GPAT_PlsB.
IPR002123. Plipid/glycerol_acylTrfase.
[Graphical view]
PANTHERiPTHR12563. PTHR12563. 2 hits.
PfamiPF01553. Acyltransferase. 1 hit.
[Graphical view]
PIRSFiPIRSF500064. GPAT. 1 hit.
PIRSF000437. GPAT_DHAPAT. 1 hit.
SMARTiSM00563. PlsC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03703. plsB. 1 hit.

Sequencei

Sequence statusi: Complete.

A8GKB6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGWRKIYYK LLNLPLKLLV RSKVIPSDPV TELGLDPSRP ILYVLPYNSK
60 70 80 90 100
ADLLTLRTQC LAQDLPDPLN PLEIDGTVLP SHVFIHDGPR VFRYYTPKEE
110 120 130 140 150
SVKLFHDYLD LHRSNPDLDI QMLPVSVMFG RSPGREGHGT PHLRLLNGVQ
160 170 180 190 200
KFFAVLWLGR DSFVRFSNTV SLRRMATEHG TDKIIAQKLA RVARMHFSRQ
210 220 230 240 250
RLAAVGPSLP ARQDLFNKLL ASKAIEKAVE DEARSKKISH EKAQQNAIAL
260 270 280 290 300
MEEIAADFSY ETVRLSDRVL SWTWNRLYQG INVTNAERVR QLAQDGHEIV
310 320 330 340 350
YVPCHRSHMD YLLLSYVLYH QGLVPPHIAA GINLNFWPAG PIFRRLGAFF
360 370 380 390 400
IRRTFKGNKL YSTVFREYLG ELFTRGYSVE YFVEGGRSRT GRLLEPKTGT
410 420 430 440 450
LSMTIQAMLR GGSRPITLVP IYIGYEHVME VGTYAKELRG ATKEKESLLQ
460 470 480 490 500
MLRGLRKLRN LGQGYVNFGD PLPLTAYLNQ NVPQWRESID PIEAQRPSWL
510 520 530 540 550
TPTVNDLAAK IMVRINNAAA ANAMNLCSTA LLASRQRSLT REQLLEQLEC
560 570 580 590 600
YLQLMRNVPY AGDVTVPTQT PDELLDHALN MNKFEVEKDN IGDIIILPRE
610 620 630 640 650
QAVLMTYYRN NIHHLLVLPS LIATIVMHHR RVSRAELLRQ IGLIYPMLKA
660 670 680 690 700
ELFLHNDKEQ LPEVLRPLID EMIRQQLICD KGDDLVLNPA RIRPLQLLAA
710 720 730 740 750
GVRETLQRYA ITMSILSANP SINRGALEKE SRIMAQRLSV LHGINAPEFF
760 770 780 790 800
DKAVFSTLVA TLRAEGYIND IGDAVREHTM EVYNMLSDLI TPEIKLTIES
810 820
VSMPAETNAL PETVAAEEKE D
Length:821
Mass (Da):93,297
Last modified:November 13, 2007 - v1
Checksum:i09B53B7CF8287DCA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000826 Genomic DNA. Translation: ABV43556.1.
RefSeqiWP_012147156.1. NC_009832.1.

Genome annotation databases

EnsemblBacteriaiABV43556; ABV43556; Spro_4462.
KEGGispe:Spro_4462.
PATRICi32421740. VBISerPro44537_4516.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000826 Genomic DNA. Translation: ABV43556.1.
RefSeqiWP_012147156.1. NC_009832.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi399741.Spro_4462.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABV43556; ABV43556; Spro_4462.
KEGGispe:Spro_4462.
PATRICi32421740. VBISerPro44537_4516.

Phylogenomic databases

eggNOGiENOG4105E55. Bacteria.
COG2937. LUCA.
HOGENOMiHOG000218231.
KOiK00631.
OMAiEVIYVPC.
OrthoDBiPOG091H06BX.

Enzyme and pathway databases

UniPathwayiUPA00557; UER00612.
BioCyciSPRO399741:GI55-4549-MONOMER.

Family and domain databases

HAMAPiMF_00393. Glyc3P_acyltrans. 1 hit.
InterProiIPR022284. GPAT/DHAPAT.
IPR028354. GPAT_PlsB.
IPR002123. Plipid/glycerol_acylTrfase.
[Graphical view]
PANTHERiPTHR12563. PTHR12563. 2 hits.
PfamiPF01553. Acyltransferase. 1 hit.
[Graphical view]
PIRSFiPIRSF500064. GPAT. 1 hit.
PIRSF000437. GPAT_DHAPAT. 1 hit.
SMARTiSM00563. PlsC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03703. plsB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPLSB_SERP5
AccessioniPrimary (citable) accession number: A8GKB6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: September 7, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.