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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Serratia proteamaculans (strain 568)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA), Probable phosphoglycerate mutase GpmB (gpmB), 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmI)
  4. Enolase (eno)
  5. Pyruvate kinase (Spro_2187), Pyruvate kinase (Spro_2770)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36SubstrateUniRule annotation1
Binding sitei113SubstrateUniRule annotation1
Binding sitei146SubstrateUniRule annotation1
Binding sitei197ATPUniRule annotation1
Binding sitei313ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi339 – 342ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesi
Name:pgkUniRule annotation
Ordered Locus Names:Spro_3945
OrganismiSerratia proteamaculans (strain 568)
Taxonomic identifieri399741 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeSerratia
Proteomesi
  • UP000007074 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000580531 – 386Phosphoglycerate kinaseAdd BLAST386

Proteomic databases

PRIDEiA8GIV0

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi399741.Spro_3945

Structurei

3D structure databases

ProteinModelPortaliA8GIV0
SMRiA8GIV0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 23Substrate bindingUniRule annotation3
Regioni59 – 62Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105BZA Bacteria
COG0126 LUCA
HOGENOMiHOG000227107
KOiK00927
OMAiDMIFDIG
OrthoDBiPOG091H00YN

Family and domain databases

Gene3Di3.40.50.1260, 3 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit
PROSITEiView protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

A8GIV0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVINMSDLD LAGKRVLIRS DLNVPVKDGK VTSDARIRAS LPTIEAALKQ
60 70 80 90 100
GARVMVTSHL GRPTEGEYNE EFSLLPVVNY LKEHLKNPVR LAKDYLEGVD
110 120 130 140 150
VAEGELVVLE NVRFNKGEKK DDETLSKKYA ALCDVYVMDA FGTAHRAQAS
160 170 180 190 200
THGVGKFAPV ACAGPLLSAE LEALGKALKS PARPMVAVVG GSKVSTKFDV
210 220 230 240 250
LNSLVKIADT VIVGGGIANT FVAIDNNVGK SLYEPDFVDA ARKLRDEFKI
260 270 280 290 300
PVPTDSRVGT EFSETAPATL KKVSEVNDDE EIMDFGDETA LAMAKLLKEA
310 320 330 340 350
KTILWNGPVG VFEFPNFRKG TEIVARAIAD SEAFSIAGGG DTLAAIDLFG
360 370 380
IEDKISYIST GGGAFLEFVE GKALPAVVML EERAKQ
Length:386
Mass (Da):41,393
Last modified:November 13, 2007 - v1
Checksum:iE302E96F76A206FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000826 Genomic DNA Translation: ABV43040.1
RefSeqiWP_012146647.1, NC_009832.1

Genome annotation databases

EnsemblBacteriaiABV43040; ABV43040; Spro_3945
KEGGispe:Spro_3945

Similar proteinsi

Entry informationi

Entry nameiPGK_SERP5
AccessioniPrimary (citable) accession number: A8GIV0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: March 28, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health