Reviewed, UniProtKB/Swiss-Prot A8GIG8 (ARGA_SERP5)

Names and origin

Protein names

Recommended name:
    Amino-acid acetyltransferase
    EC=2.3.1.1
Alternative name(s):
    N-acetylglutamate synthase
      Short name=AGS
      Short name=NAGS

Gene names

Name:	argA
Ordered Locus Names:	Spro_3812

Organism

Serratia proteamaculans (strain 568) [Complete proteome] [HAMAP]

Taxonomic identifier

399741 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Serratia

Protein attributes

Sequence length	441 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Acetyl-CoA + L-glutamate = CoA + N-acetyl-L-glutamate. HAMAP MF_01105
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4. HAMAP MF_01105
Subunit structure	Homohexamer By similarity. HAMAP MF_01105
Subcellular location	Cytoplasm By similarity HAMAP MF_01105.
Sequence similarities	Belongs to the acetyltransferase family. ArgA subfamily. Contains 1 N-acetyltransferase domain.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	acetyl-CoA:L-glutamate N-acetyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 441	441	Amino-acid acetyltransferase HAMAP MF_01105		PRO_1000084823
Regions
	Domain	295 – 434	140	N-acetyltransferase

Sequences

	Sequence		Length	Mass (Da)
	A8GIG8-1 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: 6C7F2135AEFBD1CF	FASTA	441	49,370
	10 20 30 40 50 60 MKERSTELVQ GFRHSVPYIN AHRGKTFVVM LGGEAIEHEN FANIVNDIGL LHSLGIRLVV 70 80 90 100 110 120 VYGARPQIDV NLAQHNLEPI YHKHTRVTDA HTLELVKQAA GLLQLDITAR LSMSLNNTPL 130 140 150 160 170 180 QGAHINVVSG NFIIAQPLGI DDGVDYCHSG RIRRIDEEAI HRQLDSNAIV LIGPVAVSVT 190 200 210 220 230 240 GESFNLTSEE VATQLAVKLK AEKMIGFCSS QGVTNQEGTI ISELFPNDAQ KRIEELEEHG 250 260 270 280 290 300 DYHSGTVRFL RGAVKACRSG VRRSHLISYQ EDGALVQELF SRDGIGTQIV MESAEQVRRA 310 320 330 340 350 360 TINDIGGILE LIRPLEQQGI LVRRSREQLE MEIDKFTIIE RDNLTIACAA LYPFPEEKIG 370 380 390 400 410 420 EMACVAVHPD YRSSSRGEML LQRVESQARQ MGLRKLFVLT TRSIHWFQER GFTPAEVDVL 430 440 PVEKQALYNY QRRSKILLAD L

References

[1]

"Complete sequence of chromosome of Serratia proteamaculans 568." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E. , Taghavi S., Newman L., Vangronsveld J., van der Lelie D., Richardson P. Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000826 Genomic DNA. Translation: ABV42908.1.
RefSeq	YP_001480036.1.
3D structure databases
SMR	A8GIG8. Positions 7-441.
ModBase	Search...
Protein-protein interaction databases
STRING	A8GIG8.
Genome annotation databases
GeneID	5606903.
GenomeReviews	Gene locus Spro_3812 in contig CP000826_GR.
KEGG	spe:Spro_3812.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0548.
HOGENOM	HBG545264.
OMA	APYIHAF.
Family and domain databases
HAMAP	MF_01105. N-acetyl_glu_synth. [Tree]
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR001048. Asp/Glu/Uridylate_kinase. IPR000182. GCN5-rel_AcTrfase. IPR010167. NH2A_AcTrfase_ArgA. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit. G3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 1 hit.
Pfam	PF00696. AA_kinase. 1 hit. PF00583. Acetyltransf_1. 1 hit. [Graphical view]
PIRSF	PIRSF000423. ArgA. 1 hit.
TIGRFAMs	TIGR01890. N-Ac-Glu-synth. 1 hit.
PROSITE	PS51186. GNAT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGA_SERP5

Accession

Primary (citable) accession number: A8GIG8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	November 13, 2007
Last modified:	February 9, 2010
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)