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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Serratia proteamaculans (strain 568)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandPyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:Spro_3914
OrganismiSerratia proteamaculans (strain 568)
Taxonomic identifieri399741 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeSerratia
Proteomesi
  • UP000007074 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000620771 – 959Glycine dehydrogenase (decarboxylating)Add BLAST959

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei708N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi399741.Spro_3914

Structurei

3D structure databases

ProteinModelPortaliA8GIR9
SMRiA8GIR9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CBI Bacteria
COG0403 LUCA
COG1003 LUCA
HOGENOMiHOG000239369
KOiK00281
OMAiQTMVCDL
OrthoDBiPOG091H03O6

Family and domain databases

CDDicd00613 GDC-P, 2 hits
Gene3Di3.40.640.10, 2 hits
3.90.1150.10, 1 hit
HAMAPiMF_00711 GcvP, 1 hit
InterProiView protein in InterPro
IPR003437 GcvP
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11773 PTHR11773, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 2 hits
SUPFAMiSSF53383 SSF53383, 3 hits
TIGRFAMsiTIGR00461 gcvP, 1 hit

Sequencei

Sequence statusi: Complete.

A8GIR9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQTLSQLEH SEAFIERHIG SSAQQQQQLL EAVGARSLNA LIQQIVPADI
60 70 80 90 100
QLPAPPPVGD AATEHQALAE LKAIASQNQR YKSYIGMGYS AVLTPPVILR
110 120 130 140 150
NMLENPGWYT AYTPYQPEVS QGRLEALLNF QTVTLDLTGL DLASASLLDE
160 170 180 190 200
ATAAAEAMAL AKRASKLKDA NRFFVADDVH PQTLDVVRTR AATFGFEVIV
210 220 230 240 250
DKAEKVLELQ GVFGVLLQQV GTTGELHDYS ALLAELKNRK IGTSVAADIM
260 270 280 290 300
ALVLLTAPGK QGADVVFGSA QRFGVPMGYG GPHAAFFACR DEFKRSMPGR
310 320 330 340 350
IIGVSRDAAG NTALRMAMQT REQHIRREKA NSNICTSQVL LANIASLYAV
360 370 380 390 400
YHGPQGLQRI AGRIHRLTDI LAAGLQQAGL QLRHKTWFDT LTVEVKDKAA
410 420 430 440 450
VLERALSFGI NLRTDIHGAV GITLDEATSR EDVQTLFALL AGDNHGLDID
460 470 480 490 500
ALDAAVSKNS QSIPAGMLRK DPILTHPVFN SYHSETEMMR YMHRLERKDL
510 520 530 540 550
ALNQAMIPLG SCTMKLNAAA EMIPITWPEF SELHPFCPPE QAAGYKQMIG
560 570 580 590 600
QLSQWLVQLT GYDAVCMQPN SGAQGEYAGL LAIRHYHESR NESGRHICLI
610 620 630 640 650
PSSAHGTNPA SAQMAGMSVV VVACDKNGNI DLHDLRVKAE QAGEELSCIM
660 670 680 690 700
VTYPSTHGVY EETIREVCQI VHQFGGQVYL DGANMNAQVG ITTPGYIGAD
710 720 730 740 750
VSHLNLHKTF CIPHGGGGPG MGPIGVKAHL APFVPGHSVV QIDGVLTQQG
760 770 780 790 800
AVSAAPFGSA SILPISWMYI RMMGAEGLKQ ASQVAILNAN YIATRLKDAY
810 820 830 840 850
PVLYTGRDHR VAHECILDIR PLKEETGISE MDIAKRLIDY GFHAPTMSFP
860 870 880 890 900
VAGTLMVEPT ESESKVELDR FIDAMLAIRS EIDRVAKGEW PLEDNPLVNA
910 920 930 940 950
PHIQAELVSD WQHAYSRELA VFPIAGVREN KYWPSVKRLD DVYGDRNLFC

SCVPMSEYE
Length:959
Mass (Da):104,560
Last modified:November 13, 2007 - v1
Checksum:iD7874766280630A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000826 Genomic DNA Translation: ABV43009.1
RefSeqiWP_012146616.1, NC_009832.1

Genome annotation databases

EnsemblBacteriaiABV43009; ABV43009; Spro_3914
KEGGispe:Spro_3914

Similar proteinsi

Entry informationi

Entry nameiGCSP_SERP5
AccessioniPrimary (citable) accession number: A8GIR9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: March 28, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health