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Protein

G/U mismatch-specific DNA glycosylase

Gene

mug

Organism
Serratia proteamaculans (strain 568)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base. The complementary strand guanine functions in substrate recognition. Required for DNA damage lesion repair in stationary-phase cells.UniRule annotation

Catalytic activityi

Specifically hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Hydrolase
Biological processDNA damage, DNA excision, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
G/U mismatch-specific DNA glycosylaseUniRule annotation (EC:3.2.2.28UniRule annotation)
Alternative name(s):
Double-strand-specific uracil glycosylaseUniRule annotation
Mismatch-specific uracil DNA-glycosylaseUniRule annotation
Short name:
MUGUniRule annotation
Gene namesi
Name:mugUniRule annotation
Ordered Locus Names:Spro_4301
OrganismiSerratia proteamaculans (strain 568)
Taxonomic identifieri399741 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeSerratia
Proteomesi

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000707951 – 162G/U mismatch-specific DNA glycosylaseAdd BLAST162

Interactioni

Subunit structurei

Binds DNA as a monomer.UniRule annotation

Protein-protein interaction databases

STRINGi399741.Spro_4301

Structurei

3D structure databases

ProteinModelPortaliA8GJV5
SMRiA8GJV5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the uracil-DNA glycosylase (UDG) superfamily. TDG/mug family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108VCA Bacteria
COG3663 LUCA
HOGENOMiHOG000264684
KOiK03649
OMAiTGHHFAR
OrthoDBiPOG091H0DTQ

Family and domain databases

CDDicd10028 UDG_F2_MUG, 1 hit
Gene3Di3.40.470.10, 1 hit
HAMAPiMF_01956 MUG, 1 hit
InterProiView protein in InterPro
IPR015637 MUG/TDG
IPR023502 MUG_bact
IPR005122 Uracil-DNA_glycosylase-like
IPR036895 Uracil-DNA_glycosylase-like_sf
PANTHERiPTHR12159 PTHR12159, 1 hit
PfamiView protein in Pfam
PF03167 UDG, 1 hit
SUPFAMiSSF52141 SSF52141, 1 hit

Sequencei

Sequence statusi: Complete.

A8GJV5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELLAPNLRV VFCGINPGLS SAHQGYPFAN GSNRFWKVVH QAGFTDTQLA
60 70 80 90 100
PEQWQQLQDT GCGITALVAR PTVAASEVTR DELLSGGEAL KEKILRYQPR
110 120 130 140 150
ALAILGKQAF SSAFGVKNAA WGRQEMTIGK TEVWVLPNPS GLNRATLEQL
160
TESYRELFLA LK
Length:162
Mass (Da):17,772
Last modified:November 13, 2007 - v1
Checksum:i91B1C4E05D5F032C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000826 Genomic DNA Translation: ABV43395.1
RefSeqiWP_012146998.1, NC_009832.1

Genome annotation databases

EnsemblBacteriaiABV43395; ABV43395; Spro_4301
KEGGispe:Spro_4301

Entry informationi

Entry nameiMUG_SERP5
AccessioniPrimary (citable) accession number: A8GJV5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: March 28, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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