Reviewed, UniProtKB/Swiss-Prot A8GGU6 (UXUA_SERP5)

Names and origin

Protein names

Recommended name:
    Mannonate dehydratase
    EC=4.2.1.8
Alternative name(s):
    D-mannonate hydrolase

Gene names

Name:	uxuA
Ordered Locus Names:	Spro_3238

Organism

Serratia proteamaculans (strain 568) [Complete proteome] [HAMAP]

Taxonomic identifier

399741 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Serratia

Protein attributes

Sequence length	396 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O. HAMAP MF_00106
Pathway	Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP MF_00106
Sequence similarities	Belongs to the mannonate dehydratase family.

Ontologies

Keywords
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glucuronate catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	mannonate dehydratase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 396	396	Mannonate dehydratase HAMAP MF_00106		PRO_1000057703

Sequences

	Sequence		Length	Mass (Da)
	A8GGU6-1 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: 5FC0502E5CB7D895	FASTA	396	44,631
	10 20 30 40 50 60 MEQTWRWYGP NDPVSLDDVR QAGATGVVTA LHHIPNGEVW PIEEIKARQA LLAEKGLVWS 70 80 90 100 110 120 VVESIPVHEE IKTHSGNYQQ HIAHYQQSLR NLAACGIDTV CYNFMPILDW TRTDLEYLLP 130 140 150 160 170 180 DGSKALRFDQ IAFAAFDLHI LQRAGAEQDY TQEEQQQAAA RFAAMSEADI AKLTGNIIAG 190 200 210 220 230 240 LPGAEEGYTL DQFRARLAEY DAIDKAQLRE NMAVFLRAIV PVAEEVGVRL AVHPDDPPRP 250 260 270 280 290 300 LLGLPRIVST IEDMQWFKQT VDSLHNGFTM CTGSYGVRED NDLVRMIETF GDRIHFTHLR 310 320 330 340 350 360 ATCREDNPKS FHEGAHLQGD VDMVAVIEAI LSEEQRRHQT GDTRPIPMRP DHGHQMLDDL 370 380 390 KKKTNPGYSA IGRLKGLAEL RGVELALKRR FFPELP

References

[1]

"Complete sequence of chromosome of Serratia proteamaculans 568." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E. , Taghavi S., Newman L., Vangronsveld J., van der Lelie D., Richardson P. Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000826 Genomic DNA. Translation: ABV42336.1.
RefSeq	YP_001479464.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A8GGU6.
Genome annotation databases
GeneID	5606369.
GenomeReviews	Gene locus Spro_3238 in contig CP000826_GR.
KEGG	spe:Spro_3238.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	VHEEIKT.
Family and domain databases
HAMAP	MF_00106. [Tree]
InterPro	IPR004628. Man_deHydtase. IPR013022. Xyl_isomerase-like_TIM-brl. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
Pfam	PF03786. UxuA. 1 hit. [Graphical view]
PIRSF	PIRSF016049. Man_dehyd. 1 hit.
TIGRFAMs	TIGR00695. uxuA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UXUA_SERP5

Accession

Primary (citable) accession number: A8GGU6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	November 13, 2007
Last modified:	November 3, 2009
This is version 12 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)