Skip Header

 
Contribute Send feedback

Reviewed, UniProtKB/Swiss-Prot A8GIL1 (LLDD_SERP5)

Last modified November 25, 2008. Version 9. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    L-lactate dehydrogenase [cytochrome]
    EC=1.1.2.3
Gene names
Name: lldD
Ordered Locus Names: Spro_3855
OrganismSerratia proteamaculans (strain 568) [Complete proteome] [HAMAP]
Taxonomic identifier399741 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Serratia

Hide | Top

Protein attributes

Sequence length380 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

Hide | Top

General annotation (Comments)

Catalytic activity

(S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c + 2 H(+).

Cofactor

FMN By similarity.

Sequence similarities

Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

Contains 1 FMN hydroxy acid dehydrogenase domain.

Hide | Top

Ontologies

Keywords

   LigandFMN
Flavoprotein
   Molecular functionOxidoreductase
   Technical termComplete proteome

Gene Ontology (GO)

   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionFMN binding

Inferred from electronic annotation. Source: InterPro

L-lactate dehydrogenase (cytochrome) activity

Inferred from electronic annotation. Source: HAMAP

electron carrier activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 380380L-lactate dehydrogenase [cytochrome]
PRO_1000068993

Regions

Domain1 – 380380FMN hydroxy acid dehydrogenase
Nucleotide binding306 – 33025FMN By similarity

Sites

Active site2751Proton acceptor By similarity
Binding site241Substrate Potential
Binding site1061FMN By similarity
Binding site1271FMN By similarity
Binding site1291Substrate By similarity
Binding site1551FMN By similarity
Binding site1641Substrate By similarity
Binding site2511FMN By similarity
Binding site2781Substrate Potential

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
A8GIL1-1 [UniParc].

Last modified November 13, 2007. Version 1.
Checksum: 790CD55D3D60DCA8

FASTA38040,877
        10         20         30         40         50         60 
MIISASTDYR AAAQAKLPPF LFHYIDGGAY AEHTLRRNTE DLAGIALRQR ILRNMSDLSL 

        70         80         90        100        110        120 
ETSLFGEKLA MPVILGPVGL TGMYARRGEV QAAKAAAQKG IPFTLSTVSV CPIEEVAPAI 

       130        140        150        160        170        180 
DRPMWFQLYV LKDRGFMRNA LERAKAAGVK TLVFTVDMPV PGARYRDAHS GMSGPNAAVR 

       190        200        210        220        230        240 
RMLQAVTHPQ WAWDVGLCGK PHDLGNVSAY RGKPTSLEDY IGWLGTNFDP SISWKDLDWI 

       250        260        270        280        290        300 
REFWQGPMII KGILDPEDAK DAVRFGADGI VVSNHGGRQL DGVLSTAHAL PAIAEAVKGD 

       310        320        330        340        350        360 
ITLLADSGIR SGLDVVRMIA LGADGVLLGR AFAYALAAAG QAGVANLLEL IDKEMRVAMT 

       370        380 
LIGAKTIADI SADSLVQGLR

« Hide

Hide | Top

References

[1]"Complete sequence of chromosome of Serratia proteamaculans 568."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E. expand/collapse author list , Taghavi S., Newman L., Vangronsveld J., van der Lelie D., Richardson P.
Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Hide | Top

Cross-references

Sequence databases

CP000826 Genomic DNA. Translation: ABV42951.1.
RefSeqYP_001480079.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID5606182.
GenomeReviewsGene locus Spro_3855 in contig CP000826_GR.
KEGGspe:Spro_3855.

Organism-specific databases

CMRSearch...

Family and domain databases

HAMAPMF_01559.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR012133. Alpha_OHA_DHase_FMN.
IPR008259. FMN_hydac_DHase_AS.
IPR000262. FMN_OHA_DHase.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PfamPF01070. FMN_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEPS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Hide | Top

Entry information

Entry nameLLDD_SERP5
AccessionPrimary (citable) accession number: A8GIL1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: November 25, 2008
This is version 9 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Hide | Top

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents