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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Serratia proteamaculans (strain 568)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAntibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Ordered Locus Names:Spro_4294
OrganismiSerratia proteamaculans (strain 568)
Taxonomic identifieri399741 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeSerratia
Proteomesi
  • UP000007074 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 26HelicalUniRule annotationAdd BLAST21
Transmembranei45 – 65HelicalUniRule annotationAdd BLAST21
Transmembranei94 – 114HelicalUniRule annotationAdd BLAST21
Transmembranei117 – 137HelicalUniRule annotationAdd BLAST21
Transmembranei155 – 174HelicalUniRule annotationAdd BLAST20
Transmembranei191 – 211HelicalUniRule annotationAdd BLAST21
Transmembranei223 – 243HelicalUniRule annotationAdd BLAST21
Transmembranei253 – 273HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000628111 – 274Undecaprenyl-diphosphataseAdd BLAST274

Interactioni

Protein-protein interaction databases

STRINGi399741.Spro_4294

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DWR Bacteria
COG1968 LUCA
HOGENOMiHOG000218356
KOiK06153
OMAiPDARMGW
OrthoDBiPOG091H00ZR

Family and domain databases

HAMAPiMF_01006 Undec_diphosphatase, 1 hit
InterProiView protein in InterPro
IPR003824 UppP
PANTHERiPTHR30622 PTHR30622, 1 hit
PfamiView protein in Pfam
PF02673 BacA, 1 hit
TIGRFAMsiTIGR00753 undec_PP_bacA, 1 hit

Sequencei

Sequence statusi: Complete.

A8GJU8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADMHSLFIA FVLGVVEGLT EFLPVSSTGH MIIVGEWLGF TGDKAKTFEV
60 70 80 90 100
IIQLGSILAV VVMFWRRLFG LIGIHFGGKP VEHEGKTTGH LKLGHILLAM
110 120 130 140 150
IPAVVLGLLF HDVIKSLFAP KNVMYALVVG GFLLLAAEWL KPKKPSAEGL
160 170 180 190 200
DDITYRQAFM IGCFQCLALW PGFSRSGSTI AGGMLVGVNR YAAAEFSFIL
210 220 230 240 250
AVPMMIGASG LDLYKSLHFL TMGDLPMFAV GFATAFVVAL IAIKTFLTLI
260 270
KRISFVPFAI YRFIVAGVVY MVFM
Length:274
Mass (Da):29,847
Last modified:November 13, 2007 - v1
Checksum:i041BA057C8D87605
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000826 Genomic DNA Translation: ABV43388.1
RefSeqiWP_012146993.1, NC_009832.1

Genome annotation databases

EnsemblBacteriaiABV43388; ABV43388; Spro_4294
KEGGispe:Spro_4294

Similar proteinsi

Entry informationi

Entry nameiUPPP_SERP5
AccessioniPrimary (citable) accession number: A8GJU8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: March 28, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health