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A8GJU8 (UPPP_SERP5) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:Spro_4294
OrganismSerratia proteamaculans (strain 568) [Complete proteome] [HAMAP]
Taxonomic identifier399741 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSerratia

Protein attributes

Sequence length274 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 274274Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000062811

Regions

Transmembrane6 – 2621Helical; Potential
Transmembrane45 – 6521Helical; Potential
Transmembrane94 – 11421Helical; Potential
Transmembrane117 – 13721Helical; Potential
Transmembrane155 – 17420Helical; Potential
Transmembrane191 – 21121Helical; Potential
Transmembrane223 – 24321Helical; Potential
Transmembrane253 – 27321Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A8GJU8 [UniParc].

Last modified November 13, 2007. Version 1.
Checksum: 041BA057C8D87605

FASTA27429,847
        10         20         30         40         50         60 
MADMHSLFIA FVLGVVEGLT EFLPVSSTGH MIIVGEWLGF TGDKAKTFEV IIQLGSILAV 

        70         80         90        100        110        120 
VVMFWRRLFG LIGIHFGGKP VEHEGKTTGH LKLGHILLAM IPAVVLGLLF HDVIKSLFAP 

       130        140        150        160        170        180 
KNVMYALVVG GFLLLAAEWL KPKKPSAEGL DDITYRQAFM IGCFQCLALW PGFSRSGSTI 

       190        200        210        220        230        240 
AGGMLVGVNR YAAAEFSFIL AVPMMIGASG LDLYKSLHFL TMGDLPMFAV GFATAFVVAL 

       250        260        270 
IAIKTFLTLI KRISFVPFAI YRFIVAGVVY MVFM 

« Hide

References

[1]"Complete sequence of chromosome of Serratia proteamaculans 568."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E. expand/collapse author list , Taghavi S., Newman L., Vangronsveld J., van der Lelie D., Richardson P.
Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 568.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000826 Genomic DNA. Translation: ABV43388.1.
RefSeqYP_001480516.1. NC_009832.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING399741.Spro_4294.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABV43388; ABV43388; Spro_4294.
GeneID5604464.
KEGGspe:Spro_4294.
PATRIC32421394. VBISerPro44537_4344.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAWRKISSS.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycSPRO399741:GI55-4379-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_SERP5
AccessionPrimary (citable) accession number: A8GJU8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families