Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable L-aspartate dehydrogenase

Gene

nadX

Organism
Serratia proteamaculans (strain 568)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.UniRule annotation

Miscellaneous

The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.UniRule annotation

Catalytic activityi

L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes iminoaspartate from L-aspartate (dehydrogenase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable L-aspartate dehydrogenase (nadX)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes iminoaspartate from L-aspartate (dehydrogenase route), the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei120NAD; via amide nitrogenUniRule annotation1
Binding sitei186NADUniRule annotation1
Active sitei216UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processPyridine nucleotide biosynthesis
LigandNAD, NADP

Enzyme and pathway databases

UniPathwayiUPA00253; UER00456

Names & Taxonomyi

Protein namesi
Recommended name:
Probable L-aspartate dehydrogenaseUniRule annotation (EC:1.4.1.21UniRule annotation)
Gene namesi
Name:nadXUniRule annotation
Ordered Locus Names:Spro_3958
OrganismiSerratia proteamaculans (strain 568)
Taxonomic identifieri399741 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeSerratia
Proteomesi
  • UP000007074 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000673131 – 264Probable L-aspartate dehydrogenaseAdd BLAST264

Interactioni

Protein-protein interaction databases

STRINGi399741.Spro_3958

Structurei

3D structure databases

ProteinModelPortaliA8GIW3
SMRiA8GIW3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L-aspartate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108Q27 Bacteria
COG1712 LUCA
HOGENOMiHOG000206326
KOiK06989
OMAiMIMSVGA
OrthoDBiPOG091H0M4V

Family and domain databases

HAMAPiMF_01265 NadX, 1 hit
InterProiView protein in InterPro
IPR005106 Asp/hSer_DH_NAD-bd
IPR002811 Asp_DH
IPR020626 Asp_DH_prok
IPR011182 L-Asp_DH
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF01958 DUF108, 1 hit
PF03447 NAD_binding_3, 1 hit
PIRSFiPIRSF005227 Asp_dh_NAD_syn, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit

Sequencei

Sequence statusi: Complete.

A8GIW3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKIMMIGYG AMAREVLSRL PDGVSVGWIL ARAAHHAAID SAFGGQVQAL
60 70 80 90 100
THPDQCTEQP DLVLECASQQ AVAEFGEAVV TRGWPLAVIS TGALADAALQ
110 120 130 140 150
QRLQQACRQH QGQLIVLSGA VAGMDGLASA REGGLDSVTY QACKSPASWR
160 170 180 190 200
GSMAEQLIDL DAVSEAQVFF EGSAREAARL FPANANVAAT IALNGLGMDA
210 220 230 240 250
TRVRLLVDPA TRRNTHRLQV CGNFGEFQIE LSGNPLASNP KTSTLAALSA
260
VQACRRLVDG GFIA
Length:264
Mass (Da):27,768
Last modified:November 13, 2007 - v1
Checksum:i2F4AEBCAAA6FB520
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000826 Genomic DNA Translation: ABV43053.1
RefSeqiWP_012146660.1, NC_009832.1

Genome annotation databases

EnsemblBacteriaiABV43053; ABV43053; Spro_3958
KEGGispe:Spro_3958

Similar proteinsi

Entry informationi

Entry nameiASPD_SERP5
AccessioniPrimary (citable) accession number: A8GIW3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: March 28, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health