A8GG87 (A8GG87_SERP5) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Acetaldehyde dehydrogenase HAMAP MF_01657
EC=1.2.1.10 HAMAP MF_01657

Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] HAMAP MF_01657

Gene names

Name:	mhpF HAMAP MF_01657
Ordered Locus Names:	Spro_3026

Organism

Serratia proteamaculans (strain 568) [Complete proteome] [HAMAP] EMBL ABV42127.1

Taxonomic identifier

399741 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Serratia

Protein attributes

Sequence length	295 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP MF_01657
Catalytic activity	Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP MF_01657
Pathway	Aromatic compound metabolism; 3-phenylpropanoate degradation. HAMAP MF_01657
Subunit structure	Interacts with MhpE By similarity. HAMAP MF_01657
Sequence similarities	Belongs to the acetaldehyde dehydrogenase family. HAMAP MF_01657

Ontologies

Keywords
Biological process	Aromatic hydrocarbons catabolism HAMAP MF_01657
Ligand	NAD HAMAP MF_01657
Molecular function	Oxidoreductase HAMAP MF_01657
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic compound catabolic process Inferred from electronic annotation. Source: HAMAP cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	NAD binding Inferred from electronic annotation. Source: HAMAP acetaldehyde dehydrogenase (acetylating) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	10 – 13	4	NAD By similarity HAMAP MF_01657
Sites
	Binding site	265	1	NAD By similarity HAMAP MF_01657

Sequences

	Sequence		Length	Mass (Da)
	A8GG87 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: 1B17AD5EE0C06CA8	FASTA	295	31,074
	10 20 30 40 50 60 MTLSVAVIGT GAIGMDLVNK IYRSSWLHCG LVAGRNKDSA GLAIATELGC PISAGGIDAI 70 80 90 100 110 120 LAAPKPFDVV FDATNAMSHV KHWELLRPLG TLLIDLTPSH LGKMIVPTVT GTEALTDRNV 130 140 150 160 170 180 SLISCGGQAS IPILHALSRH FQINDIEVVA TVASNILGRA TRVNIDEYVE TTQIALSAFT 190 200 210 220 230 240 GVANTKAILN ISPATPPAMF RVTIFADIPG VTAEQITPVV TAAAAAVREF SAGYRLTALK 250 260 270 280 290 VTEGRASISL EVTASSKVMP EYAGNLDLIN SAAILVAEQY AHYRNKAEVA NDYSH

References

[1]

"Complete sequence of chromosome of Serratia proteamaculans 568." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E. , Taghavi S., Newman L., Vangronsveld J., van der Lelie D., Richardson P. Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 568.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000826 Genomic DNA. Translation: ABV42127.1.
RefSeq	YP_001479255.1. NC_009832.1.
3D structure databases
ProteinModelPortal	A8GG87.
ModBase	Search...
Protein-protein interaction databases
STRING	A8GG87.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5604074.
GenomeReviews	Gene locus Spro_3026 in contig CP000826_GR.
KEGG	spe:Spro_3026.
PATRIC	32418830. VBISerPro44537_3087.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG4569.
HOGENOM	HBG300125.
OMA	PEFANIR.
ProtClustDB	PRK08300.
Enzyme and pathway databases
BioCyc	SPRO399741:SPRO_3026-MONOMER.
Family and domain databases
HAMAP	MF_01657. Ac_ald_DH_ac. [Tree]
InterPro	IPR003361. Acetaldehyde_dehydrogenase. IPR015426. Acetylaldehyde_DH_C. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K04073.
PANTHER	PTHR21123. Acetylald_dh. 1 hit.
Pfam	PF09290. AcetDehyd-dimer. 1 hit. PF01118. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR03215. Ac_ald_DH_ac. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A8GG87_SERP5

Accession

Primary (citable) accession number: A8GG87

Entry history

Integrated into UniProtKB/TrEMBL:	November 13, 2007
Last sequence update:	November 13, 2007
Last modified:	December 14, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)