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Protein

Membrane-bound lytic murein transglycosylase C

Gene

mltC

Organism
Serratia proteamaculans (strain 568)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division.UniRule annotation

Catalytic activityi

Exolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan, from either the reducing or the non-reducing ends of the peptidoglycan chains, with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processCell wall biogenesis/degradation

Protein family/group databases

CAZyiGH23 Glycoside Hydrolase Family 23

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-bound lytic murein transglycosylase CUniRule annotation (EC:4.2.2.n1UniRule annotation)
Alternative name(s):
Murein lyase CUniRule annotation
Gene namesi
Name:mltCUniRule annotation
Ordered Locus Names:Spro_4045
OrganismiSerratia proteamaculans (strain 568)
Taxonomic identifieri399741 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeSerratia
Proteomesi
  • UP000007074 Componenti: Chromosome

Subcellular locationi

  • Cell outer membrane UniRule annotation; Lipid-anchor UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16UniRule annotationAdd BLAST16
ChainiPRO_100006947917 – 358Membrane-bound lytic murein transglycosylase CAdd BLAST342

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi17N-palmitoyl cysteineUniRule annotation1
Lipidationi17S-diacylglycerol cysteineUniRule annotation1

Keywords - PTMi

Lipoprotein, Palmitate

Interactioni

Protein-protein interaction databases

STRINGi399741.Spro_4045

Structurei

3D structure databases

ProteinModelPortaliA8GJ50
SMRiA8GJ50
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the transglycosylase Slt family.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4106S48 Bacteria
COG0741 LUCA
HOGENOMiHOG000283572
KOiK08306
OMAiAIMQIES
OrthoDBiPOG091H06EG

Family and domain databases

HAMAPiMF_01616 MltC, 1 hit
InterProiView protein in InterPro
IPR023346 Lysozyme-like_dom_sf
IPR023664 Murein_transglycosylaseC
IPR024570 Murein_transglycosylaseC_N
IPR000189 Transglyc_AS
IPR008258 Transglycosylase_SLT_dom_1
PfamiView protein in Pfam
PF11873 DUF3393, 1 hit
PF01464 SLT, 1 hit
SUPFAMiSSF53955 SSF53955, 1 hit
PROSITEiView protein in PROSITE
PS51257 PROKAR_LIPOPROTEIN, 1 hit
PS00922 TRANSGLYCOSYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A8GJ50-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKILALLVI APLLISCSGK KNTEVNEALV KDTNGFEILM GQFAHNIENI
60 70 80 90 100
WGLNEVLIAG PKDYVKYTDQ YQTRSHINFD SGAITIETIA TTDPAAHLRQ
110 120 130 140 150
AIISTLLMGD DPGSIDLYSD VNDIQISKEP FLYGQVLDNK GAPIRWEWRA
160 170 180 190 200
AHFADYLVQT KLQKRTSGLH VIYSVTIQLV PNHLDKRAHK YLPMVRKASE
210 220 230 240 250
KYGVEESLIL AIMQTESSFN PYAVSGSDAL GLMQVVQHTA GKDVFQMRGK
260 270 280 290 300
WGKPSRSYLF DPENNIDTGT AYLAILQNNY LGGIQNPTSR RYAVITAYNG
310 320 330 340 350
GAGSVLRVFS SDRTRAVGII NGMQPGDVYQ TLTTKHPASE SRHYLVKVNN

AQKSYRRR
Length:358
Mass (Da):39,925
Last modified:November 13, 2007 - v1
Checksum:i810C0EC4D92B20F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000826 Genomic DNA Translation: ABV43140.1
RefSeqiWP_012146747.1, NC_009832.1

Genome annotation databases

EnsemblBacteriaiABV43140; ABV43140; Spro_4045
KEGGispe:Spro_4045

Similar proteinsi

Entry informationi

Entry nameiMLTC_SERP5
AccessioniPrimary (citable) accession number: A8GJ50
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: March 28, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health