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A8GID3

- LPXB_SERP5

UniProt

A8GID3 - LPXB_SERP5

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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Serratia proteamaculans (strain 568)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciSPRO399741:GI55-3857-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:Spro_3777
OrganismiSerratia proteamaculans (strain 568)
Taxonomic identifieri399741 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSerratia
ProteomesiUP000007074: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 382382Lipid-A-disaccharide synthasePRO_1000060774Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi399741.Spro_3777.

Structurei

3D structure databases

ProteinModelPortaliA8GID3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

A8GID3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQNRPLTIGL VAGETSGDIL GAGLIRALKA QIPDARFVGV AGPLMQAEGC
60 70 80 90 100
ETWYEMEELA VMGVVEVLER LPRLLKIRKD LTRRFSDLAP DVFVGIDAPD
110 120 130 140 150
FNITLEGRLK QRGIRTIHYV SPSVWAWRQK RVFKIGKATD LVLAFLPFEK
160 170 180 190 200
AFYDRFNVPC RFIGHTMADA MPLQPDKLAA RAKLGIAADA RCLALLPGSR
210 220 230 240 250
GAEVEMLSAD FLKTAQLLRT RYPELELVVP LVNAKRREQF ERIKAEVAPE
260 270 280 290 300
LRVHLLNGQG REAMIASDAA LLASGTAALE CMLAKCPMVV GYRMKPFTFW
310 320 330 340 350
IAQRLVKTPY VSLPNLLAGR EIVTELLQHD CVPDKLAASV MPLLEDSPQT
360 370 380
DELKQTFLTL HQSIRCGADE QAAQAVLELA KA
Length:382
Mass (Da):42,312
Last modified:November 13, 2007 - v1
Checksum:i544FC0A596EBAC34
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000826 Genomic DNA. Translation: ABV42873.1.
RefSeqiWP_012146482.1. NC_009832.1.
YP_001480001.1. NC_009832.1.

Genome annotation databases

EnsemblBacteriaiABV42873; ABV42873; Spro_3777.
GeneIDi5607353.
KEGGispe:Spro_3777.
PATRICi32420370. VBISerPro44537_3837.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000826 Genomic DNA. Translation: ABV42873.1 .
RefSeqi WP_012146482.1. NC_009832.1.
YP_001480001.1. NC_009832.1.

3D structure databases

ProteinModelPortali A8GID3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 399741.Spro_3777.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV42873 ; ABV42873 ; Spro_3777 .
GeneIDi 5607353.
KEGGi spe:Spro_3777.
PATRICi 32420370. VBISerPro44537_3837.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci SPRO399741:GI55-3857-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 568.

Entry informationi

Entry nameiLPXB_SERP5
AccessioniPrimary (citable) accession number: A8GID3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: October 29, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3