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Protein

Catalase-peroxidase

Gene

katG

Organism
Serratia proteamaculans (strain 568)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei93Transition state stabilizerUniRule annotation1
Active sitei97Proton acceptorUniRule annotation1
Metal bindingi264Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandHeme, Iron, Metal-binding

Protein family/group databases

PeroxiBasei7335 SprCP01

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:Spro_3192
OrganismiSerratia proteamaculans (strain 568)
Taxonomic identifieri399741 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeSerratia
Proteomesi
  • UP000007074 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003549121 – 732Catalase-peroxidaseAdd BLAST732

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki96 ↔ 223Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-249)UniRule annotation
Cross-linki223 ↔ 249Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-96)UniRule annotation

Post-translational modificationi

Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiA8GGQ0

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi399741.Spro_3192

Structurei

3D structure databases

ProteinModelPortaliA8GGQ0
SMRiA8GGQ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X Bacteria
COG0376 LUCA
HOGENOMiHOG000218110
KOiK03782
OMAiPEEDIYW
OrthoDBiPOG091H05R1

Family and domain databases

HAMAPiMF_01961 Catal_peroxid, 1 hit
InterProiView protein in InterPro
IPR000763 Catalase_peroxidase
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR019794 Peroxidases_AS
IPR019793 Peroxidases_heam-ligand_BS
PANTHERiPTHR30555 PTHR30555, 1 hit
PfamiView protein in Pfam
PF00141 peroxidase, 2 hits
PRINTSiPR00460 BPEROXIDASE
PR00458 PEROXIDASE
SUPFAMiSSF48113 SSF48113, 2 hits
TIGRFAMsiTIGR00198 cat_per_HPI, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS00436 PEROXIDASE_2, 1 hit
PS50873 PEROXIDASE_4, 1 hit

Sequencei

Sequence statusi: Complete.

A8GGQ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTESKCPFS GGGKPNTPRR GPSNQDWWPN QLSLKPLHQH SSLSDPMDPD
60 70 80 90 100
FDYAKAFNSL DLAAVKQDLH ALMTDSQEWW PADFGHYGGL FIRMAWHSAG
110 120 130 140 150
TYRIGDGRGG AGEGQQRFAP LNSWPDNVSL DKARRLLWPI KQKYGRKISW
160 170 180 190 200
ADLIVLTGNV ALESMGFKTF GYAGGRADTW EPDDVYWGSE KIWLELSGGQ
210 220 230 240 250
NSRYSGDRDL EDPLAAVQMG LIYVNPEGPD GNPDPVAAAR DIRETFARMA
260 270 280 290 300
MNDEETVALI AGGHTFGKTH GAGPASHVGD DPETAGLERQ GLGWQSSFGT
310 320 330 340 350
GKGKDAITSG LEVTWTTTPT QWNHDFFKHL FEYEWELTQS PAGAHQWVAK
360 370 380 390 400
DVGETIPDAF DPAKKQRPTM LTTDLSLRFD PAYEKISRRF YEHPDQLADA
410 420 430 440 450
FSRAWYKLTH RDMGPRARYL GPEVPAEELI WQDPIPAVDH QLINDQDIAD
460 470 480 490 500
LKTSILTSGL PISVLVSTAW ASASTFRGSD KRGGANGARI RLAPQKDWAI
510 520 530 540 550
NQPAQLAQTL AKLEDIQQAF NNAQSGNKRV SLADLIVLAG AAAVEQAAAN
560 570 580 590 600
AGHPVSVPFT PGRMDATQEQ TDVDSFEAME PVADGFRNYL ERQFNIPAEA
610 620 630 640 650
LLVDKAQLLT LTAPEMTVLV GGLRVLNANV GQSQHGVLTQ RPQALSNDFF
660 670 680 690 700
VNLLDMGTTW KAAGEDGVFE GQDSQTGALK WTATRADLIF GSHSQLRALA
710 720 730
EVYGSSDAQA SFVYDFVAAW NKVMNLDRFD LA
Length:732
Mass (Da):80,366
Last modified:November 13, 2007 - v1
Checksum:iB426A424D961C8B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000826 Genomic DNA Translation: ABV42290.1
RefSeqiWP_012145908.1, NC_009832.1

Genome annotation databases

EnsemblBacteriaiABV42290; ABV42290; Spro_3192
KEGGispe:Spro_3192

Similar proteinsi

Entry informationi

Entry nameiKATG_SERP5
AccessioniPrimary (citable) accession number: A8GGQ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: November 13, 2007
Last modified: March 28, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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