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A8GID3

- LPXB_SERP5

UniProt

A8GID3 - LPXB_SERP5

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Protein
Lipid-A-disaccharide synthase
Gene
lpxB, Spro_3777
Organism
Serratia proteamaculans (strain 568)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciSPRO399741:GI55-3857-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:Spro_3777
OrganismiSerratia proteamaculans (strain 568)
Taxonomic identifieri399741 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSerratia
ProteomesiUP000007074: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 382382Lipid-A-disaccharide synthaseUniRule annotation
PRO_1000060774Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi399741.Spro_3777.

Structurei

3D structure databases

ProteinModelPortaliA8GID3.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

A8GID3-1 [UniParc]FASTAAdd to Basket

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MQNRPLTIGL VAGETSGDIL GAGLIRALKA QIPDARFVGV AGPLMQAEGC    50
ETWYEMEELA VMGVVEVLER LPRLLKIRKD LTRRFSDLAP DVFVGIDAPD 100
FNITLEGRLK QRGIRTIHYV SPSVWAWRQK RVFKIGKATD LVLAFLPFEK 150
AFYDRFNVPC RFIGHTMADA MPLQPDKLAA RAKLGIAADA RCLALLPGSR 200
GAEVEMLSAD FLKTAQLLRT RYPELELVVP LVNAKRREQF ERIKAEVAPE 250
LRVHLLNGQG REAMIASDAA LLASGTAALE CMLAKCPMVV GYRMKPFTFW 300
IAQRLVKTPY VSLPNLLAGR EIVTELLQHD CVPDKLAASV MPLLEDSPQT 350
DELKQTFLTL HQSIRCGADE QAAQAVLELA KA 382
Length:382
Mass (Da):42,312
Last modified:November 13, 2007 - v1
Checksum:i544FC0A596EBAC34
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000826 Genomic DNA. Translation: ABV42873.1.
RefSeqiYP_001480001.1. NC_009832.1.

Genome annotation databases

EnsemblBacteriaiABV42873; ABV42873; Spro_3777.
GeneIDi5607353.
KEGGispe:Spro_3777.
PATRICi32420370. VBISerPro44537_3837.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000826 Genomic DNA. Translation: ABV42873.1 .
RefSeqi YP_001480001.1. NC_009832.1.

3D structure databases

ProteinModelPortali A8GID3.
ModBasei Search...

Protein-protein interaction databases

STRINGi 399741.Spro_3777.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV42873 ; ABV42873 ; Spro_3777 .
GeneIDi 5607353.
KEGGi spe:Spro_3777.
PATRICi 32420370. VBISerPro44537_3837.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci SPRO399741:GI55-3857-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 568.

Entry informationi

Entry nameiLPXB_SERP5
AccessioniPrimary (citable) accession number: A8GID3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: May 14, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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