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Protein

NAD kinase

Gene

nadK

Organism
Serratia proteamaculans (strain 568)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei73Proton acceptorUniRule annotation1
Binding sitei158NADUniRule annotation1
Binding sitei175NADUniRule annotation1
Binding sitei177NADUniRule annotation1
Binding sitei247NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi73 – 74NADUniRule annotation2
Nucleotide bindingi147 – 148NADUniRule annotation2
Nucleotide bindingi188 – 193NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:Spro_3685
OrganismiSerratia proteamaculans (strain 568)
Taxonomic identifieri399741 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeSerratia
Proteomesi
  • UP000007074 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000795081 – 292NAD kinaseAdd BLAST292

Interactioni

Protein-protein interaction databases

STRINGi399741.Spro_3685

Structurei

3D structure databases

ProteinModelPortaliA8GI41
SMRiA8GI41
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91 Bacteria
COG0061 LUCA
HOGENOMiHOG000227221
KOiK00858
OMAiVNLGHVG
OrthoDBiPOG091H02D1

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

A8GI41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKKFACIGI VGHPRHPSAL ATHEMLFHWL VARGYSVMVE RQIAQDLGLK
60 70 80 90 100
DAVTGSLAEI GQKADLAVVV GGDGNMLGAA RVLARYDIKV IGVNRGNLGF
110 120 130 140 150
LTDLDPDNAL QQLADVLEGE YIDEQRFLLE TIVHKENQQC RISTAINEVV
160 170 180 190 200
LHPGKVAHMI EFEVYIDDRF AFSQRSDGLI IATPTGSTAY SLSAGGPILT
210 220 230 240 250
PSLEAIALVP MFPHTLSARP LVINGNSTIR LKFSQIGSDL EISCDSQIAL
260 270 280 290
PIQEGEEVLI RRSDFHLNLI HPKDYSYFNT LSTKLGWSKK LF
Length:292
Mass (Da):32,092
Last modified:November 13, 2007 - v1
Checksum:i97F1621AB3A055A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000826 Genomic DNA Translation: ABV42781.1
RefSeqiWP_012146391.1, NC_009832.1

Genome annotation databases

EnsemblBacteriaiABV42781; ABV42781; Spro_3685
KEGGispe:Spro_3685

Similar proteinsi

Entry informationi

Entry nameiNADK_SERP5
AccessioniPrimary (citable) accession number: A8GI41
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 13, 2007
Last modified: March 28, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health