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A8GIR9 (GCSP_SERP5) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:Spro_3914
OrganismSerratia proteamaculans (strain 568) [Complete proteome] [HAMAP]
Taxonomic identifier399741 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSerratia

Protein attributes

Sequence length959 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 959959Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000062077

Amino acid modifications

Modified residue7081N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
A8GIR9 [UniParc].

Last modified November 13, 2007. Version 1.
Checksum: D7874766280630A9

FASTA959104,560
        10         20         30         40         50         60 
MTQTLSQLEH SEAFIERHIG SSAQQQQQLL EAVGARSLNA LIQQIVPADI QLPAPPPVGD 

        70         80         90        100        110        120 
AATEHQALAE LKAIASQNQR YKSYIGMGYS AVLTPPVILR NMLENPGWYT AYTPYQPEVS 

       130        140        150        160        170        180 
QGRLEALLNF QTVTLDLTGL DLASASLLDE ATAAAEAMAL AKRASKLKDA NRFFVADDVH 

       190        200        210        220        230        240 
PQTLDVVRTR AATFGFEVIV DKAEKVLELQ GVFGVLLQQV GTTGELHDYS ALLAELKNRK 

       250        260        270        280        290        300 
IGTSVAADIM ALVLLTAPGK QGADVVFGSA QRFGVPMGYG GPHAAFFACR DEFKRSMPGR 

       310        320        330        340        350        360 
IIGVSRDAAG NTALRMAMQT REQHIRREKA NSNICTSQVL LANIASLYAV YHGPQGLQRI 

       370        380        390        400        410        420 
AGRIHRLTDI LAAGLQQAGL QLRHKTWFDT LTVEVKDKAA VLERALSFGI NLRTDIHGAV 

       430        440        450        460        470        480 
GITLDEATSR EDVQTLFALL AGDNHGLDID ALDAAVSKNS QSIPAGMLRK DPILTHPVFN 

       490        500        510        520        530        540 
SYHSETEMMR YMHRLERKDL ALNQAMIPLG SCTMKLNAAA EMIPITWPEF SELHPFCPPE 

       550        560        570        580        590        600 
QAAGYKQMIG QLSQWLVQLT GYDAVCMQPN SGAQGEYAGL LAIRHYHESR NESGRHICLI 

       610        620        630        640        650        660 
PSSAHGTNPA SAQMAGMSVV VVACDKNGNI DLHDLRVKAE QAGEELSCIM VTYPSTHGVY 

       670        680        690        700        710        720 
EETIREVCQI VHQFGGQVYL DGANMNAQVG ITTPGYIGAD VSHLNLHKTF CIPHGGGGPG 

       730        740        750        760        770        780 
MGPIGVKAHL APFVPGHSVV QIDGVLTQQG AVSAAPFGSA SILPISWMYI RMMGAEGLKQ 

       790        800        810        820        830        840 
ASQVAILNAN YIATRLKDAY PVLYTGRDHR VAHECILDIR PLKEETGISE MDIAKRLIDY 

       850        860        870        880        890        900 
GFHAPTMSFP VAGTLMVEPT ESESKVELDR FIDAMLAIRS EIDRVAKGEW PLEDNPLVNA 

       910        920        930        940        950 
PHIQAELVSD WQHAYSRELA VFPIAGVREN KYWPSVKRLD DVYGDRNLFC SCVPMSEYE 

« Hide

References

[1]"Complete sequence of chromosome of Serratia proteamaculans 568."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E. expand/collapse author list , Taghavi S., Newman L., Vangronsveld J., van der Lelie D., Richardson P.
Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 568.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000826 Genomic DNA. Translation: ABV43009.1.
RefSeqYP_001480137.1. NC_009832.1.

3D structure databases

ProteinModelPortalA8GIR9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING399741.Spro_3914.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABV43009; ABV43009; Spro_3914.
GeneID5604354.
KEGGspe:Spro_3914.
PATRIC32420646. VBISerPro44537_3971.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAFDSRPYS.
OrthoDBEOG6HMXDX.

Enzyme and pathway databases

BioCycSPRO399741:GI55-3998-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_SERP5
AccessionPrimary (citable) accession number: A8GIR9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families