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A8GGN3

- BGAL_SERP5

UniProt

A8GGN3 - BGAL_SERP5

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Protein

Beta-galactosidase

Gene
lacZ, Spro_3173
Organism
Serratia proteamaculans (strain 568)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.UniRule annotation

Cofactori

Binds 2 magnesium ions per monomer By similarity.UniRule annotation
Binds 1 sodium ion per monomer By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei104 – 1041Substrate By similarity
Metal bindingi203 – 2031Sodium By similarity
Binding sitei203 – 2031Substrate By similarity
Sitei357 – 3571Transition state stabilizer By similarity
Sitei391 – 3911Transition state stabilizer By similarity
Metal bindingi416 – 4161Magnesium 1 By similarity
Metal bindingi418 – 4181Magnesium 1 By similarity
Active sitei461 – 4611Proton donor By similarity
Metal bindingi461 – 4611Magnesium 1 By similarity
Binding sitei461 – 4611Substrate By similarity
Active sitei537 – 5371Nucleophile By similarity
Metal bindingi597 – 5971Magnesium 2 By similarity
Metal bindingi601 – 6011Sodium; via carbonyl oxygen By similarity
Metal bindingi604 – 6041Sodium By similarity
Binding sitei604 – 6041Substrate By similarity
Binding sitei1002 – 10021Substrate By similarity

GO - Molecular functioni

  1. beta-galactosidase activity Source: UniProtKB-EC
  2. carbohydrate binding Source: InterPro
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding, Sodium

Enzyme and pathway databases

BioCyciSPRO399741:GI55-3237-MONOMER.

Protein family/group databases

CAZyiGH2. Glycoside Hydrolase Family 2.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidase (EC:3.2.1.23)
Short name:
Beta-gal
Alternative name(s):
Lactase
Gene namesi
Name:lacZ
Ordered Locus Names:Spro_3173
OrganismiSerratia proteamaculans (strain 568)
Taxonomic identifieri399741 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSerratia
ProteomesiUP000007074: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. beta-galactosidase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10291029Beta-galactosidaseUniRule annotationPRO_0000367008Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi399741.Spro_3173.

Structurei

3D structure databases

ProteinModelPortaliA8GGN3.
SMRiA8GGN3. Positions 15-1021.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni537 – 5404Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3250.
HOGENOMiHOG000252443.
KOiK01190.
OMAiNPPFVPK.
OrthoDBiEOG6XWV0T.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
2.60.40.320. 2 hits.
2.70.98.10. 1 hit.
3.20.20.80. 1 hit.
HAMAPiMF_01687. Beta_gal.
InterProiIPR004199. B-gal_small/dom_5.
IPR011013. Gal_mutarotase_SF_dom.
IPR008979. Galactose-bd-like.
IPR014718. Glyco_hydro-type_carb-bd_sub.
IPR006101. Glyco_hydro_2.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR023232. Glyco_hydro_2_AS.
IPR023933. Glyco_hydro_2_beta_Galsidase.
IPR023230. Glyco_hydro_2_CS.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR006103. Glyco_hydro_2_TIM.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF02929. Bgal_small_N. 1 hit.
PF00703. Glyco_hydro_2. 1 hit.
PF02836. Glyco_hydro_2_C. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view]
PRINTSiPR00132. GLHYDRLASE2.
SMARTiSM01038. Bgal_small_N. 1 hit.
[Graphical view]
SUPFAMiSSF49303. SSF49303. 2 hits.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
SSF74650. SSF74650. 1 hit.
PROSITEiPS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8GGN3-1 [UniParc]FASTAAdd to Basket

