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Protein

Probable lipid kinase YegS-like

Gene

Spro_3562

Organism
Serratia proteamaculans (strain 568)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Probably phosphorylates lipids; the in vivo substrate is unknown.UniRule annotation

Cofactori

Mg2+UniRule annotation, Ca2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit. Ca2+ may be able to substitute.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei40ATPUniRule annotation1
Binding sitei95ATPUniRule annotation1
Metal bindingi215Magnesium; via carbonyl oxygenUniRule annotation1
Metal bindingi218MagnesiumUniRule annotation1
Metal bindingi220Magnesium; via carbonyl oxygenUniRule annotation1
Active sitei271Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi66 – 72ATPUniRule annotation7

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPRO399741:GI55-3629-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable lipid kinase YegS-likeUniRule annotation (EC:2.7.1.-UniRule annotation)
Gene namesi
Ordered Locus Names:Spro_3562
OrganismiSerratia proteamaculans (strain 568)
Taxonomic identifieri399741 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeSerratia
Proteomesi
  • UP000007074 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000682551 – 305Probable lipid kinase YegS-likeAdd BLAST305

Interactioni

Protein-protein interaction databases

STRINGi399741.Spro_3562.

Structurei

3D structure databases

ProteinModelPortaliA8GHR8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 134DAGKcUniRule annotationAdd BLAST133

Sequence similaritiesi

Belongs to the diacylglycerol/lipid kinase family. YegS lipid kinase subfamily.UniRule annotation
Contains 1 DAGKc domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107TE5. Bacteria.
COG1597. LUCA.
HOGENOMiHOG000261396.
OMAiHWQGDLL.
OrthoDBiPOG091H02HT.

Family and domain databases

HAMAPiMF_01377. YegS. 1 hit.
InterProiIPR005218. Diacylglycerol/lipid_kinase.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR022433. Lip_kinase_YegS.
IPR016064. NAD/diacylglycerol_kinase.
[Graphical view]
PfamiPF00781. DAGK_cat. 1 hit.
[Graphical view]
SMARTiSM00046. DAGKc. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.
TIGRFAMsiTIGR03702. lip_kinase_YegS. 1 hit.
TIGR00147. TIGR00147. 1 hit.
PROSITEiPS50146. DAGK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8GHR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHPPAPALLI INGKGAGNEE VRLAVQKLRD ENQTLHVRVT WEQGDAARYV
60 70 80 90 100
QEACQLGVAT LIAGGGDGTI NEVAAALAAL PAKGRPVLGI LPLGTANDFA
110 120 130 140 150
MACNIPLIPE QALRLAVKGR AVPIDLAKVN DQRYFINMAT GGFGTRITTE
160 170 180 190 200
TPEKLKAALG GVSYFIHGLL RMDTLKADRC EIRGPDFHWS GDALVIGIGN
210 220 230 240 250
GKQAGGGQQL CPDALINDGL LQLRLLTADE LLPTLIASLF NDEENKNVIG
260 270 280 290 300
AALPWLEIDA PHEMTFNLDG EPLKGRHFRI EVLPNAIECR LPPNCELLGQ

TQSSQ
Length:305
Mass (Da):32,665
Last modified:November 13, 2007 - v1
Checksum:i4250019769755C68
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000826 Genomic DNA. Translation: ABV42658.1.
RefSeqiWP_012146271.1. NC_009832.1.

Genome annotation databases

EnsemblBacteriaiABV42658; ABV42658; Spro_3562.
KEGGispe:Spro_3562.
PATRICi32419928. VBISerPro44537_3621.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000826 Genomic DNA. Translation: ABV42658.1.
RefSeqiWP_012146271.1. NC_009832.1.

3D structure databases

ProteinModelPortaliA8GHR8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi399741.Spro_3562.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABV42658; ABV42658; Spro_3562.
KEGGispe:Spro_3562.
PATRICi32419928. VBISerPro44537_3621.

Phylogenomic databases

eggNOGiENOG4107TE5. Bacteria.
COG1597. LUCA.
HOGENOMiHOG000261396.
OMAiHWQGDLL.
OrthoDBiPOG091H02HT.

Enzyme and pathway databases

BioCyciSPRO399741:GI55-3629-MONOMER.

Family and domain databases

HAMAPiMF_01377. YegS. 1 hit.
InterProiIPR005218. Diacylglycerol/lipid_kinase.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR022433. Lip_kinase_YegS.
IPR016064. NAD/diacylglycerol_kinase.
[Graphical view]
PfamiPF00781. DAGK_cat. 1 hit.
[Graphical view]
SMARTiSM00046. DAGKc. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.
TIGRFAMsiTIGR03702. lip_kinase_YegS. 1 hit.
TIGR00147. TIGR00147. 1 hit.
PROSITEiPS50146. DAGK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYEGS_SERP5
AccessioniPrimary (citable) accession number: A8GHR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: November 2, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.