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A8GIR9

- GCSP_SERP5

UniProt

A8GIR9 - GCSP_SERP5

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Serratia proteamaculans (strain 568)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciSPRO399741:GI55-3998-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:Spro_3914
    OrganismiSerratia proteamaculans (strain 568)
    Taxonomic identifieri399741 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSerratia
    ProteomesiUP000007074: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 959959Glycine dehydrogenase (decarboxylating)PRO_1000062077Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei708 – 7081N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi399741.Spro_3914.

    Structurei

    3D structure databases

    ProteinModelPortaliA8GIR9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A8GIR9-1 [UniParc]FASTAAdd to Basket

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    MTQTLSQLEH SEAFIERHIG SSAQQQQQLL EAVGARSLNA LIQQIVPADI    50
    QLPAPPPVGD AATEHQALAE LKAIASQNQR YKSYIGMGYS AVLTPPVILR 100
    NMLENPGWYT AYTPYQPEVS QGRLEALLNF QTVTLDLTGL DLASASLLDE 150
    ATAAAEAMAL AKRASKLKDA NRFFVADDVH PQTLDVVRTR AATFGFEVIV 200
    DKAEKVLELQ GVFGVLLQQV GTTGELHDYS ALLAELKNRK IGTSVAADIM 250
    ALVLLTAPGK QGADVVFGSA QRFGVPMGYG GPHAAFFACR DEFKRSMPGR 300
    IIGVSRDAAG NTALRMAMQT REQHIRREKA NSNICTSQVL LANIASLYAV 350
    YHGPQGLQRI AGRIHRLTDI LAAGLQQAGL QLRHKTWFDT LTVEVKDKAA 400
    VLERALSFGI NLRTDIHGAV GITLDEATSR EDVQTLFALL AGDNHGLDID 450
    ALDAAVSKNS QSIPAGMLRK DPILTHPVFN SYHSETEMMR YMHRLERKDL 500
    ALNQAMIPLG SCTMKLNAAA EMIPITWPEF SELHPFCPPE QAAGYKQMIG 550
    QLSQWLVQLT GYDAVCMQPN SGAQGEYAGL LAIRHYHESR NESGRHICLI 600
    PSSAHGTNPA SAQMAGMSVV VVACDKNGNI DLHDLRVKAE QAGEELSCIM 650
    VTYPSTHGVY EETIREVCQI VHQFGGQVYL DGANMNAQVG ITTPGYIGAD 700
    VSHLNLHKTF CIPHGGGGPG MGPIGVKAHL APFVPGHSVV QIDGVLTQQG 750
    AVSAAPFGSA SILPISWMYI RMMGAEGLKQ ASQVAILNAN YIATRLKDAY 800
    PVLYTGRDHR VAHECILDIR PLKEETGISE MDIAKRLIDY GFHAPTMSFP 850
    VAGTLMVEPT ESESKVELDR FIDAMLAIRS EIDRVAKGEW PLEDNPLVNA 900
    PHIQAELVSD WQHAYSRELA VFPIAGVREN KYWPSVKRLD DVYGDRNLFC 950
    SCVPMSEYE 959
    Length:959
    Mass (Da):104,560
    Last modified:November 13, 2007 - v1
    Checksum:iD7874766280630A9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000826 Genomic DNA. Translation: ABV43009.1.
    RefSeqiYP_001480137.1. NC_009832.1.

    Genome annotation databases

    EnsemblBacteriaiABV43009; ABV43009; Spro_3914.
    GeneIDi5604354.
    KEGGispe:Spro_3914.
    PATRICi32420646. VBISerPro44537_3971.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000826 Genomic DNA. Translation: ABV43009.1 .
    RefSeqi YP_001480137.1. NC_009832.1.

    3D structure databases

    ProteinModelPortali A8GIR9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 399741.Spro_3914.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV43009 ; ABV43009 ; Spro_3914 .
    GeneIDi 5604354.
    KEGGi spe:Spro_3914.
    PATRICi 32420646. VBISerPro44537_3971.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci SPRO399741:GI55-3998-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 568.

    Entry informationi

    Entry nameiGCSP_SERP5
    AccessioniPrimary (citable) accession number: A8GIR9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3