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MSSLPYPSLK DLLARRDWQN PACTHYQRLA AHPPFSSWRN LNAARDDKSS     50
ESRQILNGDW QFSYFDKPQA VPDGWLQQDL TDADTLAVPS NWQLAAYDAP 100
IYTNVRYPIP VNPPQVPEEN PTGCYSRQFT VDPAWLAEGQ TRIIFDGVNS 150
AFYLWCNGHW VGYSQDSRLP AEFDLSPWLQ AGENRLAVMV LRWCDGSYLE 200
DQDMWRMSGI FRDVSLLHKP ATHLSDIRIT TPLYDSFRRG ELVAEVHINQ 250
PAQHRVQLQL WRDGQLVGEK TQAFGSEIID ERGAYEDRTT LCLPVEQPAL 300
WSAETPTLYR ATVTLLSPEG KIIEVEAYDV GFRQVEISNG LLKLNGQPLL 350
IRGTNRHEHH PQHGQVMDEA TMRHDILLMK QHNFNAVRCS HYPNHPLWYR 400
LCDRYGLYVV DEANIETHGM QPMNRLSDDP LWLPAMSERV TRMVQRDRNH 450
PCIIIWSLGN ESGHGCNHDA LYRWVKTQDP TRPVQYEGGG ANSAATDIIC 500
PMYARVDQDQ PFPAVPKWSI KKWIGLPDEH RPLILCEYAH AMGNSFGGFD 550
RYWQAFRQYP RLQGGFVWDW VDQALTRSDE NGNPYWAYGG DFGDTPNDRQ 600
FCLNGLVFPD RTPHPALFEA QRAQQFFQFT FDAETLTLTV NSEYLFRQTD 650
NERLNWRLEL DGTERASGSF DLNLLPQSSA SFPLLERLPM LHQPGELWLN 700
VEVVQPLATD WSEANHRCAW DQWLVPRTLH FAPPAVAGSA PQLSQNDQTI 750
DITHGHQRWQ FTRHDGCLSQ WWQHDHSQLL TPLRDNFIRA PLDNDIGISE 800
VERIDPNAWV ERWKLAGMYR LEERCTLLQA DQLSDGVRVV SEHLFEADGQ 850
TLLRSRKQWL FDSEGAVSIS VDVDIAASLP PPARIGLSCQ LKEIHPQAQW 900
LGLGPHENYP DRRLAAQFGR WQQPLEALHT PYIFPGENGL RCETRSLLYG 950
GWHIDGRFHF SLSRYGLRQL MECSHQHLLQ PEAGTWLSLD GFHMGVGGDD 1000
SWSPSVNQDY LLSGSHYHYQ LRLKRAERS 1029
Length:1,029
Mass (Da):118,303
Last modified:November 13, 2007 - v1
Checksum:i9FFADB850DE58679
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000826 Genomic DNA. Translation: ABV42273.1.
RefSeqiYP_001479401.1. NC_009832.1.

Genome annotation databases

EnsemblBacteriaiABV42273; ABV42273; Spro_3173.
GeneIDi5605502.
KEGGispe:Spro_3173.
PATRICi32419128. VBISerPro44537_3233.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000826 Genomic DNA. Translation: ABV42273.1 .
RefSeqi YP_001479401.1. NC_009832.1.

3D structure databases

ProteinModelPortali A8GGN3.
SMRi A8GGN3. Positions 15-1021.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 399741.Spro_3173.

Protein family/group databases

CAZyi GH2. Glycoside Hydrolase Family 2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV42273 ; ABV42273 ; Spro_3173 .
GeneIDi 5605502.
KEGGi spe:Spro_3173.
PATRICi 32419128. VBISerPro44537_3233.

Phylogenomic databases

eggNOGi COG3250.
HOGENOMi HOG000252443.
KOi K01190.
OMAi NPPFVPK.
OrthoDBi EOG6XWV0T.

Enzyme and pathway databases

BioCyci SPRO399741:GI55-3237-MONOMER.

Family and domain databases

Gene3Di 2.60.120.260. 1 hit.
2.60.40.320. 2 hits.
2.70.98.10. 1 hit.
3.20.20.80. 1 hit.
HAMAPi MF_01687. Beta_gal.
InterProi IPR004199. B-gal_small/dom_5.
IPR011013. Gal_mutarotase_SF_dom.
IPR008979. Galactose-bd-like.
IPR014718. Glyco_hydro-type_carb-bd_sub.
IPR006101. Glyco_hydro_2.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR023232. Glyco_hydro_2_AS.
IPR023933. Glyco_hydro_2_beta_Galsidase.
IPR023230. Glyco_hydro_2_CS.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR006103. Glyco_hydro_2_TIM.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF02929. Bgal_small_N. 1 hit.
PF00703. Glyco_hydro_2. 1 hit.
PF02836. Glyco_hydro_2_C. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view ]
PRINTSi PR00132. GLHYDRLASE2.
SMARTi SM01038. Bgal_small_N. 1 hit.
[Graphical view ]
SUPFAMi SSF49303. SSF49303. 2 hits.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
SSF74650. SSF74650. 1 hit.
PROSITEi PS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 568.

Entry informationi

Entry nameiBGAL_SERP5
AccessioniPrimary (citable) accession number: A8GGN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: November 13, 2007
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi