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A8GIX7

- SPEB_SERP5

UniProt

A8GIX7 - SPEB_SERP5

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Protein

Agmatinase

Gene

speB

Organism
Serratia proteamaculans (strain 568)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of putrescine from agmatine.UniRule annotation

Catalytic activityi

Agmatine + H2O = putrescine + urea.UniRule annotation

Cofactori

Manganese.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi126 – 1261ManganeseUniRule annotation
Metal bindingi149 – 1491ManganeseUniRule annotation
Metal bindingi151 – 1511ManganeseUniRule annotation
Metal bindingi153 – 1531ManganeseUniRule annotation
Metal bindingi230 – 2301ManganeseUniRule annotation
Metal bindingi232 – 2321ManganeseUniRule annotation

GO - Molecular functioni

  1. agmatinase activity Source: UniProtKB-HAMAP
  2. manganese ion binding Source: InterPro

GO - Biological processi

  1. putrescine biosynthetic process from arginine Source: UniProtKB-UniPathway
  2. spermidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Polyamine biosynthesis, Putrescine biosynthesis, Spermidine biosynthesis

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciSPRO399741:GI55-4056-MONOMER.
UniPathwayiUPA00534; UER00287.

Names & Taxonomyi

Protein namesi
Recommended name:
AgmatinaseUniRule annotation (EC:3.5.3.11UniRule annotation)
Alternative name(s):
Agmatine ureohydrolaseUniRule annotation
Short name:
AUHUniRule annotation
Gene namesi
Name:speBUniRule annotation
Ordered Locus Names:Spro_3972
OrganismiSerratia proteamaculans (strain 568)
Taxonomic identifieri399741 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSerratia
ProteomesiUP000007074: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306AgmatinasePRO_1000068497Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi399741.Spro_3972.

Structurei

3D structure databases

ProteinModelPortaliA8GIX7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the arginase family. Agmatinase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0010.
HOGENOMiHOG000204320.
KOiK01480.
OMAiIDARTVH.
OrthoDBiEOG6R2GW5.

Family and domain databases

Gene3Di3.40.800.10. 1 hit.
HAMAPiMF_01418. SpeB.
InterProiIPR023694. Agmatinase.
IPR005925. Agmatinase-rel.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view]
PANTHERiPTHR11358. PTHR11358. 1 hit.
PfamiPF00491. Arginase. 1 hit.
[Graphical view]
PIRSFiPIRSF036979. Arginase. 1 hit.
TIGRFAMsiTIGR01230. agmatinase. 1 hit.
PROSITEiPS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8GIX7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTLGHKSDN SLVSNAFGFL RFPLNFMPYD SDAEWVITGI PFDMATSGRA
60 70 80 90 100
GGRHGPAAIR QVSTNLAWEG NRWPWNFDLR DRVNVVDCGD IVFNFGDAQS
110 120 130 140 150
MSDNLQAHAE KLLAAGKRML SFGGDHFVTL PLLRAHAKHF GKMALVHFDA
160 170 180 190 200
HTDTYANGSQ YDHGTMFFHA PNEGLIDPTH SVQIGIRTEY DHDNGFTVLD
210 220 230 240 250
AAQVNDRSAD DLLAQIKQIV GDMPVYLTFD IDCLDPAFAP GTGTPVIGGL
260 270 280 290 300
TSDRALKLVR GMQSLNIVGM DVVEVAPAYD QSEITALAAA TLGLEMLYLQ

AAKKTK
Length:306
Mass (Da):33,374
Last modified:November 13, 2007 - v1
Checksum:iC3E196DB927F79E9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000826 Genomic DNA. Translation: ABV43067.1.
RefSeqiWP_012146674.1. NC_009832.1.
YP_001480195.1. NC_009832.1.

Genome annotation databases

EnsemblBacteriaiABV43067; ABV43067; Spro_3972.
GeneIDi5603149.
KEGGispe:Spro_3972.
PATRICi32420765. VBISerPro44537_4030.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000826 Genomic DNA. Translation: ABV43067.1 .
RefSeqi WP_012146674.1. NC_009832.1.
YP_001480195.1. NC_009832.1.

3D structure databases

ProteinModelPortali A8GIX7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 399741.Spro_3972.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV43067 ; ABV43067 ; Spro_3972 .
GeneIDi 5603149.
KEGGi spe:Spro_3972.
PATRICi 32420765. VBISerPro44537_4030.

Phylogenomic databases

eggNOGi COG0010.
HOGENOMi HOG000204320.
KOi K01480.
OMAi IDARTVH.
OrthoDBi EOG6R2GW5.

Enzyme and pathway databases

UniPathwayi UPA00534 ; UER00287 .
BioCyci SPRO399741:GI55-4056-MONOMER.

Family and domain databases

Gene3Di 3.40.800.10. 1 hit.
HAMAPi MF_01418. SpeB.
InterProi IPR023694. Agmatinase.
IPR005925. Agmatinase-rel.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view ]
PANTHERi PTHR11358. PTHR11358. 1 hit.
Pfami PF00491. Arginase. 1 hit.
[Graphical view ]
PIRSFi PIRSF036979. Arginase. 1 hit.
TIGRFAMsi TIGR01230. agmatinase. 1 hit.
PROSITEi PS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 568.

Entry informationi

Entry nameiSPEB_SERP5
AccessioniPrimary (citable) accession number: A8GIX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: October 1, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3