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A8GIR9

- GCSP_SERP5

UniProt

A8GIR9 - GCSP_SERP5

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, Spro_3914
Organism
Serratia proteamaculans (strain 568)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciSPRO399741:GI55-3998-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:Spro_3914
OrganismiSerratia proteamaculans (strain 568)
Taxonomic identifieri399741 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSerratia
ProteomesiUP000007074: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 959959Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_1000062077Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei708 – 7081N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi399741.Spro_3914.

Structurei

3D structure databases

ProteinModelPortaliA8GIR9.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

A8GIR9-1 [UniParc]FASTAAdd to Basket

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MTQTLSQLEH SEAFIERHIG SSAQQQQQLL EAVGARSLNA LIQQIVPADI    50
QLPAPPPVGD AATEHQALAE LKAIASQNQR YKSYIGMGYS AVLTPPVILR 100
NMLENPGWYT AYTPYQPEVS QGRLEALLNF QTVTLDLTGL DLASASLLDE 150
ATAAAEAMAL AKRASKLKDA NRFFVADDVH PQTLDVVRTR AATFGFEVIV 200
DKAEKVLELQ GVFGVLLQQV GTTGELHDYS ALLAELKNRK IGTSVAADIM 250
ALVLLTAPGK QGADVVFGSA QRFGVPMGYG GPHAAFFACR DEFKRSMPGR 300
IIGVSRDAAG NTALRMAMQT REQHIRREKA NSNICTSQVL LANIASLYAV 350
YHGPQGLQRI AGRIHRLTDI LAAGLQQAGL QLRHKTWFDT LTVEVKDKAA 400
VLERALSFGI NLRTDIHGAV GITLDEATSR EDVQTLFALL AGDNHGLDID 450
ALDAAVSKNS QSIPAGMLRK DPILTHPVFN SYHSETEMMR YMHRLERKDL 500
ALNQAMIPLG SCTMKLNAAA EMIPITWPEF SELHPFCPPE QAAGYKQMIG 550
QLSQWLVQLT GYDAVCMQPN SGAQGEYAGL LAIRHYHESR NESGRHICLI 600
PSSAHGTNPA SAQMAGMSVV VVACDKNGNI DLHDLRVKAE QAGEELSCIM 650
VTYPSTHGVY EETIREVCQI VHQFGGQVYL DGANMNAQVG ITTPGYIGAD 700
VSHLNLHKTF CIPHGGGGPG MGPIGVKAHL APFVPGHSVV QIDGVLTQQG 750
AVSAAPFGSA SILPISWMYI RMMGAEGLKQ ASQVAILNAN YIATRLKDAY 800
PVLYTGRDHR VAHECILDIR PLKEETGISE MDIAKRLIDY GFHAPTMSFP 850
VAGTLMVEPT ESESKVELDR FIDAMLAIRS EIDRVAKGEW PLEDNPLVNA 900
PHIQAELVSD WQHAYSRELA VFPIAGVREN KYWPSVKRLD DVYGDRNLFC 950
SCVPMSEYE 959
Length:959
Mass (Da):104,560
Last modified:November 13, 2007 - v1
Checksum:iD7874766280630A9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000826 Genomic DNA. Translation: ABV43009.1.
RefSeqiYP_001480137.1. NC_009832.1.

Genome annotation databases

EnsemblBacteriaiABV43009; ABV43009; Spro_3914.
GeneIDi5604354.
KEGGispe:Spro_3914.
PATRICi32420646. VBISerPro44537_3971.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000826 Genomic DNA. Translation: ABV43009.1 .
RefSeqi YP_001480137.1. NC_009832.1.

3D structure databases

ProteinModelPortali A8GIR9.
ModBasei Search...

Protein-protein interaction databases

STRINGi 399741.Spro_3914.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV43009 ; ABV43009 ; Spro_3914 .
GeneIDi 5604354.
KEGGi spe:Spro_3914.
PATRICi 32420646. VBISerPro44537_3971.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci SPRO399741:GI55-3998-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 568.

Entry informationi

Entry nameiGCSP_SERP5
AccessioniPrimary (citable) accession number: A8GIR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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