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Protein

Mannonate dehydratase

Gene

uxuA

Organism
Serratia proteamaculans (strain 568)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the dehydration of D-mannonate.UniRule annotation

Catalytic activityi

D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O.UniRule annotation

Cofactori

Fe2+UniRule annotation, Mn2+UniRule annotation

Pathwayi: pentose and glucuronate interconversion

This protein is involved in the pathway pentose and glucuronate interconversion, which is part of Carbohydrate metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway pentose and glucuronate interconversion and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
LigandIron, Manganese

Enzyme and pathway databases

UniPathwayiUPA00246

Names & Taxonomyi

Protein namesi
Recommended name:
Mannonate dehydrataseUniRule annotation (EC:4.2.1.8UniRule annotation)
Alternative name(s):
D-mannonate hydro-lyaseUniRule annotation
Gene namesi
Name:uxuAUniRule annotation
Ordered Locus Names:Spro_3238
OrganismiSerratia proteamaculans (strain 568)
Taxonomic identifieri399741 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeSerratia
Proteomesi
  • UP000007074 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000577031 – 396Mannonate dehydrataseAdd BLAST396

Interactioni

Protein-protein interaction databases

STRINGi399741.Spro_3238

Structurei

3D structure databases

ProteinModelPortaliA8GGU6
SMRiA8GGU6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mannonate dehydratase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CHZ Bacteria
COG1312 LUCA
HOGENOMiHOG000195381
KOiK01686
OMAiIPNGQVW
OrthoDBiPOG091H06VS

Family and domain databases

HAMAPiMF_00106 UxuA, 1 hit
InterProiView protein in InterPro
IPR004628 Man_deHydtase
IPR036237 Xyl_isomerase-like_sf
PANTHERiPTHR30387 PTHR30387, 1 hit
PfamiView protein in Pfam
PF03786 UxuA, 1 hit
PIRSFiPIRSF016049 Man_dehyd, 1 hit
SUPFAMiSSF51658 SSF51658, 1 hit
TIGRFAMsiTIGR00695 uxuA, 1 hit

Sequencei

Sequence statusi: Complete.

A8GGU6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQTWRWYGP NDPVSLDDVR QAGATGVVTA LHHIPNGEVW PIEEIKARQA
60 70 80 90 100
LLAEKGLVWS VVESIPVHEE IKTHSGNYQQ HIAHYQQSLR NLAACGIDTV
110 120 130 140 150
CYNFMPILDW TRTDLEYLLP DGSKALRFDQ IAFAAFDLHI LQRAGAEQDY
160 170 180 190 200
TQEEQQQAAA RFAAMSEADI AKLTGNIIAG LPGAEEGYTL DQFRARLAEY
210 220 230 240 250
DAIDKAQLRE NMAVFLRAIV PVAEEVGVRL AVHPDDPPRP LLGLPRIVST
260 270 280 290 300
IEDMQWFKQT VDSLHNGFTM CTGSYGVRED NDLVRMIETF GDRIHFTHLR
310 320 330 340 350
ATCREDNPKS FHEGAHLQGD VDMVAVIEAI LSEEQRRHQT GDTRPIPMRP
360 370 380 390
DHGHQMLDDL KKKTNPGYSA IGRLKGLAEL RGVELALKRR FFPELP
Length:396
Mass (Da):44,631
Last modified:November 13, 2007 - v1
Checksum:i5FC0502E5CB7D895
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000826 Genomic DNA Translation: ABV42336.1
RefSeqiWP_012145954.1, NC_009832.1

Genome annotation databases

EnsemblBacteriaiABV42336; ABV42336; Spro_3238
KEGGispe:Spro_3238

Similar proteinsi

Entry informationi

Entry nameiUXUA_SERP5
AccessioniPrimary (citable) accession number: A8GGU6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: March 28, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health